Extraintestinal Manifestations of Celiac Disease: Early Detection for Better Long-Term Outcomes

Laurikka, Pilvi; Nurminen, Samuli; Kivelä, Laura; Kurppa, Kalle

doi:10.3390/nu10081015

Cited by 107 publications

(115 citation statements)

References 98 publications

(131 reference statements)

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“…In our study, we found the EIM prevalence in 87% of adult celiac patients. CD is frequently reported to be accompanied by bone, joint, liver, skin involvement and anemia (23). Osteoporosis is one of the most common EIM in adult celiac patients, especially in elderly patients and postmenopausal women.…”

Section: Discussionmentioning

confidence: 99%

“…Since even identical twins with CD may have completely different phenotypes, the balance between genetic and environmental factors is considered to be important. At least partially different pathogenic background of variable presentations of CD is supported by the unique appearance of serological markers in some of these cases (23). Also delayed in diagnosis of CD it was stated that as a result of the increase in gluten exposure, the rate of EIM increased and some findings regressed after diet compliance (2,32).…”

Section: Discussionmentioning

confidence: 99%

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Extraintestinal Manifestations Associated with Celiac Disease

Kayar¹,

Dertli²,

Sürmeli³

et al. 2019

Eastern J Med

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Celiac disease (CD) can affect almost all organs of the body, including the nervous system, liver, skin, reproductive and musculoskeletal systems. In this study, it is aimed to determine the prevalence of extra-intestinal manifestations (EIMs) in adult celiac patients and to investigate the factors affecting the development of EIMs. The study included 230 celiac patients who were diagnosed and followed-up in our clinics between 2015-2019. The demographic and anthropometric characteristics, initial admissi on complaints, disease duration and dietary compliance of the patients were documented. All EIMs that accompanied the celiac disease were recorded, and their relationship with risk factors was analyzed. The age range of the patients was 18-72 years, and the mean age was 33.4±10.6 years. One hundred seventy two (74.8%) patients were female and disease follow-up was 4.8±3.5 years. The number of patients with accompanying EIMs was 202 (87.8%). Osteoporosis/osteopenia was found in 146(63.5%) patients, oral involvement in 116(50.4%) patients, arthritis/arthralgia in 96(41.7%) patients as the most common comorbidities. It was determined that, there was a significant relationship between EIM and body mass index. Although the EIMs development was less in patients wh o had strict diet; however, this was not statistically significant. The majority of adult celiac patients were found to be accompanied by EIMs. The diagnosis is delayed due to various clinical presentations. Lack of delay in diagnosis of celiac disease and consequently reduced gluten exposure seem to be the only factor in preventing some EIMs

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Extraintestinal Manifestations Associated with Celiac Disease

Kayar¹,

Dertli²,

Sürmeli³

et al. 2019

Eastern J Med

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“…Cøliaki er en glutenindusert, systemisk, autoimmun sykdom (20,21). Sykdommen blir diagnostisert både hos barn og voksne (20,22).…”

Section: Diskusjonunclassified

“…Sykdommen blir diagnostisert både hos barn og voksne (20,22). Det er i senere tid rettet større oppmerksomhet mot ikke-gastrointestinale symptomer og assosierte lidelser ved cøliaki (21). Studier viser at ekstra-intestinale manifestasjoner er meget vanlig (21,22), inkludert symptomer som kan ligne revmatiske sykdommer (21).…”

Section: Diskusjonunclassified

“…Det er i senere tid rettet større oppmerksomhet mot ikke-gastrointestinale symptomer og assosierte lidelser ved cøliaki (21). Studier viser at ekstra-intestinale manifestasjoner er meget vanlig (21,22), inkludert symptomer som kan ligne revmatiske sykdommer (21). Sarkoidose og cøliaki er assosiert med bestemte vevstyper, HLA-DR3 og HLA-DQ2 (23,24), der sistnevnte forelå hos vår pasient.…”

Section: Diskusjonunclassified

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En kvinne i 40-årene med bekkensmerter og uklare MR-funn

Brattås¹,

Gjelberg²,

Dizdar³

et al. 2019

Tidsskriftet

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Coeliac disease re‐screening among once seronegative at‐risk relatives: A long‐term follow‐up study

et al. 2022

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Background: Serological screening of the relatives of coeliac disease patients is widely endorsed. However, the need for and the optimal timing of possible retesting of once seronegative at-risk individuals for coeliac disease remain unclear.Objective: We investigated this issue by inviting a large cohort of previously screening-negative relatives of patients with coeliac disease to participate in a follow-up study. Methods: Altogether 599 relatives of coeliac disease index patients not diagnosed with coeliac disease in a screening study carried out in 2006-2010 were asked about possible later diagnosis or re-tested with coeliac disease autoantibodies in 2017-2021. Besides incidence, the possible impact of various patient-related clinical factors and HLA haplotype on the later diagnosis or screening positivity was examined.Results: Fifteen (2.5%) relatives were either diagnosed with a coeliac disease (n = 8) during the follow-up period or were found to be screening-positive in the re-testing (n = 7), giving a combined annual incidence of 221/100,000 person-years in all relatives and 336/100,000 among those carrying coeliac disease-associated HLA DQ2/DQ8. The new cases more often carried the high-risk (DQ2.5/2.5 or DQ2.5/ 2.2; 35.7% vs. 7.4%, respectively, p < 0.001) HLA and were younger at initial screening (23.3 vs. 40.5 years, p = 0.028) and -in spite of a negative screening outcome -had higher median transglutaminase antibody level in the first study than those not affected. There were no significant differences between the affected and non-affected relatives in other demographic data, degree of kinship with the index, current symptoms or frequency of chronic co-morbidities. Conclusion:The incidence rate for later coeliac disease diagnosis or new seropositivity in relatives who had been tested once was 221/100,000 person-years in all and 336/100,000 among those carrying at-risk HLA genetics after ∼10 years of follow-up. HLA-typing could help to target a subgroup of relatives who would benefit most from re-testing.

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Extraintestinal Manifestations of Celiac Disease: Early Detection for Better Long-Term Outcomes

Cited by 107 publications

References 98 publications

Extraintestinal Manifestations Associated with Celiac Disease

Extraintestinal Manifestations Associated with Celiac Disease

En kvinne i 40-årene med bekkensmerter og uklare MR-funn

Coeliac disease re‐screening among once seronegative at‐risk relatives: A long‐term follow‐up study

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