Extrahepatic Manifestations of Primary Biliary Cholangitis

Chalifoux, Sara; Konyn, Peter; Choi, Gina; Saab, Sammy

doi:10.5009/gnl16365

Cited by 83 publications

(58 citation statements)

References 104 publications

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“…PBC is often associated with extrahepatic autoimmune disorders, such as Sjögren syndrome, thyroid disorders, systemic sclerosis, and rheumatoid arthritis. 4 …”

Section: Introductionmentioning

confidence: 99%

IgM-Positive Tubulointerstitial Nephritis Associated With Asymptomatic Primary Biliary Cirrhosis

Mizoguchi

Katayama

Murata

et al. 2018

Kidney International Reports

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“…PBC is often associated with extrahepatic autoimmune disorders, such as Sjögren syndrome, thyroid disorders, systemic sclerosis, and rheumatoid arthritis. 4 …”

Section: Introductionmentioning

confidence: 99%

IgM-Positive Tubulointerstitial Nephritis Associated With Asymptomatic Primary Biliary Cirrhosis

Mizoguchi

Katayama

Murata

et al. 2018

Kidney International Reports

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“…Bone mineral density loss is also common, and all patients with PBC should be offered calcium/vitamin D supplementation, and bisphosphonate therapy if osteoporotic. 4…”

Section: Primary Biliary Cholangitismentioning

confidence: 99%

An update on the management of cholestatic liver diseases

Appanna

Kallis

2020

Clinical Medicine

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An update on the management of cholestatic liver diseases Authors: Gautham Appanna A and Yiannis Kallis B Cholestatic liver diseases are a challenging spectrum of conditions arising from damage to bile ducts, leading to build-up of bile acids and inflammatory processes that cause injury to cholangiocytes and hepatocytes. Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are the two most common cholestatic disorders. In this review we detail the latest guidelines for the diagnosis and management of patients with these two conditions.

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“…Autoimmune thyroid diseases (AITD), featured by the production of autoantibody which induced by abnormal autoimmune responses and targets thyroid cells, is a class of organ-specific autoimmune disease, and mainly including Hashimoto's thyroiditis (HT) and Graves' disease (GD). AILD frequently overlap other extrahepatic autoimmune disease (EHAID) [1][2][3], AITD is the commonest concurrent EHAID in AILD patients (10-23%) [4][5][6]. The high incidence of AILD concomitant with AITD may be closely relevant to its underlying pathogenesis.…”

Section: Introductionmentioning

confidence: 99%

Immunological relationship between autoimmune liver disease and autoimmune thyroid disease:a cross-sectional study

Zeng

Gao

Wang

et al. 2019

Preprint

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Background: High prevalence of autoimmune thyroid disease (AITD) in patients with autoimmune liver disease (AILD) has been observed. Data on the clinical relationship between AILD and AILD remain scanty. We aimed to evaluate the immunological relationship between AILD and AITD. Results: 324 patients with AILD were enrolled, 113 out of 324 patients were concurrent AITD (34.9%). Patients with autoimmune hepatitis (AIH) were more likely to develop AITD (45.8%), followed by autoimmune hepatitis-primary biliary cholangitis overlap syndrome (AIH-PBC OS) (39.5%) and PBC (22.6%). AILD patients with concurrent AITD showed higher levels of IgG (21.5 g/L vs 16.3 g/L, P<0.0001) and gamma globulin (γ-globulin)(27.1% vs 21.9%, P<0.0001), and IgG were positively correlated with thyroid antibodies [thymoglobulinantibody (TGAb), thyroid peroxidase antibody (TPOAb)] (r=0.396, 0.322; P<0.0001, P=0.002, respectively). The frequency of TPOAb positivity was highest in PBC patients with concurrent AITD (83.9%). The AIH concomitant with AITD had a higher nuclear homogenizing antinuclear antibody (ANA) positivity compared with the AIH alone (P=0.019). PBC patients with concurrent AITD were significantly older than the PBC patients without AITD (P=0.0004). Thyroid dysfunction in AILD patients with concurrent AITD was principally characterized by Hashimoto's thyroiditis (65.5%) and diffuse lesions were mainly indicated in thyroid ultrasound (53.1%). Conclusions: The high incidence of AILD concomitant with AITD, as well as the higher levels of serum IgG and γ-globulin, and the strong correlation between thyroid antibody and IgG, suggesting that we should strengthen the screening of autoimmune thyroid disease when diagnosing and treating autoimmune liver disease.

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Extrahepatic Manifestations of Primary Biliary Cholangitis

Cited by 83 publications

References 104 publications

IgM-Positive Tubulointerstitial Nephritis Associated With Asymptomatic Primary Biliary Cirrhosis

IgM-Positive Tubulointerstitial Nephritis Associated With Asymptomatic Primary Biliary Cirrhosis

An update on the management of cholestatic liver diseases

Immunological relationship between autoimmune liver disease and autoimmune thyroid disease:a cross-sectional study

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