Extract of white sweet potato tuber against TNF-α-induced insulin resistance by activating the PI3K/Akt pathway in C2C12 myotubes

Shyur, Lie‐Fen; Varga, Viola; Chen, Chiao Ming; Mu, Shu Chi; Chang, Yevvon Yi-Chi; Li, Sing Chung

doi:10.1186/s40529-021-00315-8

Cited by 8 publications

(7 citation statements)

References 43 publications

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“…So, the study on IR has a great clinical significance in medical interventions. Basically, insulin exerts its effect through phosphorylation of phosphoinositide 3-kinase (PI3K) and protein kinase B (PkB, Akt) [72,73]. Next, through PI3k phosphorylation, it activates glucose transporter 4 (GLUT4).…”

Section: Diabetes Mellitus and Insulin Resistancementioning

confidence: 99%

Medicinal Components in Edible Mushrooms on Diabetes Mellitus Treatment

Das

Chen

et al. 2022

Pharmaceutics

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Mushrooms belong to the family “Fungi” and became famous for their medicinal properties and easy accessibility all over the world. Because of its pharmaceutical properties, including anti-diabetic, anti-inflammatory, anti-cancer, and antioxidant properties, it became a hot topic among scientists. However, depending on species and varieties, most of the medicinal properties became indistinct. With this interest, an attempt has been made to scrutinize the role of edible mushrooms (EM) in diabetes mellitus treatment. A systematic contemporary literature review has been carried out from all records such as Science Direct, PubMed, Embase, and Google Scholar with an aim to represents the work has performed on mushrooms focuses on diabetes, insulin resistance (IR), and preventive mechanism of IR, using different kinds of mushroom extracts. The final review represents that EM plays an important role in anticipation of insulin resistance with the help of active compounds, i.e., polysaccharide, vitamin D, and signifies α-glucosidase or α-amylase preventive activities. Although most of the mechanism is not clear yet, many varieties of mushrooms’ medicinal properties have not been studied properly. So, in the future, further investigation is needed on edible medicinal mushrooms to overcome the research gap to use its clinical potential to prevent non-communicable diseases.

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Section: Diabetes Mellitus and Insulin Resistancementioning

confidence: 99%

Medicinal Components in Edible Mushrooms on Diabetes Mellitus Treatment

Das

Chen

et al. 2022

Pharmaceutics

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“…In this respect, our work demonstrated that CP, beyond the anti-inflammatory action, was also able to upmodulate the GLUT-4 mRNA expression level. It is amply accepted that increased GLUT-4 levels are directly correlated to an improved glucose uptake [ 62 , 63 ] and to an ameliorative/regulatory effect on glucidic metabolism via the Akt signalling pathway [ 64 ], which in turn stimulates GLUT-4 translocation on the plasmatic membrane [ 65 , 66 ].…”

Section: Discussionmentioning

confidence: 99%

Convolvulus pluricaulis Choisy’s Extraction, Chemical Characterization and Evaluation of the Potential Effects on Glycaemic Balance in a 3T3-L1 Adipocyte Cell Model

et al. 2023

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Convolvulus pluricaulis (CP) is a common Indian herb, largely employed in Ayurvedic medicine and known for its neuroprotective and neuroinflammatory action. Its effectiveness against several pathologic/sub-pathologic conditions is widely accepted, but it is not yet completely chemically characterized. In recent years, several researchers have pointed out the involvement of CP and other Convolvulaceae in lipidic and glucidic metabolism, particularly in the control of hyperlipidaemia and diabetic conditions. In this scenario, the aim of the study was to chemically characterize the medium polarity part of the CP whole plant and its fractions and to shed light on their biological activity in adipocyte differentiation using the 3T3-L1 cell model. Our results demonstrated that the CP extract and fractions could upregulate the adipocyte differentiation through the modulation of the nuclear receptor PPARγ (Peroxisome Proliferator-Activated Receptor γ), broadly recognized as a key regulator of adipocyte differentiation, and the glucose transporter GLUT-4, which is fundamental for cellular glucose uptake and for metabolism control. CP also showed the ability to exert an anti-inflammatory effect, downregulating cytokines such as Rantes, MCP-1, KC, eotaxin, and GM-CSF, which are deeply involved in insulin resistance and glucose intolerance. Taken together, these data suggest that CP could exert a potential beneficial effect on glycemia and could be employed as an anti-diabetic adjuvant or, in any case, a means to better control glucose homeostasis.

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“…Some foods may also enhance insulin sensitivity through the Plin5-related pathway. For example, sweet potato squash improves insulin sensitivity through PPAR- γ and GLUT4 that activates 3T3-L1 adipocyte IRS-1/PI3K/AKT pathway [ 251 ]. Promoting insulin secretion and increasing insulin sensitivity is a relatively ideal treatment direction for insulin resistance/deficiency lipid metabolism abnormalities, which can effectively accelerate the utilization or storage of FAs to reduce lipid toxicity.…”

Section: Clinical Interventionmentioning

confidence: 99%

Plin5, a New Target in Diabetic Cardiomyopathy

Cui

Wang

Zhang

et al. 2022

Oxidative Medicine and Cellular Longevity

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Abnormal lipid accumulation is commonly observed in diabetic cardiomyopathy (DC), which can create a lipotoxic microenvironment and damage cardiomyocytes. Lipid toxicity is an important pathogenic factor due to abnormal lipid accumulation in DC. As a lipid droplet (LD) decomposition barrier, Plin5 can protect LDs from lipase decomposition and regulate lipid metabolism, which is involved in the occurrence and development of cardiovascular diseases. In recent years, studies have shown that Plin5 expression is involved in the pathogenesis of DC lipid toxicity, such as oxidative stress, mitochondrial dysfunction, endoplasmic reticulum (ER) stress, and insulin resistance (IR) and has become a key target of DC research. Therefore, understanding the relationship between Plin5 and DC progression as well as the mechanism of this process is crucial for developing new therapeutic approaches and exploring new therapeutic targets. This review is aimed at exploring the latest findings and roles of Plin5 in lipid metabolism and DC-related pathogenesis, to explore possible clinical intervention approaches.

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Extract of white sweet potato tuber against TNF-α-induced insulin resistance by activating the PI3K/Akt pathway in C2C12 myotubes

Cited by 8 publications

References 43 publications

Medicinal Components in Edible Mushrooms on Diabetes Mellitus Treatment

Medicinal Components in Edible Mushrooms on Diabetes Mellitus Treatment

Convolvulus pluricaulis Choisy’s Extraction, Chemical Characterization and Evaluation of the Potential Effects on Glycaemic Balance in a 3T3-L1 Adipocyte Cell Model

Plin5, a New Target in Diabetic Cardiomyopathy

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