The particle size of γ-alumina is prohibitively small, to such an extent that it has long presented a challenge to experimental characterization. The material is apparently not susceptible to Ostwald ripening, the reasons for which have been arcane. Herein, it is proposed that the material's particle size may be constrained due to the energetic preference of hydrogen defects to be positioned at the surface rather than within the interior. This preference, combined with the larger ratio of surface area to volume possessed by smaller particles, results in the tiny crystal characteristic of γ-alumina. Computational modeling, enabled by a recent method of computing accurate surface energies for asymmetric slab models, is employed to investigate this hypothesis and suggests an explanation for the dearth of large single crystals of γ-alumina.