Extractive spectrophotometric determination of sulphonamide drugs in pure and pharmaceutical preparations through ion-pair formation with molybdenum(V) thiocyanate in acidic medium

El-Dien, F. A. Nour; Khaled, Elmorsy; Frag, Eman Yossri

doi:10.1016/j.jare.2010.05.005

Cited by 13 publications

(5 citation statements)

References 15 publications

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“…The data obtained are given in Figures (6, 7). The result indicate that a 1:1 Mo(V):GRF ion-pair is formed through the electrostatic attraction between positive protonated drug GRF + and thiocyanate negative complex [Mo(SCN)6]ˉ [21] as shown by the proposed structure (scheme 2). Between-day measurements:…”

Section: Stoichiometry Of the Reaction Of Grf With Tcnq And Mo(v)-thimentioning

confidence: 82%

Two Spectrophotometric Methods for the Determination of Griseofulvin in Tablets

Frag

Mohamed

Alrahmony

2011

Al-Azhar Bulletin of Science

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Two simple and rapid spectrophotometric methods have been described for the assay of griseofulvin (GRF) either in pure form or in pharmaceutical formulations. The first method (A) is based on charge transfer complex reaction using 7,7,8,8-tetracyanoquinodimethane (TCNQ). The complex showed absorbance maximum at 842 nm. Beer's law is obeyed over the concentration range of 5-200 μg mL −1. The second method (B) is based on the formation of coloured ethylenechloride extractable ion-association complex of GRF with Mo(V)thiocyanate with absorption maximum at 470 nm. Beer's law is obeyed in the concentration range of 2-150 μg mL-1. The proposed methods were applied successfully to the determination of the examined drug either in a pure or pharmaceutical dosage forms. No interference was observed from common excipients present in pharmaceutical formulations.

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Section: Stoichiometry Of the Reaction Of Grf With Tcnq And Mo(v)-thimentioning

confidence: 82%

Two Spectrophotometric Methods for the Determination of Griseofulvin in Tablets

Frag

Mohamed

Alrahmony

2011

Al-Azhar Bulletin of Science

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“…2021 -European Journal of Chemistry -CC BY NC -DOI: 10.5155/eurjchem.12.4.368-376.2144 The proposed work has many points of strength in accordance with the principles of green chemistry [42] such as the usage of methanol as an environmentally preferable green solvent throughout the whole work [43]. Also, the proposed procedures offer better sensitivity and simpler data manipulation as compared to the tedious colorimetric methods [15,44,45], i.e. all the proposed methods avoid unnecessary colorimetric derivatization because such steps require additional reagents and can generate waste.…”

Section: Discussionmentioning

confidence: 99%

Universal procedures for spectrophotometric determination of anticoccidial drugs; application to multi-ingredient veterinary formulation and computational investigations for multivariate analysis

et al. 2021

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Simple, accurate, and eco-friendly spectrophotometric procedures were proposed and implemented for simultaneous determination of anticoccidial drugs from three different classes namely, amprolium hydrochloride (AMP), sulfaquinoxaline sodium (SQX) and diaveridine hydrochloride (DVD). Dual wavelength in ratio spectra procedure was proposed where the difference in amplitudes (ΔP) in the ratio spectra at 264 nm and 301.9 nm (ΔP264&301.9 nm) corresponded to AMP with mean percentage recovery 100.00±0.923%, while (ΔP250.9&279 nm) and (ΔP218&243.5 nm) corresponded to SQX and DVD with mean percentage recoveries 99.31±1.083 and 100.64±1.219%, respectively. The dual wavelength in ratio spectra procedure was validated according to the ICH guidelines and accuracy, precision and repeatability were found to be within the acceptable limit. Multivariate chemometric approaches, namely, partial least-squares (PLS-2) and principal component regression (PCR) were also proposed with mean percentage recoveries 99.31±0.769, 98.91±1.192 and 99.04±1.245% for AMP, SQX and DVD, respectively, in PLS-2 and 99.63±1.005, 99.11±1.272 and 98.93±1.338% for AMP, SQX and DVD, respectively, in PCR. These procedures were successfully applied to the multi-ingredient veterinary formulation with mean percentage recoveries 100.75±1.238, 99.29±0.875 and 99.34±0.745% for AMP, SQX and DVD, respectively, in dual wavelength in ratio spectra procedure and 101.03±1.261, 101.48±0.984 and 101.10±1.339% for AMP, SQX and DVD, respectively, in PLS-2 and 100.22±1.204, 101.10±0.546 and 100.91±0.677% for AMP, SQX and DVD, respectively, in PCR.

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“…However, these methods require the drug to be present in the base or acid forms for complexation. For example, typical, some methods based on extractive spectrophotometric are used for the determination of some formulations after selecting the optimum conditions by preliminary experiments, such as pH, buffer, and solvent; at the wavelength of maximum absorption; (a) bromocresol purple used for terbinafine [21,24], nifedipine [50], sulfadimidine, sulfaguanidine, sulfametrole, sulfaquinoxaline, and sulfamethoxazole [51], hydroxyzine dihydrochloride [52], lercanidipine [53], oxomemazine hydrochloride [54], and atorvastatin [55].…”

Section: Ion-pair Complexmentioning

confidence: 99%

Spectrophotometric/Titrimetric Drug Analysis

Qarah¹,

El-Maaiden²

2023

Drug Formulation Design

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The importance of pharmaceuticals comes from their direct connection to human life. Therefore, many analysis techniques such as chromatography, spectroscopic methods, and others have been developed for one goal, which is to ensure that the drug reaches humans with high quality. Spectrophotometric and titrimetric methods have been in general use for the last 40 years and over this period have become the most important analytical instrument in the modern-day laboratory. In many applications, other techniques could be employed in pharmaceutical analysis, but none rival UV–visible spectrometry as well as titrimetry, for their simplicity, versatility, speed, accuracy, and cost-effectiveness. This chapter highlights the spectroscopic methods in the ultraviolet and visible regions, as well as the titration methods that are still widely used in the field of pharmaceutical analysis. The types of titrations, as well as the most important reactions used in spectrophotometric methods, are presented. Examples of the most important applications in the field of pharmaceutical analysis are also presented.

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Extractive spectrophotometric determination of sulphonamide drugs in pure and pharmaceutical preparations through ion-pair formation with molybdenum(V) thiocyanate in acidic medium

Cited by 13 publications

References 15 publications

Two Spectrophotometric Methods for the Determination of Griseofulvin in Tablets

Two Spectrophotometric Methods for the Determination of Griseofulvin in Tablets

Universal procedures for spectrophotometric determination of anticoccidial drugs; application to multi-ingredient veterinary formulation and computational investigations for multivariate analysis

Spectrophotometric/Titrimetric Drug Analysis

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