Extraintestinal manifestations of Edwardsiella tarda infection

Abstract

Summary Edwardsiella tarda, a member of the family Enterobacteriaceae, is a rare human pathogen. Gastroenteritis is the most frequently reported manifestation of E. tarda infection. In contrast, extraintestinal infection with E. tarda has rarely been reported. This study made a retrospective case and microbiological data review of patients with extraintestinal E. tarda infections to further understand this disease. This study retrospectively reviewed the charts of all isolates of E. tarda cultures from clinical specimens other than faeces at Chang Gung Memorial Hospital, Taoyuan, Taiwan from October 1998 through December 2001. Edwardsiella tarda was isolated from 22 clinical specimens from 22 hospitalised patients (13 females and nine males). The extraintestinal manifestations of E. tarda infection included biliary tract infection, bacteraemia, skin and soft tissue infection, liver abscess, peritonitis, intra-abdominal abscess, and tubo-ovarian abscess. The major underlying diseases predisposing to E. tarda extraintestinal infection were hepatobiliary diseases, malignancy and diabetes mellitus. The overall mortality rate of E. tarda extraintestinal infection in the present series was 22.7% (5/22), and four (40%) of 10 patients with bacteraemia expired. Although rare, human E. tarda extraintestinal infections can have diverse clinical manifestations and moreover may cause severe and life-threatening infections. Consequently, E. tarda should be considered a potentially important pathogen.

Epidemiological cut-off values for disc diffusion data generated by standard test protocols from Edwardsiella tarda and Vibrio harveyi

“…E. tarda has also been reported as a rare human pathogen. Gastroenteritis is the most frequently reported manifestation of E. tarda infections of humans, but extra-intestinal infections have been recorded (Wang et al 2005).…”

Successful Treatment of a Patient with Sepsis and Liver Abscess Caused by <i>Edwardsiella tarda</i>

“…They develop in both immunocompromised hosts and in patients with DM, malignancy, hepatobiliary disease and haematological disease. Interestingly, it also develops in conditions associated with iron overload, status such as in patients demonstrating sickle cell disease, cirrhosis, leukemia and in neonates (2,3). Almost all E. tarda strains are susceptible to antibiotics with an activity against Gramnegative bacilli, including most beta-lactams, aminoglycosides, tetracyclines, fluoroquinolones and antifolates (12).…”

Urosepsis caused by Edwardsiella tarda

“…1,2 Extraintestinal infections, including endocarditis, empyema, hepatobiliary infection, peritonitis, intraabdominal abscess, osteomyelitis, wound infection, and meningitis, have been reported more infrequently. [2][3][4][5][6][7] In the present report, we describe a case of urosepsis caused by this organism.…”