Extrahepatic cholestasis in the dog and the differentiation of extrahepatic and intrahepatic cholestasis

Ingh, T. S. G. A. M. van den; Rothuizen, J.; Brom, W. E. van den

doi:10.1080/01652176.1986.9694034

Cited by 11 publications

(5 citation statements)

References 9 publications

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“…Because the bile duct passes through the pancreas on the way to the duodenum, CP is a reported cause of post‐hepatic biliary obstruction in dogs, but the long‐term hepatic sequelae have not been investigated (Head and Daniel 2005, Mayhew and others 2006). The relative importance of CP as a cause of extra‐hepatic cholestasis is also a matter of debate, because a previous report did not find CP in any of 19 dogs with extra‐hepatic biliary obstruction (Van den Ingh and others 1986).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of hepatic lesions at post‐mortem examination in dogs and association with pancreatitis

Watson

Roulois

Scase

et al. 2010

J of Small Animal Practice

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Objectives: To assess the prevalence of canine chronic hepatitis (CH) and other liver diseases in first opinion practice and identify associations with concurrent chronic pancreatitis (CP). Methods: One large section of left lateral lobe of liver was taken from 200 unselected canine post‐mortem examinations from first opinion practices. Histological changes were categorised based on WSAVA criteria. Prevalence of CH and other liver diseases were calculated. Relative risks (RR) for liver histopathology in association with CP and for CH in different breeds were also calculated. Results: The prevalence of CH was 12%. Some breeds had an increased RR of CH, although sample sizes were small. Dogs with CP had an increased RR of reactive hepatitis but no significant association with the other liver diseases. Clinical Significance: CH is common in the first opinion dog population but less common than CP. CP was significantly associated with reactive hepatitis but not CH. Possible breed associations mirrored another recent UK study. Some dogs with CP may be erroneously diagnosed clinically as having CH on the basis of increased serum liver enzymes because of concurrent reactive hepatitis if the diagnosis is not confirmed histologically.

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Section: Introductionmentioning

confidence: 99%

Prevalence of hepatic lesions at post‐mortem examination in dogs and association with pancreatitis

Watson

Roulois

Scase

et al. 2010

J of Small Animal Practice

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“…19 Dog. Chronic extrahepatic cholestasis with periductal concentric fibrosis and a mixed inflammatory infiltrate.…”

mentioning

confidence: 99%

Morphological classification of biliary disorders of the canine and feline liver

Ingh¹,

Cullen²,

Twedt³

et al. 2006

WSAVA Standards for Clinical and Histological Diagnosis of Canine and Feline Liver Diseases

110

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“…The clinical and laboratory data in these 7 dogs were suggestive of acute extrahepatic cholestasis (14). Histologically, a combination of severe hepatocanalicular cholestasis, portal inflammation and absence of bile ducts in the smaller portal areas was striking.…”

Section: Discussionmentioning

confidence: 84%

“…Histologically, a combination of severe hepatocanalicular cholestasis, portal inflammation and absence of bile ducts in the smaller portal areas was striking. These portal changes are inconsistent with extrahepatic cholestasis, as in acute extrahepatic cholestasis the portal areas are oedematous with intact bile ducts, even often dilated, and a neutrophilic portal infiltrate, and in chronic extrahepatic cholestasis the portal areas show bile duct proliferation, fibrosis and a mixed portal infiltrate (14). Moreover, laparoscopy, laparotomy and/or post-mortem examination showed normal patent extrahepatic bile ducts.…”

Section: Discussionmentioning

confidence: 97%

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Destructive cholangiolitis in seven dogs

Ingh

Rothuizen

Bergman³

1988

Veterinary Quarterly

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SUMMARY In seven dogs presented with clinical signs and laboratory data suggestive of extrahepatic cholestasis, destructive cholangiolitis was diagnosed. The diagnosis was based on the absence of extrahepatic cholestasis at laparoscopy, laparotomy and/or post-mortem examination, and the presence of specific liver lesions i.e. loss of bile ducts in the smaller portal areas. The disease is compared with drug-induced (chlorpromazine) cholestasis in man. In two dogs clinical signs were preceded by longstanding respectively repeated sulphonamide medication.

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Extrahepatic cholestasis in the dog and the differentiation of extrahepatic and intrahepatic cholestasis

Cited by 11 publications

References 9 publications

Prevalence of hepatic lesions at post‐mortem examination in dogs and association with pancreatitis

Prevalence of hepatic lesions at post‐mortem examination in dogs and association with pancreatitis

Morphological classification of biliary disorders of the canine and feline liver

Destructive cholangiolitis in seven dogs

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