Since its introduction in 1962, the Newman-Penrose formalism has been widely used in analytical and numerical studies of Einstein's equations, like for example for the Teukolsky master equation, or as a powerful wave extraction tool in numerical relativity. Despite the many applications, Einstein's equations in the Newman-Penrose formalism appear complicated and not easily applicable to general studies of spacetimes, mainly because physical and gauge degrees of freedom are mixed in a nontrivial way. In this paper we approach the whole formalism with the goal of expressing the spin coefficients as functions of tetrad invariants once a particular tetrad is chosen. We show that it is possible to do so, and give for the first time a general recipe for the task, as well as an indication of the quantities and identities that are required. Since its introduction the Newman-Penrose (NP) formalism proved to be a powerful approach to Einstein's equations studied in several areas of general relativity. In 1973 Teukolsky [3] formulated his famous master equation based on the NP formalism giving decoupled perturbation equations for two Weyl scalars Ψ 0 and Ψ 4 . This strengthened the idea of these scalar fields being associated with the gravitational waves degrees of freedom, respectively ingoing and outgoing, a result that had been already anticipated by Newman and Penrose in their seminal paper.With the advent of numerical relativity the NP formalism found another important application: a tool for gravitational wave extraction in numerical simulations (for an exhaustive review on wave extraction methods see [4]). Given its tight association to the gravitational wave degrees of freedom and its coordinate invariant properties, the calculation of Ψ 4 in a numerical grid seemed to be the most natural candidate for a rigorous wave extraction methodology. However, the freedom in the choice of tetrads constitutes a possible source of undesired gauge effects, which led to a series of papers on the topic aimed at finding the most rigorous approach. The main motivation underlying these works was to define a gauge invariant quantity associated with gravitational waves. Beetle and Burko [5] published a paper in 2002 identifying a radiation scalar with interesting properties for * Electronic address: andrea.nerozzi@ist.utl.pt wave extraction, following a previous work by Baker and Campanelli [6] which proposed that a certain function of curvature invariants, the speciality index, could be studied as an invariant measure of distortions of spacetimes. These works were soon followed by a series of papers in the field aiming to identify an optimal tetrad in which to calculate Ψ 4 (or Ψ 0 for ingoing waves). This special choice was named the "quasi-Kinnersley" tetrad [7][8][9][10] because of its natural property of converging to the Kinnersley tetrad [11] in the single black hole limit. This tetrad was found to be part of a particular set of tetrads that were dubbed "transverse" tetrads, namely those in which Ψ 1 = Ψ 3 = 0. Incidentally thi...