Extracting Deep Phenotypes for Chronic Kidney Disease Using Electronic Health Records

Abstract

Introduction:As chronic kidney disease (CKD) is among the most prevalent chronic diseases in the world with various rate of progression among patients, identifying its phenotypic subtypes is important for improving risk stratification and providing more targeted therapy and specific treatments for patients having different trajectories of the disease progression. Problem Definition and Data:The rapid growth and adoption of electronic health records (EHR) technology has created a unique opportunity to leverage the abundant clinical data, available as EHRs, to find meaningful phenotypic subtypes for CKD. In this study, we focus on extracting disease severity profiles for CKD while accounting for other confounding factors. Probabilistic Subtyping Model:We employ a probabilistic model to identify precise phenotypes from EHR data of patients who have chronic kidney disease. Using this model, patient's eGFR trajectory is decomposed as a combination of four different components including disease subtype effect, covariate effect, individual long-term effect and individual short-term effect.Experimental Results: The discovered disease subtypes obtained by Probabilistic Subtyping Model for CKD are presented and their clinical relevance is analyzed.Discussion: Several clinical health markers that were found associated with disease subtypes are presented with suggestion for further investigation on their use as risk predictors. Several assumptions in the study are also clarified and discussed.

Sustainable Development Goals relevant to kidney health: an update on progress

“…Encompassing both, the SDGs can promote kidney health in the population and thereby improve the chances of sustainable access to adequate care for those who develop kidney disease. records that report estimated glomerular filtration rate (eGFR) have enhanced awareness of CKD and AKI, facilitated new patient surveillance efforts and reduced the number of adverse events caused by inappropriate drug dosing or the use nephrotoxic medications 30,[37][38][39][40] . Such innovations can be rapidly implemented in HICs but the risk from nephrotoxic preparations is highest in LICs and middle-income countries (MICs) 41 , where it mostly affects young, otherwise healthy individuals 42 .…”