Extraction of carboxylated nanocellulose from oat husk: Characterization, surface modification and in vitro evaluation of indomethacin drug release

Dehkhoda, Sahar; Bagheri, Maryam; Heydari, Mojgan; Rabieh, Sasan

doi:10.1016/j.ijbiomac.2022.05.125

Cited by 21 publications

(8 citation statements)

References 39 publications

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“…To delve further into the release mechanism, the release behavior of FLO and the FLO/β-CD complex in pure water was fitted with four kinetic models, with Higuchi consistently presenting the best correlation parameters, R 2 , exceeding 0.99 in all cases (Table S6). This indicates that the release of both FLO and its complex with β-CD is predominantly governed by a diffusion mechanism, wherein the migration of drug molecules from the solid carrier to the solution phase is driven by a stable diffusion process through concentration gradients. , …”

Section: Resultsmentioning

confidence: 99%

“…This indicates that the release of both FLO and its complex with β-CD is predominantly governed by a diffusion mechanism, wherein the migration of drug molecules from the solid carrier to the solution phase is driven by a stable diffusion process through concentration gradients. 46,47 By evaluating the solubility of FLO and its complex with β-CD in pure water at various temperatures, we unveiled a significant solubility enhancement effect. Specifically, the solubility of the FLO/β-CD complex at 15, 25, and 35 °C was respectively 7.39, 5.89, and 4.94 times higher than that of FLO alone (Figure 8d).…”

Section: Ternary Phase Diagram Of Inclusion Complexesmentioning

confidence: 99%

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Structural Elucidation and Release Enhancement of the Florfenicol/β-Cyclodextrin Inclusion Complex

Xiao,

Shi,

Jia

et al. 2024

Crystal Growth & Design

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The limited aqueous solubility and dissolution rate of Florfenicol (FLO) constrain its therapeutic efficacy. In this study, we enhance these properties by forming an inclusion complex with β-cyclodextrin (β-CD). Employing a cooling-based solution method, the FLO/β-CD complex was synthesized, which was verified to have a stoichiometry of 1:2 through combined nuclear magnetic resonance proton spectra and single-crystal structural analysis. A ternary phase diagram guided our development of a green synthesis route for the pure complex, leveraging slow solvent evaporation and cooling techniques. Significantly, we demonstrate that at temperatures of 10, 25, and 35 °C, the complex markedly improves FLO's solubility and dissolution rate. This work not only offers a valuable strategy to overcome the challenges associated with FLO's bioavailability but also provides insightful guidance for the industrial-scale production of high-purity FLO/β-CD complexes, presenting an advancement in the formulation of poorly soluble pharmaceutical compounds.

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Section: Resultsmentioning

confidence: 99%

Section: Ternary Phase Diagram Of Inclusion Complexesmentioning

confidence: 99%

Structural Elucidation and Release Enhancement of the Florfenicol/β-Cyclodextrin Inclusion Complex

Xiao,

Shi,

Jia

et al. 2024

Crystal Growth & Design

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“…[38] However, indomethacin's hydrophobicity and inability to tolerate alkaline environments renders the use of it as a topical drug difficult. [39] Augusto de Castro et al addressed the issue of bioavailability by creating a poloxamer-based thermoresponsive gel consisting of both hyaluronic acid (HA) and indomethacin. [30] Essentially, at room temperature indomethacin is trapped inside the nanomicelle.…”

Section: Corneal Chemical Burnmentioning

confidence: 99%

“…In the treatment of corneal chemical burn, indomethacin, a nonsteroidal anti‐inflammatory (NSAID) drug, provides potent anti‐inflammatory effects through the inhibition of cyclooxygenase‐2 enzymes (COX‐2) [38] . However, indomethacin's hydrophobicity and inability to tolerate alkaline environments renders the use of it as a topical drug difficult [39] . Augusto de Castro et al.…”

Section: Ophthalmic Applications Of Hydrogelsmentioning

confidence: 99%

Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications

Kulbay,

Wu,

Truong

et al. 2024

Smart Molecules

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This comprehensive review delves into a unique intersection of hydrogels as smart molecules and their transformative applications in ophthalmology. Beginning with the foundational definition, properties, and classification of hydrogels, the review explores their synthesis and responsive capabilities. Specific applications examined encompass topical drug delivery, contact lenses, intravitreal drug delivery, ocular adhesives, vitreous substitutes, and cell‐based therapy. A methodical analysis, including an overview of relevant ocular structures and a comparative evaluation of hydrogel‐based solutions against traditional treatments, is conducted. Additionally, potential constraints, translation challenges, knowledge gaps, and research areas are identified. Our methodical approach, guided by an extensive literature review from 2017 to 2023, illuminates the unprecedented opportunities offered by hydrogels, along with pinpointing areas for further inquiry to facilitate their transition into clinical practice.

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“…However, pristine CNCs possess several disadvantages as drug carriers, such as their thermal and pH stability and solubility. The high hydrophilicity of pristine CNCs limits their application as hydrophilic drug carriers [ 5 ]. Changing the surface chemistry of CNCs through surface modification processes will make the CNCs more practical for delivering both hydrophilic and hydrophobic drugs.…”

Section: Introductionmentioning

confidence: 99%

Cellulose Nanocrystals (CNCs) and Its Modified Form from Durian Rind as Dexamethasone Carrier

et al. 2022

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In this study, CNCs were extracted from durian rind. Modification to CNCs with saponin was conducted at 50 °C for one h. CNCs and CNCs-saponin were employed as dexamethasone carriers. Modification to CNCs using saponin did not change the relative crystallinity of CNCs. CNCs’ molecular structure and surface chemistry did not alter significantly after modification. Both nanoparticles have surface charges independently of pH. Dexamethasone-released kinetics were studied at two different pH (7.4 and 5.8). Higuchi, Ritger–Peppas, first-order kinetic and sigmoidal equations were used to represent the released kinetic data. The sigmoidal equation was found to be superior to other models. The CNCs and CNCs-saponin showed burst release at 30 min. The study indicated that cell viability decreased by 30% after modification with saponin.

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Extraction of carboxylated nanocellulose from oat husk: Characterization, surface modification and in vitro evaluation of indomethacin drug release

Cited by 21 publications

References 39 publications

Structural Elucidation and Release Enhancement of the Florfenicol/β-Cyclodextrin Inclusion Complex

Structural Elucidation and Release Enhancement of the Florfenicol/β-Cyclodextrin Inclusion Complex

Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications

Cellulose Nanocrystals (CNCs) and Its Modified Form from Durian Rind as Dexamethasone Carrier

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