Extraction of Ibuprofen from Natural Waters Using a Covalent Organic Framework

Abstract

<jats:p>Ibuprofen is one of the most widely used pharmaceuticals, and due to its inefficient removal by conventional wastewater treatment, it can be found in natural surface waters at high concentrations. Recently, we demonstrated that the TpBD-(CF3)2 covalent organic framework (COF) can adsorb ibuprofen from ultrapure water with high efficiency. Here, we investigate the performance of the COF for the extraction of ibuprofen from natural water samples from a lake, river, and estuary. In general, the complexity of the natural water matrix induced a reduction in the adsorption efficiency of ibuprofen as compared to ultrapure water. The best performance, with over 70% adsorption efficiency, was found in lake water, the sample which featured the lowest pH. According to the theoretical calculations, ibuprofen more favorably interacts with the COF pores in the protonated form, which could partially account for the enhanced adsorption efficiency found in lake water. In addition, we explored the effect of the presence of competing pharmaceuticals, namely, acetaminophen and phenobarbital, on the ibuprofen adsorption as binary mixtures. Acetaminophen and phenobarbital were adsorbed by TpBD-(CF3)2 with low efficiency and their presence led to an increase in ibuprofen adsorption in the binary mixtures. Overall, this study demonstrates that TpBD-(CF3)2 is an efficient adsorbent for the extraction of ibuprofen from natural waters as well.</jats:p>

Covalent Organic Frameworks: Synthesis, Properties and Applications—An Overview

“…Tests of COFs bearing similar structures have also been reported for removal of other pharmaceuticals, mainly NSAIDs [ 108 , 109 , 110 , 111 , 112 , 113 ].…”

Covalent‐Organic Framework Composites: A Review Report on Synthesis Methods

“…The high toxicity, rapid dissemination, and bioaccumulation of mercury has been studied extensively in the environment. Ibuprofen adsorption was recently demonstrated using fluorine‐functionalized bulk COF from ultrapure [208] and natural wastewater samples [209] . Furthermore, various new composites have been identified as effective adsorbents for the removal of diclofenac, [142,210,211] sulfonamides, [212] triclosan and triclocarban [213] from polluted water samples.…”

“…Ibuprofen adsorption was recently demonstrated using fluorine-functionalized bulk COF from ultrapure [208] and natural wastewater samples. [209] Furthermore, various new composites have been identified as effective adsorbents for the removal of diclofenac, [142,210,211] sulfonamides, [212] triclosan and triclocarban [213] from polluted water samples. COF-based membranes have recently been incorporated into advanced water treatment as promising candidates for organic dye nanofiltration.…”

Covalent Organic Framework Composites: Synthesis and Analytical Applications

“…Their abuse and incorrect disposal may result in the presence of these products and their derivatives in the aquatic environment. Recently, fluorine-functionalized bulk COF was shown to be an efficient adsorbent of ibuprofen from both ultrapure [ 98 ] and natural water samples [ 99 ]. A step forward in the application of COFs for contaminant removal is the development of magnetic COF composites, which can improve the adsorbent recovery from the sample matrix.…”