Extraction of flavonoids from <i>Citri Reticulatae Pericarpium Viride</i> using a deep eutectic solvent

Li, Gang; Lei, Jie; Li, Sihui; Jiang, Yongmei; Zhang, Feng; Song, Changwei; Xiao, Shiji; Fu, Shulan; Zhou, Jinquan; Wu, Faming; Wang, Gang

doi:10.1039/d2ra04276b

Cited by 9 publications

(4 citation statements)

References 30 publications

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“…31,32 2.5 Antioxidant test 2.5.1 DPPH method. DPPH-scavenging capacity was determined with reference to Wang et al, 33 eight-10 mL test tubes with plugs were used to extract 2 mL crude myricetin of 2, 4, 6, 8, 10, 12, 14, and 16 mg mL −1 of myricetin (1.3.4 extraction of myricetin). Next, 2 mL of DPPH solution (6.34 × 10 −4 mmol L −1 ) was added to each stoppered test tube, shaken well, and allowed to stand for 30 min away from light.…”

Section: Separation and Purication Of Myricetinmentioning

confidence: 99%

Deep eutectic solvent extraction of myricetin and antioxidant properties

Liu,

Guo,

Miao

et al. 2024

RSC Adv.

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Section: Separation and Purication Of Myricetinmentioning

confidence: 99%

Deep eutectic solvent extraction of myricetin and antioxidant properties

Liu,

Guo,

Miao

et al. 2024

RSC Adv.

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“…Different NADESs have different physical properties, such as viscosity, density, etc., which greatly affect the extraction of natural products. Viscosity is a key factor affecting the extraction effect [30]. High viscosity will reduce the mass transfer rate of the solvent and reduce the extraction efficiency of natural products [31].…”

Section: Screening Of Nadesmentioning

confidence: 99%

Ultrasound-Assisted Extraction of Phenolic Compounds from Celtuce (Lactuca sativa var. augustana) Leaves Using Natural Deep Eutectic Solvents (NADES): Process Optimization and Extraction Mechanism Research

Li,

Wang,

Zhao

et al. 2024

Molecules

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Natural deep eutectic solvents (NADESs), as emerging green solvents, can efficiently extract natural products from natural resources. However, studies on the extraction of phenolic compounds from celtuce (Lactuca sativa var. augustana) leaves (CLs) by NADESs are still lacking. This study screened the NADES L-proline-lactic acid (Pr-LA), combined it with ultrasound-assisted extraction (UAE) to extract phenolic compounds from CLs, and conducted a comparative study on the extraction effect with traditional extraction solvents. Both SEM and FT-IR confirmed that Pr-LA can enhance the degree of fragmentation of cell structures and improve the extraction rate of phenolic compounds. Molecular dynamics simulation results show that Pr-LA can improve the solubility of phenolic compounds and has stronger hydrogen bonds and van der Waals interactions with phenolic compounds. Single-factor and Box–Behnken experiments optimized the process parameters for the extraction of phenolic compounds from CLs. The second-order kinetic model describes the extraction process of phenolic compounds from CLs under optimal process parameters and provides theoretical guidance for actual industrial production. This study not only provides an efficient and green method for extracting phenolic compounds from CLs but also clarifies the mechanism of improved extraction efficiency, which provides a basis for research on the NADES extraction mechanism.

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“…Polyhydroxy natural products belong to a class of plant compounds that contain multiple phenolic hydroxyl or hydroxyl groups. These compounds, which include flavonoids, tannins, phenolic acids, and anthocyanins, are found in numerous common plant foods like cacao nibs, tea, soybeans, red wine, vegetables, and fruits. − These natural medicines have various health-promoting effects, such as antioxidantion, promotion of vasodilation, and prevention of diseases like atherosclerosis, coronary heart disease, and myocardial infarction. − However, these drugs suffer from poor water solubility, instability, and low bioavailability and hence have limited applications. , Cocrystallization is an effective strategy for modifying the physicochemical properties of such natural medicines. ,, …”

Section: Introductionmentioning

confidence: 99%

Uncovering Cocrystal Formation and Competition Mechanism of Polyhydroxy Natural Products: Cases of Quercetin, Hesperidin, Resveratrol, and Curcumin

Li,

Chen,

Zhou

et al. 2024

Crystal Growth & Design

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Understanding drug cocrystal formation and its competitive mechanism is important for improving the physicochemical properties of drugs. In this article, the cocrystal formation of polyhydroxy natural products and their competitive mechanisms are discussed through experimental screening and theoretical calculations. The formation conditions and types of cocrystals were determined based on efficient screening experiments of polyhydroxy natural product cocrystals. To investigate the difficulty and stability of cocrystal formation, competitive cocrystal experiments of polyhydroxy natural products were carried out simultaneously. By simulation of the electrostatic potential surface of molecules and the Hirshfeld surface of crystals, the mode of hydrogen bonding within the crystals was determined. The strength of hydrogen bonding was assessed based on the intermolecular interactions and energy framework within the crystal structure. A “substitution model” was constructed based on experimental results and theoretical calculations, which is of great significance for the prediction and design of natural product cocrystals and provides a feasible solution for improving the physicochemical properties of drugs.

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Extraction of flavonoids from Citri Reticulatae Pericarpium Viride using a deep eutectic solvent

Abstract: Flavonoids are the main active ingredient in Citri Reticulatae Pericarpium Viride (CRPV).

Cited by 9 publications

References 30 publications

Deep eutectic solvent extraction of myricetin and antioxidant properties

Deep eutectic solvent extraction of myricetin and antioxidant properties

Ultrasound-Assisted Extraction of Phenolic Compounds from Celtuce (Lactuca sativa var. augustana) Leaves Using Natural Deep Eutectic Solvents (NADES): Process Optimization and Extraction Mechanism Research

Uncovering Cocrystal Formation and Competition Mechanism of Polyhydroxy Natural Products: Cases of Quercetin, Hesperidin, Resveratrol, and Curcumin

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