Extraction of Flavonoids From Natural Sources Using Modern Techniques

Chaves, Jaísa Oliveira; Souza, Mariana C.; Silva, Laíse Capelasso da; Lachos‐Perez, Daniel; Torres-Mayanga, Paulo César; Machado, Ana Paula da Fonseca; Forster‐Carneiro, Tânia; Vázquez-Espinosa, Mercedes; González-de-Peredo, Ana V.; Barbero, Gerardo F.; Rostagno, Maurı́cio A.

doi:10.3389/fchem.2020.507887

Cited by 335 publications

(257 citation statements)

References 191 publications

(278 reference statements)

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“…The sample–solvent ratio is also a crucial factor with regards to production capacity since they have a direct influence on the cavitation phenomenon and on the final concentration of the extracts [ 46 ]. According to Chaves et al [ 47 ], when the objective of the extraction is the preparation of samples for quantitative analysis, high solvent ratios (1:50, 1:100, or even higher) may be required to ensure that the target compounds are entirely removed from the sample matrix.…”

Section: Resultsmentioning

confidence: 99%

Flavonol Composition and Antioxidant Activity of Onions (Allium cepa L.) Based on the Development of New Analytical Ultrasound-Assisted Extraction Methods

et al. 2021

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The onion is one of the most cultivated and consumed vegetables, and is a very valuable source of antioxidant substances. Every onion variety is rich in flavonols—mainly quercetin derivatives which makes onions the main dietary source of these compounds. This study intends to develop an ultrasound-assisted extraction method (UAE), an economical, green, and efficient technique, that allows us to determine the quality of onion extracts in terms of flavonol composition and antioxidant activity. For this purpose, an ultrasound-assisted extraction method has been optimized to obtain extracts with a high amount of flavonols, as well as with a high antioxidant activity, not only separately using a Box–Behnken design, but also simultaneously, based on multi-response optimization. Multiple response optimization has not only demonstrated an efficacy level similar to that of the individual ones, but it also represents a considerable reduction in terms of cost, time and work. The optimal conditions for simultaneous extractions were determined as follows: 76.8% methanol as an extraction solvent at pH 2 and 58.5 °C temperature, 85% amplitude, 0.9 s cycle, and 0.2:13 g:mL sample mass/solvent volume ratio. Furthermore, the developed method exhibited a high precision level and great recoveries in a rather short extraction time (2 min). These results, together with the development of a fast and simple UHPLC analysis method, lead us to consider the developed UAE method as a suitable technique for the extraction of bioactive compounds from onion matrices.

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Section: Resultsmentioning

confidence: 99%

Flavonol Composition and Antioxidant Activity of Onions (Allium cepa L.) Based on the Development of New Analytical Ultrasound-Assisted Extraction Methods

et al. 2021

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“…The phase equilibrium plays an essential role during the designing of a highly sensitive process with too many operating conditions to be followed. A large amount of pressure and environmental conditions also need to be met for the initiation of separation studies (Chaves et al 2020).…”

Section: Supercritical Fluid Extractionmentioning

confidence: 99%

Techniques and modeling of polyphenol extraction from food: a review

et al. 2021

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There is a growing demand for vegetal food having health benefits such as improving the immune system. This is due in particular to the presence of polyphenols present in small amounts in many fruits, vegetables and functional foods. Extracting polyphenols is challenging because extraction techniques should not alter food quality. Here, we review technologies for extracting polyphenolic compounds from foods. Conventional techniques include percolation, decoction, heat reflux extraction, Soxhlet extraction and maceration, whereas advanced techniques are ultrasound-assisted extraction, microwave-assisted extraction, supercritical fluid extraction, high-voltage electric discharge, pulse electric field extraction and enzyme-assisted extraction. Advanced techniques are 32-36% more efficient with approximately 15 times less energy consumption and producing higher-quality extracts. Membrane separation and encapsulation appear promising to improve the sustainability of separating polyphenolic compounds. We present kinetic models and their influence on process parameters such as solvent type, solid and solvent ratio, temperature and particle size.

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“…Microwaves consist of electric and magnetic fields that oscillate perpendicularly to each other in a high-frequency range from 0.3 to 300 GHz [24,32]. This condition produces localized heating and causes the destruction of the plant matrix leading, to the easier diffusion of the compounds of interest into the solvent [28,32]. A microwave power between 300 and 900 W and extraction temperatures ranging from 50 to 100 • C are generally used [19].…”

Section: Microwave-assisted Extraction (Mae)mentioning

confidence: 99%

“…Regarding the extraction conditions, studies have shown that ASE is more efficient when mixtures of solvents are used, such as methanol or ethanol in water, instead of pure solvents [19], for the reasons of polarity compatibility. Working pressures ranging from 4 to 20 MPa affect the diffusion of the solvent into the pores of the raw material matrix, enhancing the contact of the target compounds with the solvent [32,38]. Temperature is also an important parameter of ASE extraction.…”

Section: Accelerated Solvent Extraction (Ase)mentioning

confidence: 99%

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Advanced Analytical Approaches for the Analysis of Polyphenols in Plants Matrices—A Review

et al. 2021

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Phenolic compounds are plants’ bioactive metabolites that have been studied for their ability to confer extensive benefits to human health. As currently there is an increased interest in natural compounds identification and characterization, new analytical methods based on advanced technologies have been developed. This paper summarizes current advances in the state of the art for polyphenols identification and quantification. Analytical techniques ranging from high-pressure liquid chromatography to hyphenated spectrometric methods are discussed. The topic of high-resolution mass spectrometry, from targeted quantification to untargeted comprehensive chemical profiling, is particularly addressed. Structure elucidation is one of the important steps for natural products research. Mass spectral data handling approaches, including acquisition mode selection, accurate mass measurements, elemental composition, mass spectral library search algorithms and structure confirmation through mass fragmentation pathways, are discussed.

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Extraction of Flavonoids From Natural Sources Using Modern Techniques

Cited by 335 publications

References 191 publications

Flavonol Composition and Antioxidant Activity of Onions (Allium cepa L.) Based on the Development of New Analytical Ultrasound-Assisted Extraction Methods

Flavonol Composition and Antioxidant Activity of Onions (Allium cepa L.) Based on the Development of New Analytical Ultrasound-Assisted Extraction Methods

Techniques and modeling of polyphenol extraction from food: a review

Advanced Analytical Approaches for the Analysis of Polyphenols in Plants Matrices—A Review

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