Extracting the Benefit of Nexrutine® for Cancer Prevention

Hussain, Suleman S.; Patel, Darpan I.; Ghosh, Rita; Kumar, Addanki P.

doi:10.1007/s40495-015-0029-7

Cited by 14 publications

(12 citation statements)

References 72 publications

(100 reference statements)

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“…The main chemical components of PAC are: alkaloids, limonin, flavones, terpenes, sterols, phenolic acid, and others, such as berberine, tetrahydroberberine, phellodendrine, magnoflorine, jatrorrhizine, palmatine, obacunone, limonin, obacunonic, hyperin, phellozid, β-sitosterol, and dictamnoilde17181920. Recent research shows that, PAC has a therapeutic effect in prostate cancer, but the previous research focused on the chemical composition analysis and pharmacodynamicals, this work addresses the active components and action mechanism of PAC against prostate cancer212223242526.…”

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confidence: 99%

Screening the active compounds of Phellodendri Amurensis cortex for treating prostate cancer by high-throughput chinmedomics

Zhang

Wang

et al. 2017

Sci Rep

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Screening the active compounds of herbal medicines is of importance to modern drug discovery. In this work, an integrative strategy was established to discover the effective compounds and their therapeutic targets using Phellodendri Amurensis cortex (PAC) aimed at inhibiting prostate cancer as a case study. We found that PAC could be inhibited the growth of xenograft tumours of prostate cancer. Global constituents and serum metabolites were analysed by UPLC-MS based on the established chinmedomics analysis method, a total of 54 peaks in the spectrum of PAC were characterised in vitro and 38 peaks were characterised in vivo. Among the 38 compounds characterised in vivo, 29 prototype components were absorbed in serum and nine metabolites were identified in vivo. Thirty-four metabolic biomarkers were related to prostate cancer, and PAC could observably reverse these metabolic biomarkers to their normal level and regulate the disturbed metabolic profile to a healthy state. A chinmedomics approach showed that ten absorbed constituents, as effective compounds, were associated with the therapeutic effect of PAC. In combination with bioactivity assays, the action targets were also predicted and discovered. As an illustrative case study, the strategy was successfully applied to high-throughput screening of active compounds from herbal medicine.

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confidence: 99%

Screening the active compounds of Phellodendri Amurensis cortex for treating prostate cancer by high-throughput chinmedomics

Zhang

Wang

et al. 2017

Sci Rep

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“…PLT is also used in combination preparations such as hepasor or nexrutine. Hepasor is an extract of the bark of Enantia chlorantha , which contains approximately 65% PLT and is used mainly in viral hepatitis, whereas nexrutine is an extract from Phellodendron amurense used in joint pain (Hussain, Pate, Ghosh, & Kumar, ; Olivier, Van Vuuren, & Moteetee, ).…”

Section: Pharmacology Of Pltmentioning

confidence: 99%

Palmatine: A review of pharmacological properties and pharmacokinetics

Tarabasz¹,

Kukuła-Koch

2019

Phytotherapy Research

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The aim of this review is to collect together the results of the numerous studies over the last two decades on the pharmacological properties of palmatine published in scientific databases like Scopus and PubMed, which are scattered across different publications. Palmatine, an isoquinoline alkaloid from the class of protoberberines, is a yellow compound present in the extracts from different representatives of Berberidaceae, Papaveraceae, Ranunculaceae, and Menispermaceae. It has been extensively used in traditional medicine of Asia in the treatment of jaundice, liver‐related diseases, hypertension, inflammation, and dysentery. New findings describe its possible applications in the treatment of civilization diseases like central nervous system‐related problems. This review intends to let this alkaloid come out from the shade of a more frequently described alkaloid: berberine. The toxicity, pharmacokinetics, and biological activities of this protoberberine alkaloid will be developed in this work.

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“…This is the first report regarding the safety and tolerability of Nx in PCA patients. However, the limitations of this study were the lack of a placebo-controlled arm, small cohort of patients, and use of single dose of Nx for short period of time [125,126]. …”

Section: Natural Products As Adjuvants In Cancer Therapymentioning

confidence: 99%

Food-based natural products for cancer management: Is the whole greater than the sum of the parts?

Hussain

Kumar

Ghosh

2016

Seminars in Cancer Biology

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The rise in cancer incidence and mortality in developing countries together with the human and financial cost of current cancer therapy mandates a closer look at alternative ways to overcome this burgeoning global healthcare problem. Epidemiological evidence for the association between cancer and diet and the long latency of most cancer progression have led to active exploration of whole and isolated natural chemicals from different naturally occurring substances in various preclinical and clinical settings. In general the lack of systemic toxicities of most ‘whole’ and ‘isolated’ natural compounds, their potential to reduce toxic doses and potential to delay the development of drug-resistance makes them promising candidates for cancer management. This review article examines the suggested molecular mechanisms affected by these substances focusing to a large extent on prostate cancer and deliberates on the disparate results obtained from cell culture, preclinical and clinical studies in an effort to highlight the use of whole extracts and isolated constituents for intervention. As such these studies underscore the importance of factors such as treatment duration, bioavailability, route of administration, selection criteria, standardized formulation and clinical end points in clinical trial design with both entities. Overall lack of parallel comparison studies between the whole natural products and their isolated compounds limits decisive conclusions regarding the superior utility of one over the other. We suggest the critical need for rigorous comparative research to identify which one of the two or both entities from nature would be best qualified to take on the mantle of cancer management.

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Extracting the Benefit of Nexrutine® for Cancer Prevention

Cited by 14 publications

References 72 publications

Screening the active compounds of Phellodendri Amurensis cortex for treating prostate cancer by high-throughput chinmedomics

Screening the active compounds of Phellodendri Amurensis cortex for treating prostate cancer by high-throughput chinmedomics

Palmatine: A review of pharmacological properties and pharmacokinetics

Food-based natural products for cancer management: Is the whole greater than the sum of the parts?

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