2016
DOI: 10.1038/srep20999
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Extraembryonic but not embryonic SUMO-specific protease 2 is required for heart development

Abstract: SUMO-specific protease 2 (SENP2) activities to remove SUMO from its substrates is essential for development of trophoblast stem cells, niches and lineages. Global deletion of SENP2 leads to midgestation lethality, and causes severe defects in the placenta which is accompanied by embryonic brain and heart abnormalities. Because of the placental deficiencies, the role of SENP2 in development of the embryonic tissues has not been properly determined. The brain and heart abnormalities may be secondary to placental… Show more

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Cited by 32 publications
(36 citation statements)
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“…Disruption of gene function in placental trophoblast cells can indeed exert downstream defects in cardiovascular or hematopoietic development in mice. 3841 Likewise, abnormal placental development has been correlated with subsequent cardiovascular disease in humans (reviewed in Burton et al 42 ). The current animal models provide an experimentally accessible opportunity for testing the hypothesis that the phenotypic penetrance of spontaneous, overt thrombosis in adult Thbd-deficient mice is in part governed by placental abnormalities caused by the absence of Thbd from trophoblast cells.…”
Section: Discussionmentioning
confidence: 99%
“…Disruption of gene function in placental trophoblast cells can indeed exert downstream defects in cardiovascular or hematopoietic development in mice. 3841 Likewise, abnormal placental development has been correlated with subsequent cardiovascular disease in humans (reviewed in Burton et al 42 ). The current animal models provide an experimentally accessible opportunity for testing the hypothesis that the phenotypic penetrance of spontaneous, overt thrombosis in adult Thbd-deficient mice is in part governed by placental abnormalities caused by the absence of Thbd from trophoblast cells.…”
Section: Discussionmentioning
confidence: 99%
“…Skeletal preparation, fixation, and embedding for paraffin and frozen sections were performed as described . Samples were subject to hematoxylin/eosin staining for histology, Alcian blue staining, von Kossa staining, and immunological staining with avidin:biotinylated enzyme complex as described . To quantify the intensify of Alcian blue staining, cells were fixed in solution containing 30% ethanol, 0.4% paraformaldehyde, and 4% acetic acid for 15 min at room temperature, followed by incubation with 0.05% Alcian blue staining solution in 75% ethanol: 0.1 M hydrochloride (4:1) overnight at 37°C.…”
Section: Methodsmentioning
confidence: 99%
“…14 The heart deformities associated with global inactivation of SENP2 are not primary but secondary defects due to placental insufficiency. However, our data show a tight link of heart deformities to placental deficiencies, suggesting these are dependent events.…”
Section: Discussionmentioning
confidence: 99%
“…12,13 The placental insufficiency greatly complicates the analysis of these phenotypes as they arise at specific stages when embryogenesis becomes highly dependent on placental function. 12,14 With a healthy placenta containing intact SENP2, embryos with epiblast-specific ablation of SENP2 did not exhibit any brain and heart defects, demonstrating the contribution of placental insufficiency to the observed embryonic deformities. 12,14 With a healthy placenta containing intact SENP2, embryos with epiblast-specific ablation of SENP2 did not exhibit any brain and heart defects, demonstrating the contribution of placental insufficiency to the observed embryonic deformities.…”
Section: Introductionmentioning
confidence: 94%
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