Extraction of antioxidant compounds from the wastes of Mangifera pajang fruit: a comparative study using aqueous ethanol and deep eutectic solvent

Ling, Jordy Kim Ung; Chan, Yen San; Nandong, Jobrun

doi:10.1007/s42452-020-3153-x

Cited by 16 publications

(12 citation statements)

References 54 publications

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“…The extraction was conducted based on optimum parameters obtained from previous study (Ling, Chan, & Nandong, 2020). Briefly, 0.5 g of peel powders and 0.5 g of kernel powders were mixed with 30 ml of 54% aqueous ethanol and extracted for 2 h at 51 using an incubator shaker (SASTEC) which set at a speed of 178 rpm.…”

Section: Extraction Of Antioxidant Compounds From Fruit Wastes Of M Pajangmentioning

confidence: 99%

Formulation of choline chloride/ascorbic acid natural deep eutectic solvent: Characterization, solubilization capacity and antioxidant property

Ling

Chan

Nandong

et al. 2020

LWT

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In the present study, natural deep eutectic solvent composed of choline chloride and ascorbic acid (CHCL/AA NADES) was formulated for enhancing the solubility and antioxidant properties of antioxidant extracts from fruit wastes of Mangifera pajang. The solubilities of Mangifera pajang's antioxidant extracts in water and CHCL/AA NADES at different water contents (0 -50 wt%) were investigated. It was observed that the antioxidant extracts were most soluble in the CHCL/AA NADES with 10 wt% of water, and the concentration of antioxidant was found to be approximately 15% and 4% as compared to water and pure CHCL/AA NADES, respectively. The positive effect of water on NADES can be related to the reduced viscosity of NADES, where the viscosity decreased up to 74% upon addition of water. Aside from that, all the tested CHCL/AA NADES enhanced the antioxidant capacity of antioxidant extracts by 1.3-14.64% compared to the antioxidant extracts in water. This finding highlights the role of CHCL/AA NADES as an antioxidant capacity enhancer.Noteworthy, the antioxidant extracts solubilized in the CHCL/AA NADES system formed a nano-scale cluster structure, as depicted by the TEM image, suggesting that the CHCL/AA NADES could potentially use in nanoformulation that provides protection to the antioxidant extracts.

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Section: Extraction Of Antioxidant Compounds From Fruit Wastes Of M Pajangmentioning

confidence: 99%

Formulation of choline chloride/ascorbic acid natural deep eutectic solvent: Characterization, solubilization capacity and antioxidant property

Ling

Chan

Nandong

et al. 2020

LWT

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“…Usually, DESs consist of two components, a hydrogen bond acceptor (HBA) and a hydrogen bond donor (HBD). Choline chloride (ChCl) is the most widely studied HBA, while different polyalcohols, organic acids, sugars, and amino acids have been employed as HBDs [ 4 , 6 , 11 , 12 ]. The possible combinations of HBAs and HBDs are almost unlimited, giving the ability to design task-specific DESs [ 6 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, high viscosity is one of the most important drawbacks in the exploitation of DESs as extractants at an industrial scale. To reduce the viscosity and enhance the mass transport phenomena of the biomolecules from the solid to the liquid, water, an abundant natural substance, is frequently added in various ratios, also influencing the polarity of the DESs and affecting the dissolution of the compounds of interest [ 12 , 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

Extraction of Bioactive Compounds from C. vulgaris Biomass Using Deep Eutectic Solvents

et al. 2023

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C. vulgaris microalgae biomass was employed for the extraction of valuable bioactive compounds with deep eutectic-based solvents (DESs). Particularly, the Choline Chloride (ChCl) based DESs, ChCl:1,2 butanediol (1:4), ChCl:ethylene glycol (1:2), and ChCl:glycerol (1:2) mixed with water at 70/30 w/w ratio were used for that purpose. The extracts’ total carotenoid (TCC) and phenolic contents (TPC), as well as their antioxidant activity (IC50), were determined within the process of identification of the most efficient solvent. This screening procedure revealed ChCl:1,2 butanediol (1:4)/H2O 70/30 w/w as the most compelling solvent; thus, it was employed thereafter for the extraction process optimization. Three extraction parameters, i.e., solvent-to-biomass ratio, temperature, and time were studied regarding their impact on the extract’s TCC, TPC, and IC50. For the experimental design and process optimization, the statistical tool Response Surface Methodology was used. The resulting models’ predictive capacity was confirmed experimentally by carrying out two additional extractions under conditions different from the experimental design.

