Extraction and characterization of Hybiscus Rosa-Sinensis leaves mucilage for Pharmaceutical applications

Prabakaran, L; Murthy, V. M. R.; Karpakavalli, M.

doi:10.5530/rjps.2011.3.10

Cited by 4 publications

(3 citation statements)

References 8 publications

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“…About 1% of mucilage along with 5% of cold diluted trichloroacetic acid solution was homogenized, centrifuged, and neutralized by using sodium hydroxide and then dialyzed for 30 hrs against distilled water. The mucilage was reprecipitated using ethanol (three volumes) and washed successively with ethanol, acetone, and diethyl ether [16, 17]. The dried powder mucilage was characterized for physicochemical properties shown in Table 1.…”

Section: Methodsmentioning

confidence: 99%

Combined Effect of Synthetic and Natural Polymers in Preparation of Cetirizine Hydrochloride Oral Disintegrating Tablets: Optimization by Central Composite Design

Patro¹,

Sahu²

2017

Journal of Pharmaceutics

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Our aim was to employ experimental design to formulate and optimize cetirizine hydrochloride oral disintegrating tablets (ODTs) by direct compression technique, using the mutual effect of synthetic croscarmellose sodium (CCS) and natural Hibiscus rosa-sinensis mucilage (HRM) as disintegrants in the formulation. Central composite design (CCD) was applied to optimize the influence of three levels each of CCS (X 1) and HRM (X 2) concentrations (independent variables) for investigated responses: disintegration time (DT) (Y 1), % friability (F) (Y 2), and % cumulative drug release (DR) (Y 3) (dependent variables). This face-centered second-order model's reliability was verified by the probability and adequate precision values from the analysis of variance, while the significant factor effects influencing the studied responses were identified using multiple linear regression analysis. Perturbation and response surface plots were interpreted to evaluate the responses' sensitivity towards the variables. During optimization, the concentrations of the processed factors were evaluated, and the resulting values were in good agreement with predicted estimates endorsing the validity. Spectral study by Fourier Transform Infrared Spectroscopy (FTIR) and thermograms from Differential Scanning Calorimetry (DSC) demonstrated the drug-excipients compatibility of the optimized formulation. The optimized formulation has concentrations of 9.05 mg and 16.04 mg of CCS and HRM each, respectively, and the model predicted DT of 13.271 sec, F of 0.498, and DR of 99.768%.

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Section: Methodsmentioning

confidence: 99%

Combined Effect of Synthetic and Natural Polymers in Preparation of Cetirizine Hydrochloride Oral Disintegrating Tablets: Optimization by Central Composite Design

Patro¹,

Sahu²

2017

Journal of Pharmaceutics

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“…Method of extraction was adapted from Lai and Liang (2011) and Prabakran et al (2011), it was done by soaking the blended leaves of rose cactus in different solutions, distilled water or 0.14 M sodium hydroxide (w/v) 1:3 for 3 hours then heated up to 50°C, 70°C or 90°C by using water bath (Techne 12/TE-10 D, UK) and subsequently filtered. The filtrate was precipitated with acetone (1:3 v/v), then dried in an oven at 40°C and grinded before storing at 4°C.…”

Section: Mucilage Extractionmentioning

confidence: 99%

“…Determination of pH was done by using a pH meter (inoLab pH 730, Germany) at 1.0% w/v as described by Prabakran et al (2011). For mineral analysis, dried mucilage (1 g) was mixed with 8 ml of concentrated nitric acid and 1 ml of hydrogen peroxide and digested in Microwave Digester (Milestone ETHOS 1600 Microwave Digestion Labstation, UK) for 1 hour.…”

Section: Chemical Analysesmentioning

confidence: 99%

EXTRACTION AND CHARACTERIZATION OF MUCILAGE FROM LEAVES OF Pereskia bleo (ROSE CACTUS)

