Extragastric Manifestations of Helicobacter pylori Infection – Other Helicobacter Species

Solnick, Jay V.; Franceschi, Francesco; Roccarina, Davide; Gasbarrini, Antonio

doi:10.1111/j.1478-405x.2006.00430.x

Cited by 23 publications

(19 citation statements)

References 72 publications

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“…Selenium, as in the form of selenocysteine, is involved in glutathione peroxidase, iodothyronine de-iodinase, and thioredoxin reductase enzymes [7]. Several studies have shown that H. pylori infection has relations to the deficiencies in copper, vitamin B12, folic acid, and vitamin A, C, and E [5,[8][9][10][11]. These deficiencies may be derived from anorexia caused by dyspeptic symptoms or from malabsorbtion secondary to intestinal bacterial infections, which is the result of hypo-achlorhydria in the stomach in the presence of H. pylori.…”

Section: Introductionmentioning

confidence: 99%

Serum Zinc, Copper, Magnesium and Selenium Levels in Children with Helicobacter Pylori Infection

et al. 2015

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Objective: Helicobacter pylori infection can cause disease from mild to severe that may be accompanied by micronutrient deficiencies. We aimed to investigate serum zinc, copper, magnesium and selenium levels in Helicobacter pylori positive children. Materials and Methods:Thirty-four children, with chronic abdominal pain and diag-nosed to be Helicobacter pylori-positive and 20 healthy children with the same demo-graphic characteristics were included in the study. Serum zinc, copper and magnesium levels were measured in the flame unit of atomic absorption spectrophotometer, selenium levels were measured in the graphite unit of the same atomic absorption spectrophotometer.Results: Serum zinc levels were significantly higher and serum magnesium levels were significantly lower (p<0.05) in Helicobacter pylori positive children than those of the control group. Although copper levels were lower in patient group than in control group, this difference was not statistically significant (p>0.05). There was no significant difference between serum selenium levels of two groups. Conclusion:We concluded that in Helicobacter pylori-positive children, many trace elements and mineral metabolism may change. Keywords:Helicobacter Pylori, zinc, copper, magnesium, selenium Özet Amaç: Helicobacter pylori enfeksiyonu mikro besin eksikliklerinin eşlik ettiği hafif şiddetten ağır tablolara kadar değişebilen hastalıklara sebep olabilir. Biz bu çalışmada Helicobacter pylori pozitif çocuklarda serum çin-ko, bakır, magnezyum ve selenyum düzeylerini araştırılmayı amaçladık. Gereç ve Yöntem:Kronik karın ağrısı olan ve Helicobacter pylori pozitifliği saptanan otuz dört hasta çocuk ve hasta grubu ile aynı demografik özelliklere sahip sağlıklı 20 çocuk çalışmaya dahil edildi. Serum çinko, bakır ve magnezyum düzeyleri atomik absorpsiyon spektrofotometresi alev ünitesinde, serum selenyum seviyeleri ise aynı spektrofotometrenin grafit fırın ünitesinde ölçüldü. Bulgular:Çalışmamız sonucunda Helicobacter pylori pozitifliği saptanan çocuklarda kontrol grubuna göre serum çinko düzeylerini istatistiksel olarak anlamlı de-recede yüksek, Magnezyum düzeylerini ise düşük bulduk (p<0,05). Bakır düzeyleri kontrol grubunda daha yüksek olmasına rağmen istatistiksel olarak anlamlı değildi (p>0,05). Serum selenyum düzeyleri açısından her iki grup arasında istatistiksel anlamlı bir farklılık yoktu. Sonuç:Helicobacter pylori pozitif çocuklarda, birçok eser element ve mineral metabolizmasında değişiklikler olabileceğini söyleyebiliriz.

