Extraction and Characterization of Refined K-carrageenan of Red Algae [Kappaphycus Alvarezii (Doty ex P.C. Silva, 1996)] Originated from Karimun Jawa Islands

Manuhara, Godras Jati; Praseptiangga, Danar; Riyanto, Rachmad Adi

doi:10.1016/j.aqpro.2016.07.014

Cited by 64 publications

(29 citation statements)

References 8 publications

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“…Nevertheless, the anti-obesity mechanism of Kappaphycus alvarezii is still not well defined. The sulfated polysaccharide κ-carrageenan is a major component of Kappaphycus alvarezii , accounting for over one-third of its weight [7,11,12], and is considered a dietary fiber. There are numerous studies that describe the nutraceutical and pharmacological potentials of various marine polysaccharides [13,14,15,16,17,18], including carrageenan [19,20,21,22].…”

Section: Introductionmentioning

confidence: 99%

A Pilot Study on Anti-Obesity Mechanisms of Kappaphycus Alvarezii: The Role of Native κ-Carrageenan and the Leftover Sans-Carrageenan Fraction

Chin¹,

Mi²,

Cao³

et al. 2019

Nutrients

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Kappaphycus is a commercially important edible red alga widely cultivated for carrageenan production. Here, we aimed to investigate the anti-obesity mechanism of Kappaphycus alvarezii by comparing the effects of whole seaweed (T), extracted native κ-carrageenan (CGN), and the leftover fraction sans-carrageenan (SCGN) supplementations (5%, w/w) on diet-induced obese C57BL/6J mice. A high-fat diet induced both a raised body fat percentage and serum cholesterol level, increased adipocytes size, abnormal levels of adipocytokines, and promoted gut dysbiosis. Our results showed that, overall, both CGN and SCGN were more effective in reversing obesity and related metabolic syndromes to normal levels than T. Furthermore, these findings suggested that CGN- and SCGN-modulated gut dysbiosis induced by a high-fat diet, which may play an influencing role in adiponectin dysregulation. Our data also showed some evidence that CGN and SCGN have distinct effects on selected genes involved in lipid metabolism. In conclusion, both κ-carrageenan and SCGN have novel anti-obesity potential with possible different mechanisms of action.

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Section: Introductionmentioning

confidence: 99%

A Pilot Study on Anti-Obesity Mechanisms of Kappaphycus Alvarezii: The Role of Native κ-Carrageenan and the Leftover Sans-Carrageenan Fraction

Chin¹,

Mi²,

Cao³

et al. 2019

Nutrients

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“…Manuhara et al [21] studied Κ-carrageenan (RC) extracted from red algae originated from Karimun Jawa Island. They indicated that higher KCl concentration in extraction resulted in the increase of the carrageenan yield.…”

Section: Extraction Resultsmentioning

confidence: 99%

Locally Carrageenan Tested for Its Food Grade by Food and Agriculture Organization Method

Indriyati

Iskandar

Burhanuddin

et al. 2017

Asian J Pharm Clin Res

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Objective: This study aims to determine whether seagrass lalamakan (Dictyota dichotoma), ades (Gelidium sp.), agar (Gracilaria sp.), and saribuhu (Sargassum sp.) obtained from the Sindangkerta beach, Tasikmalaya, can produce carrageenan food grade according to the Food and Agriculture Organization (FAO), Food Chemical Codex (FCC), and European Economic Community (EEC).Methods: Seaweed was extracted with distilled water and 0.1N KOH at high temperature (90°C). The extract was tested for its characteristics such as solubility test, test sulfate, gel formation, and its infrared (IR) spectrum. Results:The yield obtained from solvent extraction with distilled water ranged from 21% to 27%, whereas for 0.1N KOH solvent between 10% and 11% by weight. The results of the study indicated that the fiber obtained from both extractions was carrageenan, as shown by the results of the solubility test, the formation of gel and the infrared spectrum showed a sulfate ester, 3,6-anhydrogalactose, galactose-4-sulfate, and 3,6-anhydrogalactose-2-sulfate which was characteristic of carrageenan. IR spectrum confirmed the availability of carrageenan. Results of the sulfate test content in all sample fibers using either distilled water or 0.1N KOH were below 15.0%. Conclusion:These results indicated that the generated carrageenan did not meet food grade standards set by the FAO, FCC, and EEC which was 15-40%. However, in fact, the carrageenan from the Sindangkerta beach has been produced and marketed in the local market.

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“…Carrageenans are anionic polysaccharides with D-galactoses (β (1-4)) as main constituents, and have a molecular weight ranging from (0.1–1) × 10 6 Da ( Figure 18 ). In this case, they can be obtained from the extracellular matrix of red seaweed (that is why was included as EPS here), such as Kappaphycus alvarezii [ 23 ]. These polymers have anionic charge due to the existence of sulphate groups.…”

Section: Exopolysaccharides For Producing Ddssmentioning

confidence: 99%

“…The last steps are polymer centrifugation and purification. A similar process has been followed to produce EPSs, such as alginate [ 15 ], dextran [ 16 ], xanthan gum [ 17 ], gellan gum [ 18 ], curdlan [ 19 ], levan [ 20 ], hyaluronic acid [ 21 ], pullulan [ 22 ], carrageenan [ 23 ], etc.…”

Section: Introductionmentioning

confidence: 99%

Microbial Exopolysaccharides as Drug Carriers

Cardea

2020

Polymers

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Microbial exopolysaccharides are peculiar polymers that are produced by living organisms and protect them against environmental factors. These polymers are industrially recovered from the medium culture after performing a fermentative process. These materials are biocompatible and biodegradable, possessing specific and beneficial properties for biomedical drug delivery systems. They can have antitumor activity, they can produce hydrogels with different characteristics due to their molecular structure and functional groups, and they can even produce nanoparticles via a self-assembly phenomenon. This review studies the potential use of exopolysaccharides as carriers for drug delivery systems, covering their versatility and their vast possibilities to produce particles, fibers, scaffolds, hydrogels, and aerogels with different strategies and methodologies. Moreover, the main properties of exopolysaccharides are explained, providing information to achieve an adequate carrier selection depending on the final application.

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Extraction and Characterization of Refined K-carrageenan of Red Algae [Kappaphycus Alvarezii (Doty ex P.C. Silva, 1996)] Originated from Karimun Jawa Islands

Cited by 64 publications

References 8 publications

A Pilot Study on Anti-Obesity Mechanisms of Kappaphycus Alvarezii: The Role of Native κ-Carrageenan and the Leftover Sans-Carrageenan Fraction

A Pilot Study on Anti-Obesity Mechanisms of Kappaphycus Alvarezii: The Role of Native κ-Carrageenan and the Leftover Sans-Carrageenan Fraction

Locally Carrageenan Tested for Its Food Grade by Food and Agriculture Organization Method

Microbial Exopolysaccharides as Drug Carriers

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