Extraction and Analysis of Polyphenolic Compounds in Ficus carica L.

Moyo, Babra; Tavengwa, Nikita Tawanda

doi:10.1007/978-3-031-16493-4_28

Cited by 2 publications

(3 citation statements)

References 90 publications

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“…It was observed that 90 s of irradiation time in this study was better for obtaining a good yield of TPC. These results were in agreement with other studies in which increasing extraction time also increased the yield of TPC(Moyo & Tavengwa, 2023;Tomasi et al, 2023).…”

supporting

confidence: 93%

RSM assisted phytochemical profiling of Vitex negundo and molecular docking studies of biological active compounds with target proteins

Sharma,

Gaur,

Singh

et al. 2024

Preprint

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Vitex negundo(Family-Verbenaceae) is a remarkable medicinal plant with numerous therapeutic applications. In this study, phytochemical screening was performed in Vitex negundoleaf extract, and extraction optimization was performed by applying response surface methodology (RSM). Methanolic extract and microwave-assisted extraction (MAE) were found to be appropriate for obtaining the maximum yield of bioactive compounds. In single-factor analysis, solvent concentration, microwave power, and time of extraction variations were analyzed to calculate the amount of TPC, TFC, and TAC in the extract. The quantity of TPC, TFC, and TAC were fairly obtained from 60%–95% (v/v) methanol concentration, 540 -900 W microwave power, and 60–90 s extraction time. Furthermore, we also employed the response surface methodology (RSM) for optimizing microwave-assisted extraction of Vitex negundo leaves by considering three key parameters: solvent concentration, extraction temperature, and extraction duration. Condition optimization for the extraction were obtained at 95% (v/v) methanol, 720W, and 90s with TPC (227.6 mg gallic acid equivalent (GAE)/g sample), TFC (978.2 mg RE/g sample), and TAC (82.13 mg ascorbic acid equivalents/g sample). The characterization of methanol extract of Vitex negundowas done by FTIR and GC–MS to identify the various active groups and types of bioactive constituent’s presence in the extract. Subsequently, the compounds were evaluated for their bioactivity through molecular docking interactions with target proteins in silico. Furthermore, the antibacterial activity of the optimized extract was studied against two Gram +ve (Bacillus sphaericus, Pectobacterium) and two Gram-ve (Escherichia coli, Pseudomonas aeruginosa) bacteria, and the inhibitory effect was observed in all four tested bacteria. The highest antibacterial activity was shown against B. sphaericus (19± 0.087) and E. coli (19±0.064) followed by Pectobacterium (18±0.068) and Pseudomonas(13±0.093). The hemolytic activity of the optimized leaf extract (at a dose of 20µg/ml) shows a minimum hemolytic activity, i.e., 1.33± 0.06 %. It may be concluded from the study that Vitex negundo is potential and safe source of natural antioxidants that can be utilized in green therapeutics.

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supporting

confidence: 93%

RSM assisted phytochemical profiling of Vitex negundo and molecular docking studies of biological active compounds with target proteins

Sharma,

Gaur,

Singh

et al. 2024

Preprint

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“…Additionally, employing microwave‐assisted extraction with low eutectic solvents in the extraction of fig leaves has resulted in higher contents of polyphenols and furanocoumarins (Wang et al, 2017). In general, microwave‐assisted extraction is a promising extraction method of phenolic compounds in FC, but the application is still very limited (Moyo & Tavengwa, 2023). It should also be noted that microwave‐assisted extraction is also technically challenging and requires good control of microwave power, extraction time and other parameters in the extraction process of phenolic compounds.…”

Section: Extraction Of Phenolic Compounds From Fcmentioning

confidence: 99%

“…Numerous studies have demonstrated the health benefits of phenolic compounds in FC, such as anti‐oxidant, anti‐inflammatory, anti‐obesity, anti‐diabetic, anti‐inflammatory, anti‐cancer and anti‐Alzheimer's (Aicha & Menadi, 2023; Kiralan et al, 2023; Moyo & Tavengwa, 2023). For example, quercetin in FC is a powerful natural anti‐oxidant and anti‐inflammatory (Lesjak et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

An updated review of composition, health benefits, and applications of phenolic compounds in Ficus Carica L.

Zhang,

Peng,

et al. 2024

eFood

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Ficus carica L. (FC) is rich in phenolic compounds such as phenolic acids, flavonoids, and anthocyanins. Phenolic compounds in FC show remarkable health benefits and applications. The composition of phenolic compounds in FC can vary with some factors, such as variety, ripeness, geographical location, extraction methods and processing methods. New techniques such as supercritical fluid extraction, subcritical water extraction and ionic liquid extraction should be further developed and combined with traditional techniques to obtain higher quality sources of phenolic compounds. Numerous in vivo and in vitro studies reported healthy benefits of phenolic compounds in FC, such as anti‐oxidant, anti‐inflammatory, anti‐diabetic, anti‐obesity, anti‐cancer and anti‐Alzheimer's. Further works are required to reveal mechanisms and structure‐activity relationships, such as targeted metabolomics and pharmacological studies. In terms of applications, phenolic compounds in FC as prebiotics on the intestinal flora need to be further studied to expand their applicability in food fermentation. In a word, this review highlights the remarkable health benefits and application value of phenolic compounds in FC.

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Extraction and Analysis of Polyphenolic Compounds in Ficus carica L.

Cited by 2 publications

References 90 publications

RSM assisted phytochemical profiling of Vitex negundo and molecular docking studies of biological active compounds with target proteins

RSM assisted phytochemical profiling of Vitex negundo and molecular docking studies of biological active compounds with target proteins

An updated review of composition, health benefits, and applications of phenolic compounds in Ficus Carica L.

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