Extracts of Bolivian plants, Copaifera reticulata and Heisteria pallida inhibit in vitro free radical‐mediated DNA damage

Abstract

The presence of different extracts of antiinflammatory plants Copaifera reticulata and Heisteria pallida in a reaction medium containing calf thymus DNA in a free radical generating system protected DNA against oxidative damage in terms of deoxyribose oxidation. The highest antioxidant activity was obtained using the methanol extract of C. reticulata (IC 50 =3 g/mL), followed by the aqueous extracts of H. pallida (IC 50 = 257 g/ mL) and C. reticulata (IC 50 = 380 g/mL). Both dichloromethane extracts and the methanol extract of H. pallida showed a decreased antioxidant activity at higher concentrations. These results suggest that these extracts are capable of suppressing the in vitro oxidative degradation of DNA.

À propos de I'intérêt médicinal du baume de Copahu

“…Une activit( anti-radicaux libres a ete egalement demontree recemment a partir d'un extrait de c. reticu/ata (Desmarchelier et a/., 1997).…”