Extraesophageal Reflux in Patients with Contact Granuloma: A Prospective           Controlled Study

Ylitalo, Riitta; Ramel, Stig

doi:10.1177/000348940211100509

Cited by 74 publications

(66 citation statements)

References 20 publications

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“…On the basis of these results, pharyngeal reflux was thought to be a rare event in normal individuals [15]. Several studies performed since the Koufman report have documented pharyngeal acid exposure in subjects known to be without physical findings or symptoms suggestive of LPR [16][17][18][19][20][21][22][23][24][25][26]. These findings are well recognized and support the existence of a physiologic range of pharyngeal reflux.…”

Section: Historical Perspectivesmentioning

confidence: 88%

“…Demographic information concerning controls was unavailable. Finally, two studies by Ylitalo et al [23,24] evaluated comparative data from patients with either contact granuloma or posterior laryngitis and normal controls. Control subjects from these studies ranged in age from 20 to 51 years, were asymptomatic for LPR or GER, and were endoscopically negative for reflux findings in the larynx.…”

Section: Current Criteriamentioning

confidence: 99%

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Laryngopharyngeal Reflux: Trends in Diagnostic Interpretation Criteria

et al. 2004

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Laryngopharyngeal reflux (LPR) is becoming recognized as a clinical entity with a variety of presentations distinct from those of gastroesophreflux disease (GERD). However, much uncertainty remains as to what is considered pathologic versus physiologic reflux. The aim of the study was to determine the normal range of pharyngeal reflux (PR) occurring in healthy adults based on pH-monitoring parameters utilized in the DeMeester scoring system for GERD. We have reviewed the current pool of prospective literature examining ambulatory dual-channel pH-monitoring study data derived from hypopharyngeal proximal probes in normal adults. From our review we have identified trends in several monitoring parameters based on the DeMeester scoring system for GERD. Our discussion recognizes and accepts the limitations imposed by small sample sizes and the number of healthy individuals that would be required to determine the general adult physiologic range of PR. We also explore the possible need for separate normal PR reference intervals based on age or gender disparities. Additional discussion and the summary address future directions for LPR research notably, (1) identification of the most appropriate research paradigm for LPR (i.e., pH 4 vs. 5), (2) establishing reproducibility for the appropriate LPR research paradigm, and (3) complementary modalities to ambulatory dual-channel pH monitoring for the study of acid and nonacid bolus movement within the esophagus

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Section: Historical Perspectivesmentioning

confidence: 88%

Section: Current Criteriamentioning

confidence: 99%

Laryngopharyngeal Reflux: Trends in Diagnostic Interpretation Criteria

et al. 2004

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“…Acid exposure of the pharynx is prevalent in cases of granuloma. According to Ylitalo (2002), acid reflux on the pharynx (detected by 24-hour pH meter) occurred in 17 out of 26 cases with granuloma (1 to 20 episodes per patient) and in 5 out of 19 controls (1 to 8 episodes per person). The duration of reflux is short and predominant in the standing position.…”

Section: Discussionmentioning

confidence: 99%

Granuloma de processo vocal: caracterização clínica, tratamento e evolução

Lemos¹,

Sennes

Imamura

et al. 2005

Rev. Bras. Otorrinolaringol.

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Vocal process granuloma is a disease whose etiopathogenesis is not well defined. Therefore, its clinical and surgical treatment is not standardized and its therapeutic results depend on the hospital where it is seen. Aim: Aiming to characterize patients with vocal process granuloma treated in our hospital, the therapeutic approach used and clinical evolution. Material and method: We performed a retrospective review of records. Results: We found more male vocal process granuloma, except when associated with laryngeal intubation. The most frequent related etiopathogenic factor was laryngeal-pharynx reflux, followed by laryngeal intubation and vocal abuse. Clinical management with proton-pump inhibitor (PPI), topical inhalant steroid and phonotherapy was enough for remission on 48.6% of the patients. Surgery for removal of the granuloma associated with clinical management was effective in 90% of the events. Later recurrences (more than one year) were noticed in five patients, suggesting that associated etiopathogenic factors should be held for a long time.

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“…La presencia de granulomas también ha sido asociado de forma importante. (65%-74%) en los casos confirmados de RFL, mediante la monitorización de pH 15 . El llamado "surco vocal" corresponde a un pseudo sulcus, frecuentemente ubicada en la zona intermedia del pliegue vocal.…”

Section: Laringoscopíaunclassified

Reflujo faringolaríngeo: Revisión bibliográfica

O²,

P³

et al. 2008

Rev. Otorrinolaringol. Cir. Cabeza Cuello

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. RESUMENEl reflujo faringolaríngeo (RFL) es un síndrome que se asocia a una constelación de síntomas. Entre ellos los más frecuentemente descritos son la disfonía, la fatiga vocal, el globus faríngeo, la tos crónica y la carraspera.Se realizó una búsqueda exhaustiva en bases de datos internacionales y nacionales en relación a RFL. Se utilizaron palabras clave como globus, carraspera, laringitis, disfonía y reflujo gastroesofágico. Se obtuvieron alrededor de 35 referencias en relación al tema estudiado, siendo la mayoría publicadas con posterioridad al año 2000.En relación a su etiología, se cree que el flujo retrógrado de contenido gástrico hacia la faringe sería el hecho más importante para su génesis, pero recientemente se ha demostrado que si bien este hecho patológico es fundamental en la producción de los síntomas, existen factores adicionales, capaces de perpetuarlo, permitiendo considerar al RFL como una entidad diferente del reflujo gastroesofágico (RGE).Palabras clave: Reflujo faringolaríngeo, reflujo gastroesofágico. ABSTRACTPharyngolaryngeal reflux (RFL) is a syndrome associated to a variety of symptoms. Among them, the most frequently described are dysphonia, vocal fatigue, pharyngeal globus, chronic coughing and throat clearing.An exhaustive search of international and national databases was performed. Globus, throat clearing, laryngitis and gastroesophageal reflux were used as keywords. Some 35 search-related references were retrieved, of which most were published from 2000 to date. Respect to the etiology of pharyngolaryngeal reflux, the current view is that gastric content reflux to the pharynx is the most important factor, but recently it has been demonstrated that, although this pathological trait is pivotal for symptoms appearance, there are additional factors that could perpetuate the symptoms in time, which contribute to consider RFL as a different entity from gastroesophageal reflux (RGE).

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Extraesophageal Reflux in Patients with Contact Granuloma: A Prospective Controlled Study

Cited by 74 publications

References 20 publications

Laryngopharyngeal Reflux: Trends in Diagnostic Interpretation Criteria

Laryngopharyngeal Reflux: Trends in Diagnostic Interpretation Criteria

Granuloma de processo vocal: caracterização clínica, tratamento e evolução

Reflujo faringolaríngeo: Revisión bibliográfica

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