Extracts of Cordia gilletii De Wild (Boraginaceae) Quench the Quorum Sensing of Pseudomonas aeruginosa PAO1

Okusa, Philippe N.; Rasamiravaka, Tsiry; Vandeputte, Olivier M.; Stévigny, Caroline; Jaziri, Mondher El; Duez, Pierre

doi:10.5455/jice.20140710031312

Cited by 12 publications

(12 citation statements)

References 28 publications

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“…Moreover, it specifically inhibits the expression of several QS-regulated genes (i.e., lasB, rhlA, lasI, lasR, rhlI, and rhlR) and reduces biofilm formation by PAO1. [ 74 ]…”

Section: P Lant B Y-products Asmentioning

confidence: 99%

Anti-quorum sensing natural compounds

Asfour

2018

J Microsc Ultrastruct

235

109

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Increasing extent of pathogenic resistance to drugs has encouraged the seeking for new anti-virulence drugs. Many pharmacological and pharmacognostical researches are performed to identify new drugs or discover new structures for the development of novel therapeutic agents in the antibiotic treatments. Although many phytochemicals show prominent antimicrobial activity, their power lies in their anti-virulence properties. Quorum sensing (QS) is a bacterial intercellular communication mechanism, which depends on bacterial cell population density and controls the pathogenesis of many organisms by regulating gene expression, including virulence determinants. QS has become an attractive target for the development of novel anti-infective agents that do not rely on the use of antibiotics. Anti-QS compounds are known to have the ability to prohibit bacterial pathogenicity. Medicinal plants offer an attractive repertoire of phytochemicals with novel microbial disease-controlling potential, due to the spectrum of secondary metabolites present in extracts, which include phenolics, quinones, flavonoids, alkaloids, terpenoids, and polyacetylenes. They have recently received considerable attention as a new source of safe and effective QS inhibitory substances. The objective of this review is to give a brief account of the research reports on the plants and natural compounds with anti-QS potential.

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“…Moreover, it specifically inhibits the expression of several QS-regulated genes (i.e., lasB, rhlA, lasI, lasR, rhlI, and rhlR) and reduces biofilm formation by PAO1. [ 74 ]…”

Section: P Lant B Y-products Asmentioning

confidence: 99%

Anti-quorum sensing natural compounds

Asfour

2018

J Microsc Ultrastruct

235

109

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“…A majority of the triterpenoid compounds were identified from leaves and other few from root, stem, seed, fruit and aerial parts. As per structural characteristics, they are classified into four classes: (1) oleanane type isolated from C. alliodora, C. cylindrostachya, C. piauhiensis, C. latifolia and C. multispicata [74][75][76][77][78] ; (2) lupane type identified from C. obliqua and C. gilletii [79][80][81] ; (3) ursane type reported from C. retusa, C. obliqua, C. rothii and C. multispicata [80,[82][83][84][85] ; and (4) dammarane type found in C. spinescens, C. multispicata and C. verbenacea. [86][87][88] [58] C. fragrantissima [59] Heartwood Timber Alliodorol (2) C. alliodora [58] Heartwood Allioquinol C (3) C. alliodora [58] Heartwood Cordiachrome A (4) C. alliodora [58] Heartwood Cordiachrome A (5) C. fragrantissima [59] Timber Cordiachrome B (6) C. fragrantissima [59] Timber Cordiachrome C (7)…”

Section: Triterpenoidsmentioning

confidence: 99%

“…obliqua [117] Root Lupeol-3-rhamnoside C. obliqua [80] Seed Lupeol C. gilletii [81] Roots Betulin C. obliqua [80] Seed Ursane-type triterpenoids a-Amyrin C. retusa [82] Aerial parts b-Amyrin C. obliqua [80] C. rothii [83,84] Seed Fruit 3-Epipomolic acid (50) C. multispicata [85] Leaves Cordiaketal A (51) C. multispicata [85] Leaves Cordiaketal B (52) C. multispicata [85] Leaves Cordianal A (53) C. multispicata [85] Leaves Cordianone (54) C. multispicata [85] Leaves Cordianal B (55) C. multispicata [85] Leaves Cordianal C (56) C. multispicata [85] Leaves Icterogenin (57) C. multispicata [85] Leaves Lantadene A (58) C. multispicata [85] Leaves Lantadene B (59) C. multispicata [85] Leaves Lantic acid (60) C. multispicata [85] Leaves Lantanolic acid (61) C. multispicata [85] Leaves Pomonic acid (62) C. multispicata [85] Leaves Ursomic acid (63) C. multispicata [85] Leaves Dammarane-type triterpenes 3a-Acetoxy-6b, 25-dihydroxy-20(S), 24(S)-epoxydammarane (64) C. spinescens [86] Leaves 3a, 6b, 25-Trihydroxy-20(S), 24(S)-epoxydammarane (65) C. spinescens [86] Leaves Cabraleadiol (66) C. spinescens [86] Leaves Cordialin A (67) C. multispicata [87] Leaves Cordialin B (68) C. verbenacea [88] Leaves Cordianol-A (69) C. multispicata [87] Leaves Cordianol-B (70) C. multispicata [87] Leaves Cordianol-C (71)…”