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“…When comparing viscosity of CHCL:glycerol and CHCL:ethylene glycol at molar ratio of 1:2, it was realized that the neat CHCL:glycerol DES has a relatively lower viscosity (376 cP) as compared to CHCL:ethylene glycol DES (36 cP). This is likely due to the presence of a higher number of -OH groups in the glycerol, which induces stronger hydrogen bonding interaction between the HBA and HBD components [ 27 ]. Even so, the viscosity of the polyol-based DES was comparatively lower than sugar-based and carboxylic acid-based DES, e.g., CHCL:glucose DES (9037 cP), CHCL: malonic acid DES (721 cP), CHCL:oxalic acid DES (231 cP), CHCL:ascorbic acid DES (51,570 cP), etc., as presented in Table 1 .…”

Section: Des As Extraction Solventmentioning

confidence: 99%

“…Additionally, compared to ionic liquid, DES is generally safer, exhibits superior biodegradability, and is more cost-effective to prepare as it is made from natural compounds [ 4 ]. At present, DESs have been used in wide-ranging applications, including electrodeposition [ 5 , 6 , 7 , 8 , 9 ], synthesis of nanomaterials [ 10 , 11 , 12 , 13 ], biotransformation [ 14 , 15 , 16 , 17 , 18 , 19 ], synthesis of pharmaceuticals and drug delivery systems [ 20 , 21 , 22 , 23 , 24 , 25 ], and extraction of bioactive compounds [ 2 , 26 , 27 , 28 , 29 , 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Deep Eutectic Solvent as Green Solvent in Extraction of Biological Macromolecules: A Review

Ling

Hadinoto

2022

IJMS

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Greater awareness of environmental sustainability has driven many industries to transition from using synthetic organic solvents to greener solvents in their manufacturing. Deep eutectic solvents (DESs) have emerged as a highly promising category of green solvents with well-demonstrated and wide-ranging applications, including their use as a solvent in extraction of small-molecule bioactive compounds for food and pharmaceutical applications. The use of DES as an extraction solvent of biological macromolecules, on the other hand, has not been as extensively studied. Thereby, the feasibility of employing DES for biomacromolecule extraction has not been well elucidated. To bridge this gap, this review provides an overview of DES with an emphasis on its unique physicochemical properties that make it an attractive green solvent (e.g., non-toxicity, biodegradability, ease of preparation, renewable, tailorable properties). Recent advances in DES extraction of three classes of biomacromolecules—i.e., proteins, carbohydrates, and lipids—were discussed and future research needs were identified. The importance of DES’s properties—particularly its viscosity, polarity, molar ratio of DES components, and water addition—on the DES extraction’s performance were discussed. Not unlike the findings from DES extraction of bioactive small molecules, DES extraction of biomacromolecules was concluded to be generally superior to extraction using synthetic organic solvents.

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Extraction of antioxidant compounds from the wastes of Mangifera pajang fruit: a comparative study using aqueous ethanol and deep eutectic solvent

Cited by 16 publications

References 54 publications

Formulation of choline chloride/ascorbic acid natural deep eutectic solvent: Characterization, solubilization capacity and antioxidant property

Formulation of choline chloride/ascorbic acid natural deep eutectic solvent: Characterization, solubilization capacity and antioxidant property

Extraction of Bioactive Compounds from C. vulgaris Biomass Using Deep Eutectic Solvents

Deep Eutectic Solvent as Green Solvent in Extraction of Biological Macromolecules: A Review

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