Extraction, purification, structural modification, activities and application of polysaccharides from different parts of mulberry

Wang, Huilin; Huang, Gangliang

doi:10.1039/d3fo05747j

Cited by 19 publications

(2 citation statements)

References 109 publications

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“…It has been found that these polysaccharides effectively reduce pro-inflammatory cytokines such as interleukin (IL)-1b and IL-6 while increasing the levels of the anti-inflammatory cytokine IL-10. This results in the protection of macrophages stimulated by lipopolysaccharide (LPS) from apoptotic cell death by regulating the levels of anti-and pro-apoptotic protein [60].…”

Section: Polysaccharidesmentioning

confidence: 99%

Potential Role and Mechanism of Mulberry Extract in Immune Modulation: Focus on Chemical Compositions, Mechanistic Insights, and Extraction Techniques

Abbas,

Tong,

Wang

et al. 2024

IJMS

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Mulberry is a rapidly growing plant that thrives in diverse climatic, topographical, and soil types, spanning temperature and temperate countries. Mulberry plants are valued as functional foods for their abundant chemical composition, serving as a significant reservoir of bioactive compounds like proteins, polysaccharides, phenolics, and flavonoids. Moreover, these compounds displayed potent antioxidant activity by scavenging free radicals, inhibiting reactive oxygen species generation, and restoring elevated nitric oxide production induced by LPS stimulation through the downregulation of inducible NO synthase expression. Active components like oxyresveratrol found in Morus demonstrated anti-inflammatory effects by inhibiting leukocyte migration through the MEK/ERK signaling pathway. Gallic and chlorogenic acids in mulberry leaves (ML) powder-modulated TNF, IL-6, and IRS1 proteins, improving various inflammatory conditions by immune system modulation. As we delve deeper into understanding its anti-inflammatory potential and how it works therapeutically, it is crucial to refine the extraction process to enhance the effectiveness of its bioactive elements. Recent advancements in extraction techniques, such as solid–liquid extraction, pressurized liquid extraction, superficial fluid extraction, microwave-assisted extraction, and ultrasonic-assisted extraction, are being explored. Among the extraction methods tested, including Soxhlet extraction, maceration, and ultrasound-assisted extraction (UAE), UAE demonstrated superior efficiency in extracting bioactive compounds from mulberry leaves. Overall, this comprehensive review sheds light on the potential of mulberry as a natural immunomodulatory agent and provides insights into its mechanisms of action for future research and therapeutic applications.

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Section: Polysaccharidesmentioning

confidence: 99%

Potential Role and Mechanism of Mulberry Extract in Immune Modulation: Focus on Chemical Compositions, Mechanistic Insights, and Extraction Techniques

Abbas,

Tong,

Wang

et al. 2024

IJMS

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show abstract

“…Polysaccharides are modified into derivatives with different structures, and there are significant differences in their biological activities. Among them, phosphorylation and acetylation are two important methods for polysaccharide modification 1 – 5 . Shaddock skin polysaccharides (SSP) have many physiological functions and have important application prospects for their research and development 6 , 7 .…”

Section: Introductionmentioning

confidence: 99%

Preparation for shaddock skin polysaccharide derivatives by response surface method

Huang,

Lin

2024

Sci Rep

Self Cite

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The derivation of polysaccharide has an important impact on its properties. The preparation process of phosphorylated-shaddock skin polysaccharides (SSP) and acetylated-SSP was optimized by the response surface method. The constructed model was accurate and reliable in predicting the substitution of acetylated-SSP and the phosphate content of phosphorylated-SSP. This method was simple and easy to operate, which provided a basis for the preparation of a large number of derivatives.

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Research Progress on Structure and Bioactivity of Polysaccharides from Platycodon grandiflorum

Chen,

Ji,

et al. 2024

Starch Stärke

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Platycodon grandiflorum is a commonly used Chinese herbal medicine in China, containing saponins, flavonoids, phenolic compounds, fatty acids, volatile oils, polysaccharides, and other active ingredients. It has the effects of regulating immunity, anti‐inflammatory, expectorant, lowering blood lipids, antioxidation, etc., and can be used to treat symptoms such as cough, sore throat, lung pain, and expectoration. Polysaccharides are one of the important bioactive substances in P. grandiflorum, which have better anti‐tumor and enhancing immune activity, and are widely used in medicine, health food, and other fields. P. grandiflorum polysaccharide (PGP) has various biological activities and is the main component and key bioactive substance of P. grandiflorum. It has various biological effects, including immune regulation, antioxidant, anti‐tumor, liver protection, hypoglycemic, and gastrointestinal protection. This paper systematically reviews the research progress on the extraction, separation and purification, structural characteristics, and biological activity of P. grandiflorum polysaccharides in recent years both domestically and internationally, to provide the theoretical basis for improving the utilization of P. grandiflorum polysaccharides and further studying the structure–activity relationship of P. grandiflorum polysaccharides.

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Extraction, purification, structural modification, activities and application of polysaccharides from different parts of mulberry

Abstract: The mulberry plant is a member of the Moraceae family and belongs to the Morus genus. Its entire body is a treasure, with mulberries, mulberry leaves, and mulberry branches all...

Cited by 19 publications

References 109 publications

Potential Role and Mechanism of Mulberry Extract in Immune Modulation: Focus on Chemical Compositions, Mechanistic Insights, and Extraction Techniques

Potential Role and Mechanism of Mulberry Extract in Immune Modulation: Focus on Chemical Compositions, Mechanistic Insights, and Extraction Techniques

Preparation for shaddock skin polysaccharide derivatives by response surface method

Research Progress on Structure and Bioactivity of Polysaccharides from Platycodon grandiflorum

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