Extracting rose essential oil from rose slag with ionic liquid

Guo, Changchang; Zhang, Juan; Liu, Chaozheng; Bian, Yuhang; Shan, Qingwen

doi:10.1007/s13399-020-00751-9

Cited by 9 publications

(2 citation statements)

References 24 publications

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“…RO can also be produced through the photo oxygenation of citronellol ( Alsters et al., 2010 ; Xiao et al., 2017 ). Due to its commercial application, many studies report the use of rose oxide in the production of aromas and reactions of drug production ( Cavazzana et al., 2018 ; Gevorgyan et al., 2020 ; Guo et al., 2020 ; Xiao et al., 2017 ). Besides having a delicate, sweet and mild aroma, the rose essential oil has been described as a compound that has anti-inflammatory, calming, relaxing and antioxidant effects ( Guo et al., 2020 ; Nonato et al., 2012 ).…”

Section: Introductionmentioning

confidence: 99%

“…Due to its commercial application, many studies report the use of rose oxide in the production of aromas and reactions of drug production ( Cavazzana et al., 2018 ; Gevorgyan et al., 2020 ; Guo et al., 2020 ; Xiao et al., 2017 ). Besides having a delicate, sweet and mild aroma, the rose essential oil has been described as a compound that has anti-inflammatory, calming, relaxing and antioxidant effects ( Guo et al., 2020 ; Nonato et al., 2012 ). The anti-inflammatory activity of rose oxide was associated with its ability to inhibit IL-1β production ( Nonato et al., 2012 ).…”

Section: Introductionmentioning

confidence: 99%

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Antidepressant activity of rose oxide essential oil: possible involvement of serotonergic transmission

Maia

Andrade

Filgueiras

et al. 2021

Heliyon

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Rose oxide (RO) is a monoterpene found in rose oil fragrances. This monoterpene has been reported to possess anti-inflammatory activity, however, little is known regarding its pharmacological activity. The present study was carried out to evaluate its antidepressant action and possible mechanisms of action. Analysis of ADMET pharmacokinetic properties (absorption, distribution, metabolism, excretion and toxicity) of rose oxide was performed by computational prediction analysis. Behavioral tests were performed to assess the interaction between rose oxide and the central nervous system and antidepressant effect that includes: forced swim test (FST), tail suspension test (TST), open field test (OFT) and rota-rod test. The results of pharmacokinetic and toxicological properties indicate that rose oxide could be used orally, since it has good intestinal absorption as well as pharmacological and toxicological properties that can be similar to pharmacological compounds (regular hepatic metabolism and low toxicity). Treatment with 50 mg/kg of rose oxide was able to decrease the immobility time of animals not affected by FST and TST and was not able to alter the motor activity of the OFT and rota-rod test, suggesting modulation and antidepressant activity. Docking data suggest that rose oxide can bind to receptors in the serotonergic pathway. The results described here suggest that rose oxide has antidepressant activity, modulating the serotonergic pathway.

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