Extracts from<i>Hericium erinaceus</i>relieve inflammatory bowel disease by regulating immunity and gut microbiota

Chen, Diling; Yang, Xuefei; Chaoqun, Zheng; Yang, Jian; Tang, Xiaocui; Chen, Jun; Shuai, Ou; Xie, Yizhen

doi:10.18632/oncotarget.20689

Cited by 69 publications

(46 citation statements)

References 64 publications

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“…We observed distinct microbial communities within the different groups. Dorea is a potentially pro-inflammatory taxa ( Diling et al, 2017 ), and was significantly increased in C. sinensis infected subjects. This increase was also observed in other helminth infected individuals ( Duarte et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Altered Gut Microbiota Composition in Subjects Infected With Clonorchis sinensis

Jiang

Huang

et al. 2018

Front. Microbiol.

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Clonorchiasis is an infectious disease caused by helminths of Clonorchis sinensis (C. sinensis). The adult parasite mainly inhabits the bile duct and gall bladder, and results in various complications to the hepatobiliary system. The amount of bile secreted into the intestine is reduced in cases of C. sinensis infection, which may alter the pH of the gut and decrease the amount of surfactant protein D released from the gallbladder. However, the impact of parasitic infection on the human gut microbiome remains unclear. To this end, we examined the gut microbiota composition in 47 modified Kato–Katz thick smear-positive (egg-positive) volunteers and 42 healthy controls from five rural communities. Subjects were grouped into four sub-populations based on age and infection status. High-throughput 16S rRNA gene sequencing revealed significant changes in alpha diversity between EP1 and EN1. The beta diversity showed alterations between C. sinensis-infected subjects and healthy controls. In C. sinensis infected patients, we found the significant reduction of certain taxa, such as Bacteroides and anti-inflammatory Bifidobacterium (P < 0.05). Bacteroides, a predominant gut bacteria in healthy populations, was negatively correlated with the number of C. sinensis eggs per gram (EPG, r = −0.37, P adjust < 0.01 in 20–60 years old group; r = −0.64, P adjust = 0.04 in the 60+ years old group). What’s more, the reduction in the abundance of Bifidobacterium, a common probiotic, was decreased particularly in the 60 + years old group (r = −0.50, P = 0.04). The abundance of Dorea, a potentially pro-inflammatory microbe, was higher in infected subjects than in healthy individuals (P < 0.05). Variovorax was a unique bacteria that was only detected in infected subjects. These results clearly demonstrate the significant influence of C. sinensis infection on the human gut microbiota and provided new insights into the control, prevention, diagnosis, and clinical study of clonorchiasis through the human gut microbiota.

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Section: Discussionmentioning

confidence: 99%

Altered Gut Microbiota Composition in Subjects Infected With Clonorchis sinensis

Jiang

Huang

et al. 2018

Front. Microbiol.

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“…31 Further studies assessed the efficacy of H. Erinaceous extract in Helicobacter pylori activity, 32 chronic gastritis, 33 IBD. 34 Our study showed good outcomes after intake of H.Erinaceous supplements in patients with different gastrointestinal diseases, and the satisfaction of participants was 6 from 10 (18.8%).…”

Section: The Role Of Lion's Mane Mushroom Mane In Cancermentioning

confidence: 56%

Online Survey for Patient Outcomes on Hericium Erinaceous Mushroom

Younis¹

2020

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Hericium Erinaceous (Lion's Mane) mushroom is steadfast becoming one of the most widespread and familiar of medicinal mushrooms currently available worldwide, this could be due to its many surprising health benefits and it is the ability to treat various ailments. In our study, we connected a questionnaire to the largest internet portal for Hericium Erinaceous (H.Erinaceous) consumers to measure respondents' feedback. The questionnaire addresses the attitude and potential benefits of respondents towards H.Erinaceousintake by using a numeric rating scale (NRS),97respondents took part in our study. The most frequently used of H. Erinaceousin our sample were in the treatment of neural diseases, enhance memory and GI disorders. The benefits and satisfied outcomes were highest with participants who use H. Erinaceous in a dose of 2-3 tablets (3g) twice/day to improve memory and cognitive properties and lowest in the treatment of autism even with high doses. 69.9%of participants did not discuss consuming this mushroom with their physician. Objectives for the study to determine the prevalence and purposes of using the mushroom in different diseases and to predict the outcomes, side effects and the most effective dose taken by participants.

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“…A single protein, called HEP3, isolated from H. erinaceus and administered to rats treated with trinitrobenzenesulfonic acid (TNBS) to induce experimental colitis similar to IBD, was capable of restoring the microbiota diversity in treated rats. In particular, treatment with H. erinaceus single protein increased the amounts of Actinobacteria and Tenericutes, reduced those of Bacteroidetes and Firmicutes, and was able to restore a healthy-like ecological structure [128,129]. The effectiveness of HEP3 was also confirmed in other animal models of colitis [130].…”

Section: Microbiota-modulating Fungimentioning

confidence: 92%

“…Also, raw extracts of H. erinaceus were tested in an IBD animal model as whole polysaccharide, alcoholic extract or whole extract. Results indicate that all these formulations were capable of positively modulating the microbiota, but while the polysaccharide extract seems to play a major prebiotic role, the alcoholic extract and whole extract showed major bactericidin-like effects [128,129].…”

Section: Microbiota-modulating Fungimentioning

confidence: 99%

Natural Compounds in the Modulation of the Intestinal Microbiota: Implications in Human Physiology and Pathology

Spisni¹,

Turroni²,

Shahaj³

et al. 2021

Alternative Medicine - Update

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Clinical interest in the human gut microbiota has increased considerably, because of the increasing number of studies linking the human intestinal microbiota and microbiome to an ever increasing number of non-communicable diseases. Many attempts at modulating the gut microbiota have been made using probiotics and prebiotics. However, there are other avenues that are still little explored from a clinical point of view that appear promising to obtain modifications of the microbial ecology and biological activities connected to the microbiome. This chapter summarizes all in vitro, in vivo and clinical studies demonstrating the possibility to positively modulate the intestinal microbiota by using probiotics, foods (and prebiotics), essential oils, fungus and officinal plants. For the future, clinical studies investigating the ability to modify the intestinal microbiota especially by using foods, officinal and aromatic plants or their extracts are required. More knowledge in this field is likely to be of clinical benefit since modulation of the microbiome might support the therapy of most non-communicable diseases in the future.

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Extracts fromHericium erinaceusrelieve inflammatory bowel disease by regulating immunity and gut microbiota

Cited by 69 publications

References 64 publications

Altered Gut Microbiota Composition in Subjects Infected With Clonorchis sinensis

Altered Gut Microbiota Composition in Subjects Infected With Clonorchis sinensis

Online Survey for Patient Outcomes on Hericium Erinaceous Mushroom

Natural Compounds in the Modulation of the Intestinal Microbiota: Implications in Human Physiology and Pathology

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