Extraction and determination of flubendiamide insecticide in food samples: A review

Aghris, S.; Alaoui, Ouafa Tahiri; Laghrib, F.; Farahi, A.; Bakasse, M.; Saqrane, S.; Lahrich, S.; Mhammedi, M.A. El

doi:10.1016/j.crfs.2022.02.005

Cited by 13 publications

(3 citation statements)

References 200 publications

(223 reference statements)

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“…Water samples were collected from four representative sampling sites: two in a spring and two in surface streams that cross the avocado plots. In addition, two samples of locally produced avocado fruit were taken and the multiresidue pesticides were determined with QuEChERS extraction, by liquid chromatography tandem mass spectrometry (LC-MS/ MS) (Aghris et al, 2022).…”

Section: Analysis Of Pesticide Residues In the Fruit Pulp And In The ...mentioning

confidence: 99%

Avocado (Persea americana Mill.) production in Huatusco, Veracruz, Mexico

Castillo

Rojas²,

Monterroso-Rivas³

et al. 2023

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Objective: To characterize the avocado production system in Huatusco, Veracruz. Design/Methodology/Approach: Interviews based on the snowball method were applied to avocado producers in Huatusco, Veracruz. Meanwhile, fruit and water samples were used to perform a multiresidue analysis of pesticides. Results: The monoculture plantations are rainfed. They have a density of 100-150 trees ha-1. The Hass variety predominates in Andosols, with 5-100% slopes. Most of the producers (92%) carry out conventional management, applying pesticides and chemical fertilizers. Herbicides and brushcutters are used to control weeds. No pesticides were detected in the water samples, while Imidacloprid, Thiabendazole, and alpha-Cypermethrin were identified in a fruit sample, with 0.0038 ± 0.0014 mg/kg, 0.0022 ± 0.0009 mg/kg and 0.0703 ± 0.000 mg /kg concentrations, respectively. These concentrations fall within the limits allowed in Mexico. Study Limitations/Implications: A detailed and frequent sampling of avocado fruits should be carried out to determine pesticide residues. It is also necessary to analyze samples of running water near the orchards to prevent pollution. Findings/Conclusions: The empirical knowledge of the producers about the type of soil is more precise than the scientific classification: they identify five classes of soils beyond Andosols. Additionally, there is a marked inequality in land tenure, since large-scale producers (25% of all producers) own 86% of the established area. Although, in a preliminary sampling, pesticide concentrations did not exceed the limits of residues allowed in the avocado pulp, the number of pesticide applications should be reduced.

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Section: Analysis Of Pesticide Residues In the Fruit Pulp And In The ...mentioning

confidence: 99%

Avocado (Persea americana Mill.) production in Huatusco, Veracruz, Mexico

Castillo

Rojas²,

Monterroso-Rivas³

et al. 2023

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“…Pesticides are common agricultural chemicals used to control pests, and thereby, increase the crop yield. Their uses are not limited to the agricultural field, but they are also used to control mosquitoes, mice and harmful insects in houses and workplaces [ 1 , 2 ]. For this reason, the investigation of the negative effects of these substances, which are abundant in the surrounding environment, on off-target organisms is among the popular topics of today’s modern life.…”

Section: Introductionmentioning

confidence: 99%

“…However, due to the widespread use of FLB, the environmental risks and food safety have become major concerns. Therefore, it is important to develop fast and practical methods for the detection of residual FLB in the environment [ 2 ]. Although it is known to have a low toxicity potential, it has been shown in recent years that it causes morphological anomalies and neurotoxic effects on different non-target organisms [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Cyto-Genotoxic and Behavioral Effects of Flubendiamide in Allium cepa Root Cells, Drosophila melanogaster and Molecular Docking Studies

Çiğerci

Liman

İstifli

et al. 2023

IJMS

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Flubendiamide (FLB) is an insecticide that is commonly employed to control pests on a variety of vegetables and fruits, with low toxicity for non-target organisms. However, due to its widespread use, the environmental risks and food safety have become major concerns. In this study, the toxicity potential of FLB was studied in the model organisms, Allium cepa and Drosophila melanogaster. The cyto-genotoxic effects of FLB on the root growth, mitotic index (MI), chromosomal aberrations (CAs) and deoxyribonucleic acid (DNA) damage in A. cepa root meristematic cells were investigated using the root growth inhibition Allium test and Comet assays. FLB caused CAs in the form of disturbed ana-telophase, chromosome laggards, stickiness, anaphase-bridge and polyploidy depending on the concentration and the exposure time. The toxicity and genotoxicity of FLB at various doses (0.001, 0.01, 0.1 and 1 mM) on D. melanogaster were investigated from the point of view of larval weight and movement, pupal formation success, pupal position, emergence success and DNA damage, respectively. FLB exposure led to a significant reduction of the locomotor activity at the highest concentration. While DNA damage increased significantly in the FLB-treated onions depending on the concentration and time, DNA damage in the FLB-treated D. melanogaster significantly increased only at the highest dose compared to that which occurred in the control group. Moreover, to provide a mechanistic insight into the genotoxic and locomotion-disrupting effects of FLB, molecular docking simulations of this pesticide were performed against the DNA and diamondback moth (DBM) ryanodine receptor (RyR) Repeat34 domain. The docking studies revealed that FLB binds strongly to a DNA region that is rich in cytosine-guanine-adenine bases (C-G-A) in the minor groove, and it displayed a remarkable binding affinity against the DBM RyR Repeat34 domain.

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Embryonic Flubendiamide Exposure Alters Expression of OTX2 and Other Early Regulators in Domestic Chick Leading to Congenital Eye Defects

Danes,

Parmar,

Vaishnav

et al. 2024

J Biochem & Molecular Tox

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Flubendiamide, a phthalic acid diamide insecticide, has been implicated in potential teratogenic effects on non‐target organisms, especially during embryonic development. This study examines the impact of flubendiamide on eye development in chick embryos, a well‐established model for vertebrate development. Exposure to 0.5 µg/µL of flubendiamide significantly impaired early ocular morphogenesis, resulting in severe defects such as underdeveloped optic cups and the absence of lens and corneal structures. Histopathological analysis demonstrated disrupted optic cup differentiation, while in silico docking studies revealed strong interactions between flubendiamide and key oculogenic proteins, including OTX2, PAX6, and SOX2. These interactions were associated with altered expression patterns of these critical regulators, alongside overexpression of SHH and downregulation of BMP4, BMP7, and FGF8, which are essential for optic vesicle formation and lens differentiation. Additionally, increased CASPASE‐3 expression indicated enhanced apoptosis, contributing to the observed ocular anomalies. These findings suggest that flubendiamide disrupts key signaling pathways necessary for proper eye development, potentially leading to congenital eye defects. The study highlights the need for a thorough evaluation of the molecular mechanisms driving flubendiamide‐induced teratogenicity to ensure safer pesticide use and protect environmental and human health.

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Extraction and determination of flubendiamide insecticide in food samples: A review

Cited by 13 publications

References 200 publications

Avocado (Persea americana Mill.) production in Huatusco, Veracruz, Mexico

Avocado (Persea americana Mill.) production in Huatusco, Veracruz, Mexico

Cyto-Genotoxic and Behavioral Effects of Flubendiamide in Allium cepa Root Cells, Drosophila melanogaster and Molecular Docking Studies

Embryonic Flubendiamide Exposure Alters Expression of OTX2 and Other Early Regulators in Domestic Chick Leading to Congenital Eye Defects

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