Extracts of Feretia apodanthera Del. demonstrated anticonvulsant activities against seizures induced by chemicals and maximal electroshock

Taïwé, Germain Sotoing; Moto, Fleur Clarisse Okomolo; Pale, Simon; Kandeda, Antoine Kavaye; Dawe, Amadou; Kouemou, Nadège; Ayissi, E.R.M.; Ngoupaye, Gwladys Temkou; Njapdounke, Jacqueline Stephanie Kameni; Nkantchoua, G.C.N.; Omam, Jean Pierre Omam; Pahaye, David Bougolla; Bum, Elisabeth Ngo

doi:10.1016/j.eplepsyres.2016.08.009

Cited by 11 publications

(6 citation statements)

References 41 publications

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“…We showed herein that the aqueous extract and alkaloid fraction of stem-bark of F.apodanthera administered at various doses never showed any behavioural abnormality or death of the rat up to a dose of 5000mg/ml and up to 14days of observation. This is consistent with similar result from a previous study [21]. Feretia apodanthera stem-bark may thus be considered safe partly justifying its long term and widespread usage in West African traditional folk medicine.…”

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confidence: 82%

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Cytotoxic and Antibacterial Assessment of Stem-Barks of Feretia apodanthera and Erythrophleum ivorense; Two West African Medicinal and Socio-Economic Trees

Njimoh

Taïwé

Dinga

et al. 2018

IJPPE

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To assess the antibacterial and cytotoxic properties of stem-barks of Feretia apodanthera and Erythrophleum ivorense extracts from powdered stem-barks of Feretia apodanthera and Erythrophleum ivorense were prepared following standard techniques of marceration, filtration and evaporation. Antibacterial activity was assayed against five pathogenic bacteria strains by the well-diffusion and broth microdilution methods. Cytotoxicity was measured by acute toxicity test on female albino rats and confirmed by cell viability assay using 3T3 cell lines. Phytochemical analysis was performed following standard techniques. The aqueous/alkaloid extracts of Feretia apodanthera and the ethanol extract of Erythrophleum ivorense were active against the five pathogenic bacteria strains tested (diameter zone of inhibition (DZI) ranging from 5.1 to 17.8mm). The Feretia apodanthera extracts were the most active against Staphylococcus aureus (DZI 17.1-17.8mm). The MIC and MBC of the extracts of both plants ranged from 0.094mg/ml to 48mg/ml and 0.047mg/ml to 48mg/ml respectively. Extracts of Feretia. apodanthera at 5000mg/Kg had no effect on the behavioural properties of rats and no death was observed. Incubation with 3T3 cell lines did not produce any cell toxicity up to 20mM and 5mM respectively for the aqueous extract and the alkaloid fraction. Incubation with higher concentrations produced cell death with IC50 of 39.41 ± 0.95mM and 38.45 ± 1.64mM respectively. Phytochemical analysis revealed the presence of various constituents. The results show for the first time that stem-bark extracts of F. apodanthera and E. ivorense possess antibacterial activities against common human pathogenic bacteria and the low/lack of toxicity as demonstrated with the F. apodanthera extracts justify and confirm their safe ethnomedical uses.

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supporting

confidence: 82%

“…The methanol extract of leaves of Feretia apodanthera has been shown to exhibit a pronounced antimalarial activity [19]. Its anticonvulsant activity has also been largely documented [20,21] but its effect on pathogenic bacteria has however not been determined.…”

Section: Senegalmentioning

confidence: 99%

Cytotoxic and Antibacterial Assessment of Stem-Barks of Feretia apodanthera and Erythrophleum ivorense; Two West African Medicinal and Socio-Economic Trees

Njimoh

Taïwé

Dinga

et al. 2018

IJPPE

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“…Animals were observed for their behaviour one day following the last pentylenetetrazole administration. The duration time was 30 min for each animal, and seizure severity was scored from 0 to 5 [ 8 , 32 , 33 ].…”

Section: Methodsmentioning

confidence: 99%

“…Briefly, the brain tissue of each mouse was then washed to remove blood, blotted to dry and submerged in 5 mL of methanol, homogenised using a glass Teflon homogeniser for 2 min, and centrifuged at 10,000 rpm at −10°C for 15 min [ 37 ]. Finally, GABA-T activity was quantified in the brain homogenates spectrophotometrically as described previously [ 37 , 38 ] and modified by Taiwe et al [ 32 ].…”

Section: Methodsmentioning

confidence: 99%

Protective Effects of Anthocleista djalonensis Extracts against Pentylenetetrazole-Induced Epileptic Seizures and Neuronal Cell Loss: Role of Antioxidant Defense System