Section: Terpenoid Quinonementioning

confidence: 99%

“…Carotenoid Lutein C. myxa [104] Leaves Violaxanthin C. myxa [104] Leaves 19 0 -Z-violaxanthin C. myxa [104] Leaves Antheraxanthin C. myxa [104] Leaves a b-Carotene C. myxa [104] Leaves b-Carotene C. myxa [104] Leaves Chlorophyll a C. myxa [104] Leaves Chlorophyll b C. myxa [104] Leaves Chlorophyll b allomer C. myxa [104] Leaves Chlorophyll a allomer C. myxa [104] Leaves Lycopene C. monoica [105] 2.17. Miscellaneous compounds Allantoin C. boissieri [128] C. ecalyculata [150,151] C. obliqua [118] C. trichotoma [62] Root Stem bark Wood Allantoic acid C. ecalyculata [152] Cordicinol (161) C. latifolia [153] Leaves Cordioxime C. platythyrsa [120] Cordixanthone (162) C. platythyrsa [154] Cerebrosides C. platythyrsa [155] Stem bark Ferulaldehyde C. gilletii [81] Roots Benzofuran C. monoica [105] Leaves D-pinitol C. boissieri [128] Root Latifolidin (163) C. latifolia [153] Fruits Latifolinal (164) C. latifolia [153] Fruits Nonacosane C. monoica [105] Leaves Hentriacontanol C. obliqua Hentriacontane C. obliqua C. rothii [83,84] Fruit Hexacosanol C. rothii [121] Leaves Octacosanol C. obliqua C. rothii [93] Leaves existed in the form of glycoside. Compounds 35-40 showed a significant repellent effect against the ant Atta cephalotes.…”

Section: Phenolic Acidsmentioning

confidence: 99%

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Traditional uses, phytochemistry and pharmacology of the medicinal species of the genus Cordia (Boraginaceae)

Oza

Kulkarni

2017

Journal of Pharmacy and Pharmacology

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Objectives Cordia (family Boraginaceae) is a genus of deciduous flowering trees or shrubs comprising more than 300 species distributed widely in the tropical regions. The aim of this review was to provide exhaustive scientific information on traditional uses, phytochemistry and pharmacological activities of the 36 important species with medicinal value from the genus Cordia, to divulge prospects for further research on its therapeutic potential. Key findings Leaves, fruit, bark and seed of a majority of the species were found to possess abundant ethnomedicinal value, but leaves were found to be used most frequently to treat many ailments such as respiratory disorders, stomach pain, wound, inflammation, myalgia, cough, dysentery and diarrhoea. The phytochemical investigation of 36 species resulted in isolation of 293 chemical constituents from various chemical classes. The crude extracts, fractions, essential oils and pure compounds isolated from various Cordia species were reported to have a varied range of pharmacological activities. Summary Many of the traditional uses of the genus Cordia were supported by the results obtained from pharmacological studies performed using various extracts or pure compounds. More attention should be given to the biological evaluation using pure phytochemicals and to identify the mechanism of actions and exploring this genus for new drug discovery.

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“…Pyocyanin secretion, the expression of genes lasB, rhlA, lasI, lasR, rhlI, and rhlR genes and production of biofilm [160] Manilkara zapota Pyocyanin, protease and elastase secretion and production of biofilm [151] Diarylheptanoids from the barks of Alnus viridis and Alnus glutinosa Pyocyanin secretion, twitching motility and production of biofilm [161] Gingerol Exoprotease, rhamnolipid and pyocyanin secretion and biofilm formation [162] Diterpene phytol Pyocyanin secretion, twitching motility and production of biofilm [163] Dovepress antibiotics can reduce the pathogenic factors' expression of P. aeruginosa such as the diminished of exotoxin A secretion, pyocyanin, protease, DNase, and phospholipase C, as well as significantly removing the QS activity of P. aeruginosa. 125 In addition, SICs of tobramycin could block the expressions of rhlI and rhlR genes by decreasing C4-HSL generation.…”

Section: Cordiagilletiimentioning

confidence: 99%

<p>Quorum Quenching: A Potential Target for Antipseudomonal Therapy</p>

Hemmati¹,

Salehi²,

Ghotaslou³

et al. 2020

IDR

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There has been excessive rate of use of antibiotics to fight Pseudomonas aeruginosa (P. aeruginosa) infections worldwide, which has consequently caused the increased resistance to multiple antibiotics in this pathogen. Due to the widespread resistance and the current poor effect of antibiotics consumed to treat P. aeruginosa infections, finding some novel alternative therapeutic methods are necessary for the treatment of infections. The P. aeruginosa biofilms can cause severe infections leading to the increased antibiotic resistance and mortality rate among the patients. In this regard, there are no approaches that can efficiently manage these infections; therefore, novel and effective antimicrobial and antibiofilm agents are needed to control and treat these bacterial infections. Quorum sensing inhibitors (QSIs) or quorum quenchings (QQs) are now considered as potential therapeutic alternatives and/or adjuvants to the current failing antibiotics, which can control the virulence traits of the pathogens, so as a result, the host immune system can quickly eliminate bacteria. Thus, the aims of this review article were presenting a brief explanation of the research reports on the natural and synthetic QSIs of P. aeruginosa, and the assessment of the current understanding on the QS mechanisms and various QQ strategies in P. aeruginosa.

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Extracts of Cordia gilletii De Wild (Boraginaceae) Quench the Quorum Sensing of Pseudomonas aeruginosa PAO1

Cited by 12 publications

References 28 publications

Anti-quorum sensing natural compounds

Anti-quorum sensing natural compounds

Traditional uses, phytochemistry and pharmacology of the medicinal species of the genus Cordia (Boraginaceae)

<p>Quorum Quenching: A Potential Target for Antipseudomonal Therapy</p>

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