Extracts of ginkgo biloba leaves inhibit monoamine oxidase

White, Helen L.; Scates, Philip W.; Cooper, Barrett R.

doi:10.1016/0024-3205(96)00097-5

Cited by 99 publications

(56 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The decreased density of b-adrenoreceptors shown in this study might be due to down-regulation of receptors following an increase of biogenic monoamines and especially of noradrenaline. This suggestion is consistent with a blockade of monoamine neurotransmitter degradation due to inhibition of monoamine oxidase caused by Ginkgo biloba extracts (White et al 1996).…”

Section: Resultssupporting

confidence: 56%

Effect of Ginkgo biloba extract on β‐adrenergic receptors in different rat brain regions

Hadjiivanova

Petkov

2002

Phytotherapy Research

View full text Add to dashboard Cite

The effect of oral administration of Ginkgo biloba extract at a dose of 90 mg/kg for 7 consecutive days on rat brain beta-adrenergic receptors in the frontal cortex, hippocampus, striatum and hypothalamus was studied. Ginkgo biloba treatment induced a significant decrease in the density (B(max)) of beta-adrenoreceptors in the frontal cortex and hippocampus. It has been suggested that modulation of the beta-adrenergic system is implicated in the favourable effects of Ginkgo biloba extracts on learning and memory.

show abstract

Section: Resultssupporting

confidence: 56%

Effect of Ginkgo biloba extract on β‐adrenergic receptors in different rat brain regions

Hadjiivanova

Petkov

2002

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…109 One in vitro study reported that compounds present in both dried and fresh Ginkgo leaves have monoamine oxidase (MAO) (both A and B) inhibitory activity 110 ; however, there is currently no evidence that G biloba extracts ingested in normal dosages by humans will inhibit MAO activity in the brain. Finally, there is evidence from animal studies that ginkolide B may have a neuroprotective effect in brain injury.…”

Section: Ginkgomentioning

confidence: 99%

Herbal Remedies in Psychiatric Practice

Wong¹,

Smith²,

Boon³

1998

Arch Gen Psychiatry

198

123

View full text Add to dashboard Cite

Patients' use of alternative and complementary health services has created a need for physicians to become informed about the current literature regarding these treatments. Herbal remedies may be encountered in psychiatric practice when they are used to treat psychiatric symptoms; produce changes in mood, thinking, or behavior as a side effect; or interact with psychiatric medications. English-language articles and translated abstracts or articles (where available) found on MEDLINE and sources from the alternative/complementary health field were reviewed. Each herb was assessed for its safety, side effects, drug interactions, and efficacy in treating target symptoms or diagnoses. A synopsis of the information available for each herb is presented. In many cases the quantity and quality of data were insufficient to make definitive conclusions about efficacy or safety. However, there was good evidence for the efficacy of St John's wort for the treatment of depression and for ginkgo in the treatment of memory impairment caused by dementia. More research is required for most of the herbs reviewed, but the information published to date is still of clinical interest in diagnosing, counseling, and treating patients who may be taking botanical remedies.

show abstract

“…Ginkgo biloba has been shown to have neuroprotective effects on brain neurons against oxidative stress induced by peroxidation in some recent studies (Maitra et al, 1995;Oyama et al, 1996;Ni et al, 1996;Hoyer et al, 1999). More recent evidence has shown that Ginkgo biloba also acts as an inhibitor of the monoamine metabolizing enzymes, monoamine oxidase A and B, which may also contribute to its free-radical scavenging and neuroprotective effects (White et al, 1996). In addition, evidence suggests that both acute and chronic doses of Ginkgo biloba may modulate the cholinergic system (Nathan, 2000), with direct effects on choline uptake and acetylcholine release (Kristofikova and Klaschka, 1997) and increases in cholinergic muscarinic receptors (Taylor, 1986).…”

Section: Introductionmentioning

confidence: 95%

Effects of a combined extract of Ginkgo biloba and Bacopa monniera on cognitive function in healthy humans

Nathan

Tanner

Lloyd

et al. 2004

Human Psychopharmacology

View full text Add to dashboard Cite

Extracts of Ginkgo biloba and Bacopa monniera have been shown to produce positive effects on cognitive function in healthy subjects. While the exact mechanisms are not known, it has been suggested that antioxidant properties and cholinergic modulation may play a role. In the current study the sub-chronic (2 weeks) and chronic (4 weeks) effects of an extract containing Ginkgo biloba (120 mg) and Bacopa monniera (300 mg) (Blackmores Ginkgo Brahmi) on cognitive function were examined. The study was a randomized, double-blind, placebo-controlled, independent group design in which 85 healthy subjects were allocated to one of two treatment conditions (placebo or combined Ginkgo biloba and Bacopa monniera extract). Testing was conducted at baseline and 2 and 4 weeks post treatment. The results showed that the combined extract relative to placebo did not demonstrate any significant effects on tests investigating a range of cognitive processes including attention, short-term and working memory, verbal learning, memory consolidation, executive processes, planning and problem solving, information processing speed, motor responsiveness and decision making. These findings suggest that at least within the current treatment duration and doses, an extract containing Ginkgo biloba and Bacopa monniera had no cognitive enhancing effects in healthy subjects.

show abstract

Extracts of ginkgo biloba leaves inhibit monoamine oxidase

Cited by 99 publications

References 9 publications

Effect of Ginkgo biloba extract on β‐adrenergic receptors in different rat brain regions

Effect of Ginkgo biloba extract on β‐adrenergic receptors in different rat brain regions

Herbal Remedies in Psychiatric Practice

Effects of a combined extract of Ginkgo biloba and Bacopa monniera on cognitive function in healthy humans

Contact Info

Product

Resources

About