2022
DOI: 10.21203/rs.3.rs-1764979/v1
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Extracts from Argentinian native plants reverse fluconazole resistance in Candida species by inhibiting the efflux transporters Mdr1 and Cdr1

Abstract: Background: The development of multidrug resistance (MDR) associated with the overexpression of the efflux transporters Mdr1 and Cdr1 in Candida species impedes antifungal therapies. The urgent need for novel agents able to inhibit the function of both pumps, led us to evaluate this property in 137 extracts obtained from Argentinian plants. Methods: The ability of the extracts to reverse efflux pump-mediated MDR was determined with an agar chemosensitization assay using fluconazole (FCZ) resistant Mdr1- and Cd… Show more

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“…In a recent preprint by Gil et al [86] the authors evaluated the ability of selected plant extracts to reverse fluconazole resistance by blocking the efflux transporters Mdr1 and Vdr1 in Candida spp. Aerial parts of L. cuneifolia from the province of Córdoba growing on Lithraea molleoides (Anacardiaceae), Vachellia sp.…”
Section: Ligaria Cuneifoliamentioning
confidence: 99%
“…In a recent preprint by Gil et al [86] the authors evaluated the ability of selected plant extracts to reverse fluconazole resistance by blocking the efflux transporters Mdr1 and Vdr1 in Candida spp. Aerial parts of L. cuneifolia from the province of Córdoba growing on Lithraea molleoides (Anacardiaceae), Vachellia sp.…”
Section: Ligaria Cuneifoliamentioning
confidence: 99%