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Section: Introductionmentioning

confidence: 99%

Serum Zinc, Copper, Magnesium and Selenium Levels in Children with Helicobacter Pylori Infection

et al. 2015

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“…In this respect, Hp -I is strongly associated with idiopathic thrombocytopenic purpura [29], and long-term platelet responses to Hp eradication have been reported in Canadian patients with idiopathic thrombocytopenic purpura [30]. Hp urease B antibody could cross-react with human platelet glycoprotein IIIa and partly inhibit platelet aggregation [31].…”

Section: Discussionmentioning

confidence: 99%

High Prevalence of Helicobacter pylori Infection in Greek Patients with Myelodysplastic Syndromes

Diamantidis

Ioannidou-Papagiannaki²,

Kountouras³

et al. 2010

Acta Haematol

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Background/Aims/Methods: To determine the frequency of Helicobacter pylori infection (Hp-I) in 73 patients with myelodysplastic syndromes (MDS) and 40 controls, serologic analyses of Hp and ¹³C-urease breath tests (INFAI) were performed. Gastric mucosal biopsy specimens were obtained to determine the presence of Hp-I using a rapid urease test, i.e. the Campylobacter-like organism (CLO) test, and cresyl violet staining. Peripheral blood (PB) flow cytometry for CD3, CD4, CD8, CD14, CD19 and CD34 was conducted in 35 patients and in controls. Results:Hp-I was detected by: (a) serology in 75.34% of patients (p = 0.000), (b) INFAI in 57.69% of patients, (c) CLO in 60.71% of patients and (d) histological confirmation in 80.36% of patients (p = 0.001). No correlation between Hp-I and CD3, CD4, CD8, CD14, CD19 expression, leukemic transformation or death was observed. However, in 20 cases, significant variation in the PB lymphocytic proportion possibly attributable to Hp-I was ascertained, in contrast to the expected MDS ratio. Conclusion: Although there is no evidence for a causal relationship between Hp-I and MDS, the increased prevalence of Hp-I among the MDS patients is an interesting finding that deserves further investigation as it may indicate a common factor causing susceptibilities to both MDS and Hp-I or that Hp might influence the pathophysiology of MDS.

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“…Besides gastric disorders, the Hp etiology is discussed in connection with the development of different extra-gastric diseases such as vascular, skin and autoimmune diseases such as autoimmune thyroiditis (De Koster et al 2000;Solnic et al 2006). In several studies, increased prevalence of Hp infection in patients with AT was observed and confirmed not only by higher anti-Hp IgG levels but also positive urea breath tests (De Luis et al 1998).…”

Section: Abbreviations Hpmentioning

confidence: 99%

Lymphocyte proliferative response to Helicobacter pylori antigens in H. pylori-infected patients

Hrdá

Potuźníková

et al. 2010

Folia Microbiol

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Helicobacter pylori (Hp) contributes to the development of gastric and extra-gastric diseases such as autoimmune thyroiditis (AT), and causes persistent life-long infection despite local and systemic immune response. We determined the specific cellular immune response to Hp antigens and PWM (control mitogen) in two groups of Hp infected patients--group A (n = 21), involving patients with autoimmune thyroiditis and group B (n = 13) of patients without AT--using modified lymphocyte transformation test before and after eradication therapy in comparison with healthy controls (group C, n = 15). Immune reactivity to the majority of Hp antigens (aHp, hHp, HpAg, CagA) was significantly lower in group B before eradication therapy in comparison with healthy Hp negative controls. A significant increase in immune reactivity was observed in group B to certain Hp antigens after successful eradication. The same levels (but insignificant) of immune reactivity were shown in group A. Our results indicate that Hp can cause the inhibition of the specific cellular immune response in Hp infected patients with or without autoimmune diseases such as AT, which can be abrogated by successful eradication of Hp. Lymphocyte transformation test appears to be a good tool for detection of immune memory cellular response in patients with Hp infection.

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Extragastric Manifestations of Helicobacter pylori Infection – Other Helicobacter Species

Cited by 23 publications

References 72 publications

Serum Zinc, Copper, Magnesium and Selenium Levels in Children with Helicobacter Pylori Infection

Serum Zinc, Copper, Magnesium and Selenium Levels in Children with Helicobacter Pylori Infection

High Prevalence of <i>Helicobacter pylori</i> Infection in Greek Patients with Myelodysplastic Syndromes

Lymphocyte proliferative response to Helicobacter pylori antigens in H. pylori-infected patients

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