Extracts of selected Lamiaceae species as promising antidiabetics: Chemical profiling, in vitro and in silico approach combined with dynamical modeling

Enzyme Inhibition and Antioxidant Activities of Asparagus officinalis L. and Analysis of Its Phytochemical Content by LC/MS/MS

“…In another study, rutin was found to have a more substantial inhibitory effect than acarbose, with an IC 50 value of 188.07 μg/mL [43] . In the study conducted by Pavlović et al., it was stated that O. basilicum extracts, including rutin, p‐ hydroxybenzoic, and p‐ Coumaric acid, showed a strong inhibitory effect on the enzyme [45] . It has been stated that consumption of α‐glucosidase inhibitors, one of the target enzymes in the treatment of T2DM, through components in the daily diet, maybe a preferred treatment method due to its minimal side effects, unlike traditional treatments with drugs such as acarbose [46] .…”

“…[43] In the study conducted by Pavlović et al, it was stated that O. basilicum extracts, including rutin, phydroxybenzoic, and p-Coumaric acid, showed a strong inhibitory effect on the enzyme. [45] It has been stated that consumption of α-glucosidase inhibitors, one of the target enzymes in the treatment of T2DM, through components in the daily diet, maybe a preferred treatment method due to its minimal side effects, unlike traditional treatments with drugs such as acarbose. [46] Therefore, based on the findings obtained as a result of the study, it can be said that the inclusion of products obtained from Asparagus officinalis L. extracts in the diet may potentially be used in the prevention and treatment of T2DM.…”

Natural Sweetener, Glycyrrhetinic Acid 3-O-Mono-beta-d-glucuronide, for Postprandial Hyperglycemia Management

“…The crystal structure of human lysosomal α-glucosidase (PDB code: 5KZX) is usually used to perform the docking study , and was used in this study. The 3D homology model of α-glucosidase was constructed with a resolution of 2.0 Å (PDB code: 5KZX).…”

The chemical profiling and assessment of antioxidative, antidiabetic and antineurodegenerative potential of Kombucha fermented Camellia sinensis, Coffea arabica and Ganoderma lucidum extracts

“…13–15 Many studies have shown that plants and mushrooms possess bioactive compounds with antitumor, antidiabetic, antineurodegenerative, anti-inflammatory, antimicrobial, antiviral and other medicinal properties. 5,16,17…”

“…[13][14][15] Many studies have shown that plants and mushrooms possess bioactive compounds with antitumor, antidiabetic, antineurodegenerative, anti-inflammatory, antimicrobial, antiviral and other medicinal properties. 5,16,17 Kombucha, also known as the Manchurian mushroom, represents a symbiotic culture of bacteria and yeasts. 18 Kombucha tea is a slightly sour and sweet, carbonated refreshing beverage obtained by the fermentation of sweetened green or black tea leaves with a symbiotic association of fungi and acetic acid bacteria (most often fungi from the following genera: Schizosaccharomyces, Zygosaccharomyces, Candida, Torulospora, Pichia, Mycotorula, and Mycoderma, and bacteria: Acetobacter and Gluconobacter).…”