Hong

Ibrahim

2012

jtip

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Pereskia bleo (rose cactus) is a type of tropical herbs which has long been used for its medicinal benefits among Malays and is also known to contain complex polysaccharide called mucilage. In this study, mucilage from leaves of rose cactus was extracted by using distilled water or 0.14 M sodium hydroxide (NaOH) solution at three different temperatures (i.e. 50°C, 70°C or 90°C). There was a significant (p<0.05) interaction effect between type of medium used and temperature on yield of mucilage. Extraction using 0.14 M NaOH solution at 70°C provided the highest yield (2.55%) of mucilage as compared to other extraction conditions. The mucilage extracted with 0.14 M NaOH solution at 70°C was further characterized in terms of physicochemical properties and compared with arabic gum. The crude protein, moisture and ash content of the mucilage were 4.81%, 13.59% and 28.67% respectively. It possessed appreciable amount of elements such as calcium (48.96 mg/g sample), and potassium (15.58 mg/g sample). The pH value of the mucilage was 10.89 (alkaline) and it exhibited a clear thixotropic flow behavior with acceptable emulsion capacity (7.08%) and stability (7.31%) at 1% concentration. The colour of the mucilage and water holding capacity (WHC) was L*= 68.81, and 461.87 % respectively. These findings suggest that rose cactus mucilage could be an interesting functional food ingredient as it originated from a well-known medicinal plant though further study should be done in order to fully understand its potential as one of alternative food hydrocolloids. Keywords

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Hibiscus Rosa-Sinesis Leaves Polysaccharide as Solubility Enhancing Agent for Poorly Soluble Drug

Lakshmanan¹

2015

PPIJ

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The main purpose of this research was to use hydrophilic Hibiscus Rosa-sinesis (HRS) dry leaves mucilage as functionality solubility enhancing agent for the design and development of solid dispersion of the drug Telmisartan (TS) to formulate tablets and to study its in vitro quality control tests. The mucilage was extracted, isolated, purified and prepared solid dispersions with different ratio of drug: mucilage (1:0.5, 1:1.0, 1:1.5, 1:2.0 and 1:2.5) using solvent evaporation method and another. Two formulations were prepared using drug: mucilage ratio of 1:1.0 as co-grinding method (GM) and physical mixture (PM). The solubility study showed a significant enhancement in the aqueous solubility of the drug where the solubility rate was increased with the increment in ratio of the mucilage. The formulation giving the best solubility enhancement of Telmisartan in aqueous media was in the order of SD>GM>PM>API. Then, the dispersions were compressed into tablets where it passed the pre-compression and post-compression evaluation parameters. Swelling index increased as the amount of mucilage added to each formulation (SD1 to SD3). Nevertheless as the amount of mucilage is increased for formulation SD4 and SD5 (1:2.0 and 1:2.5 ratio of drug: mucilage) the swelling index were decreased. The in-vitro dissolution study revealed that there is marked decrease in the dissolution rate of Telmisartan for all the solid dispersion containing tablets when compared to Telmisartan API tablets. This proves with the increase in mucilage ratio, the drug release from the solid dispersion tablet got retarded because of the formation of highly viscous barrier layer at the interface of the tablet and dissolution medium. In conclusion, the solubility of the drug has been greatly enhanced by the solid dispersion technique incorporating HRS mucilage using solvent evaporation method. Therefore, it is suggested that the drug Telmisartan can be converted to solid dispersion using Hibiscus Rosa-sinesis dry leaves mucilage as solubility enhancing agent and the solid dispersion granules can be filled in capsules as a dosage form.

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Extraction and characterization of Hybiscus Rosa-Sinensis leaves mucilage for Pharmaceutical applications

Cited by 4 publications

References 8 publications

Combined Effect of Synthetic and Natural Polymers in Preparation of Cetirizine Hydrochloride Oral Disintegrating Tablets: Optimization by Central Composite Design

Combined Effect of Synthetic and Natural Polymers in Preparation of Cetirizine Hydrochloride Oral Disintegrating Tablets: Optimization by Central Composite Design

EXTRACTION AND CHARACTERIZATION OF MUCILAGE FROM LEAVES OF Pereskia bleo (ROSE CACTUS)

Hibiscus Rosa-Sinesis Leaves Polysaccharide as Solubility Enhancing Agent for Poorly Soluble Drug

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