Extrahepatic Manifestations in Alcoholic Liver Disease

Nath, Preetam; Anand, Anil C.

doi:10.1016/j.jceh.2022.02.004

Cited by 7 publications

(3 citation statements)

References 143 publications

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“…The occurrence of cardiomyopathy in patients with ALC undoubtedly increases the risk of mortality. Therefore, a clear understanding of the prevalence and characteristics of alcoholic cardiomyopathy in ALC patients is of crucial importance [10][11][12].…”

Section: Discussionmentioning

confidence: 99%

Alcoholic cardiomyopathy in patients with alcoholic liver cirrhosis: a study across 10 years

Wang

Gao

Liu

et al. 2023

European Journal of Gastroenterology &Amp; Hepatology

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Background and objectives Available data regarding cardiomyopathy in patients with alcoholic liver cirrhosis (ALC) are very limited because it often requires multidisciplinary assessments. The study aims to evaluate the prevalence of alcoholic cardiomyopathy in ALC and their clinical correlations. Methods Adult ALC patients without a previous diagnosis of cardiovascular diseases between January 2010 and December 2019 were included in the study. The prevalence rate of alcoholic cardiomyopathy in patients with ALC was calculated together with a 95% confidence interval (CI) using the Clopper–Pearson exact method. Results A total of 1022 ALC patients were included. Male patients predominated (90.5%). ECG abnormalities were observed in 353 patients (34.5%). Prolonged QT interval was most common in ALC patients with ECG abnormalities, which occurred in 109. Thirty-five ALC patients underwent the cardiac MRI examination and only one patient was found with cardiomyopathy. The estimated prevalence rate of alcoholic cardiomyopathy in all the ALC patients was 0.0286 (95% CI, 0.0007–0.1492). There was no statistical difference regarding the prevalence rate between the group of patients with ECG abnormalities and the group without ECG abnormalities (0.0400 vs. 0.0000, P = 1.000). Conclusion Although ECG abnormalities, especially QT prolongation, existed in a proportion of ALC patients, cardiomyopathy in the patient population was not common. Further larger-sample studies based on cardiac MRI are needed to verify our results.

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Section: Discussionmentioning

confidence: 99%

Alcoholic cardiomyopathy in patients with alcoholic liver cirrhosis: a study across 10 years

Wang

Gao

Liu

et al. 2023

European Journal of Gastroenterology &Amp; Hepatology

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“…The thrombocytopenia was probably related to alcohol intake, as mild thrombocytopenia is common in individuals with excess alcohol intake. 2 Physical examination revealed a Mallampati score of 4 and limited neck movement. Therefore, awake fiberoptic nasal intubation was performed.…”

Section: Case Descriptionmentioning

confidence: 99%

“…The thrombocytopenia was probably related to alcohol intake, as mild thrombocytopenia is common in individuals with excess alcohol intake. 2…”

Section: Case Descriptionmentioning

confidence: 99%

Anesthetic Management of a Patient with Madelung’s Disease Presenting with a Giant Cervical Lipoma: A Case Report

Chen Weng,

Tapia Salinas,

Noguera Tomas

et al. 2024

A&A Practice

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Madelung’s disease is characterized by the presence of multiple symmetric and nonencapsulated facial, neck, and upper trunk lipomas. Depending on the location and size of lipomas, there may be concerns for difficult airway management and cardiovascular collapse. We present the anesthetic management case of a patient with cervical and mediastinal lipomas who underwent elective cervical lipoma resection.

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Phosphoglycerate mutase 5 exacerbates alcoholic cardiomyopathy in male mice by inducing prohibitin‐2 dephosphorylation and impairing mitochondrial quality control

Tao,

Qiu,

Zheng

et al. 2024

Clinical & Translational Med

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BackgroundThe induction of mitochondrial quality control (MQC) mechanisms is essential for the re‐establishment of mitochondrial homeostasis and cellular bioenergetics during periods of stress. Although MQC activation has cardioprotective effects in various cardiovascular diseases, its precise role and regulatory mechanisms in alcoholic cardiomyopathy (ACM) remain incompletely understood.MethodsWe explored whether two mitochondria‐related proteins, phosphoglycerate mutase 5 (Pgam5) and prohibitin 2 (Phb2), influence MQC in male mice during ACM.ResultsMyocardial Pgam5 expression was upregulated in a male mouse model of ACM. Notably, following ACM induction, heart dysfunction was markedly reversed in male cardiomyocyte‐specific Pgam5 knockout (Pgam5cKO) mice. Meanwhile, in alcohol‐treated male mouse‐derived neonatal cardiomyocytes, Pgam5 depletion preserved cell survival and restored mitochondrial dynamics, mitophagy, mitochondrial biogenesis and the mitochondrial unfolded protein response (mtUPR). We further found that in alcohol‐treated cardiomyocyte, Pgam5 binds Phb2 and induces its dephosphorylation at Ser91. Alternative transduction of phospho‐mimetic (Phb2S91D) and phospho‐defective (Phb2S9A) Phb2 mutants attenuated and enhanced, respectively, alcohol‐related mitochondrial dysfunction in cardiomyocytes. Moreover, transgenic male mice expressing Phb2S91D were resistant to alcohol‐induced heart dysfunction.ConclusionsWe conclude that ACM‐induced Pgam5 upregulation results in Pgam5‐dependent Phb2S91 dephosphorylation, leading to MQC destabilisation and mitochondrial dysfunction in heart. Therefore, modulating the Pgam5/Phb2 interaction could potentially offer a novel therapeutic strategy for ACM in male mice.Highlights Pgam5 knockout attenuates alcohol‐induced cardiac histopathology and heart dysfunction in male mice. Pgam5 KO reduces alcohol‐induced myocardial inflammation, lipid peroxidation and metabolic dysfunction in male mice. Pgam5 depletion protects mitochondrial function in alcohol‐exposed male mouse cardiomyocytes. Pgam5 depletion normalises MQC in ACM. EtOH impairs MQC through inducing Phb2 dephosphorylation at Ser91. Pgam5 interacts with Phb2 and induces Phb2 dephosphorylation. Transgenic mice expressing a Ser91 phospho‐mimetic Phb2 mutant are resistant to ACM.

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Extrahepatic Manifestations in Alcoholic Liver Disease

Cited by 7 publications

References 143 publications

Alcoholic cardiomyopathy in patients with alcoholic liver cirrhosis: a study across 10 years

Alcoholic cardiomyopathy in patients with alcoholic liver cirrhosis: a study across 10 years

Anesthetic Management of a Patient with Madelung’s Disease Presenting with a Giant Cervical Lipoma: A Case Report

Phosphoglycerate mutase 5 exacerbates alcoholic cardiomyopathy in male mice by inducing prohibitin‐2 dephosphorylation and impairing mitochondrial quality control

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