Extracted polysaccharide from Nyctanthes arbor-tristis leaves: Chemical and antitussive properties

Ghosh, Kanika; Nosálóvá, G; Ray, Sayani; Sivová, Veronika; Nosál, S; Ray, Bimalendu

doi:10.1016/j.ijbiomac.2015.01.021

Cited by 4 publications

(2 citation statements)

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“…officinale is made up mostly of glucan. Compairing the acivity of uronic acid containing polysaccharides from medicinal plants such as Adhatoda vasica (WE), Nyctanthes arbor‐tristis (CP), Withania somnifera (F 3 ) (Chattopadhyay et al ., ; Ghosh et al ., ; Sinha et al ., ) and Z . Officinale (WEP) with codeine phosphate (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Notably, the water extracted fraction of Z. officinale is made up mostly of glucan. Compairing the acivity of uronic acid containing polysaccharides from medicinal plants such as Adhatoda vasica (WE), Nyctanthes arbor-tristis (CP), Withania somnifera (F 3 ) (Chattopadhyay et al, 2011;Ghosh et al, 2015;Sinha et al, 2011) and Z. Officinale (WEP) with codeine phosphate ( Fig. 4-C), and considering that glucan is the predominant constituent of WEP, one can presume that the glucan also has antitussive activity.…”

Section: Discussionmentioning

confidence: 99%

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Structural Elements and Cough Suppressing Activity of Polysaccharides from Zingiber officinale Rhizome

et al. 2015

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Zingiber officinale is used for the management of fever, bronchial asthma and cough for thousands of years. While the link to a particular indication has been established in human, the active principle of the formulation remains unknown. Herein, we have investigated a water extracted polysaccharides (WEP) containing fraction from its rhizome. Utilizing a traditional aqueous extraction protocol and using chemical, chromatographic and spectroscopic methods a fraction containing a branched glucan and polygalaturonan in a ratio of 59:1 was characterized. This glucan, which has a molecular mass of 36 kDa, is made up of terminal-, (1,4)- and (1,4,6)-linked α-Glcp residues. Oral administration of WEP in doses of 25 and 50 mg/kg body weight significantly inhibited the number of citric acid-induced cough efforts in guinea pigs. It does not alter the specific airway smooth muscle reactivity significantly. Thus, traditional aqueous extraction method provides molecular entities, which induces antitussive activity without addiction.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%