Taïwe

Kouamou

Dabole

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Oxidative stress and neurodegeneration are involved in the initiation of epileptogenesis and progression of epileptic seizures. This study was aimed at investigating the anticonvulsant, antioxidant, and neuroprotective properties of active fractions isolated from Anthocleista djalonensis root barks in pentylenetetrazole mouse models of epileptic seizures. Bioactive-guided fractionation of Anthocleista djalonensis (AFAD) extracts using acute pentylenetetrazole (90 mg/kg) induced generalised tonic-clonic seizures, which afforded a potent anticonvulsant fraction (FPool 5). Further fractionation of AFAD was performed by high-performance liquid chromatography, which yielded fifteen subfractions, which were chemically characterised. In addition, AFAD was tested against convulsions or spontaneous kindled seizures induced, respectively, by acute (50 mg/kg) or subchronic (30 mg/kg) injection of pentylenetetrazole. Finally, oxidative stress markers, brain GABA content, and neuronal cell loss were evaluated in AFAD-treated pentylenetetrazole-kindled mice. Administration of AFAD significantly protected mice against acute pentylenetetrazole (90 mg/kg)-induced convulsions. In acute pentylenetetrazole (50 mg/kg)-induced hippocampal and cortical paroxysmal discharges, AFAD significantly decreased the number of crisis, the cumulative duration of crisis, and the mean duration of crisis. Additionally, AFAD significantly decreased the number of myoclonic jerks and improved the seizure score in subchronic pentylenetetrazole-induced kindled seizures. The pentylenetetrazole-induced alteration of oxidant-antioxidant balance, GABA concentration, and neuronal cells in the brain were attenuated by AFAD treatment. This study showed that AFAD protected mice against pentylenetetrazole-induced epileptic seizures possibly through the enhancement of antioxidant defence and GABAergic signalling. These events might be correlated with the amelioration of neuronal cell loss; hence, AFAD could be a potential candidate for the treatment of epilepsy.

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“…Briefly, the brain tissue of each mouse was washed to remove blood, blotted to dry and submerged in 5 mL of methanol, homogenized using a glass teflon homogenizer for 2 min and centrifuged at 10,000 rpm at -10°C for 15 min [23]. GABA-T activity in the homogenates was measured spectrophotometrically as described previously [23] and with few modified [24]. To a 10 mL volumetric flask, 15 μmol from each of α-oxoglutarate and GABA, 10 μg of pyridoxal phosphate and 1 mL of supernatant of the brain tissue homogenate (10% in sucrose, 0.32 mol/L) were added and the final volume was made up to 3 mL with buffer containing 0.2 M Tris-HCl (pH 8.6).…”

Section: Determination Of Brain Gaba Concentration and Gaba-transaminase Activitymentioning

confidence: 99%

Anxiolytic and antipyretic properties of the root aqueous extract of Bombax costatum Pellegr. et Vuillet. (Bombacaceae) in mice: Implication of behavioural and neurochemical approaches

Wanbara

Taïwé

Njapdounke

et al. 2021

GSC Biol. and Pharm. Sci.

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Ethnopharmacological relevance: Bombax costatum Pellegr. et Vuillet. (Bombacaceaea) is a plant used in traditional medicine in Cameroon to treat memory impairment, anxiety, insomnia and agitation. Aim of the study: The aqueous extract of Bombax costatum is evaluated for its anxiolytic like effect in mice using experimental models. Materials and methods: The plant extract is administered orally to mice. They were tested one hour later in the stress-induced hyperthermia, hole board, and open field or elevated plus maze tests, respectively. Finally, the brain Gamma aminobutyric acid [GABA] content and GABA-T were quantified in Bombax costatum aqueous extract-treated mice at the end of elevated plus maze test. Results: Bombax costatum aqueous extract showed anxiolytic activity. In stress-induced hyperthermia test, the plant extract significantly antagonised the increase of temperature. There is a significant reduction in the stress-induced hyperthermia from 1.13 ± 0.06℃ in the negative control group treated with distilled water to 0.26 ± 0.02℃ in the group of mice administered 100 mg/kg aqueous extract. In addition, Bombax costatum showed antipyretic activity by reducing the body temperature. In the elevated plus maze test, the aqueous extract increased the number of entries into, percentage of entries into, and percentage of time in open arms. It also reduced the percentage of entries and time in closed arms. Conclusion: The obtained results suggested that Bombax costatum aqueous extracts possess anxiolytic-like and antipyretic activities in mice. This plant could be helpful in the treatment of anxiety and fever in traditional medicine in Cameroon.

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Extracts of Feretia apodanthera Del. demonstrated anticonvulsant activities against seizures induced by chemicals and maximal electroshock

Cited by 11 publications

References 41 publications

Cytotoxic and Antibacterial Assessment of Stem-Barks of <i>Feretia apodanthera</i> and <i>Erythrophleum ivorense</i>; Two West African Medicinal and Socio-Economic Trees

Cytotoxic and Antibacterial Assessment of Stem-Barks of <i>Feretia apodanthera</i> and <i>Erythrophleum ivorense</i>; Two West African Medicinal and Socio-Economic Trees

Protective Effects of Anthocleista djalonensis Extracts against Pentylenetetrazole-Induced Epileptic Seizures and Neuronal Cell Loss: Role of Antioxidant Defense System

Anxiolytic and antipyretic properties of the root aqueous extract of Bombax costatum Pellegr. et Vuillet. (Bombacaceae) in mice: Implication of behavioural and neurochemical approaches

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