Extraintestinal Manifestations of Inflammatory Bowel Disease in Middle Eastern Patients

Adam, Heba; Alqassas, Maryam; Saadah, Omar I.; Mosli, Mahmoud

doi:10.2991/jegh.k.200330.001

Cited by 14 publications

(11 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our data show that in 17.5% of patients with IBD that developed extraintestinal manifestations, arthropathy involvement was the most common, followed by skin manifestations and eye manifestations, similar data were reported in our country and North America [ 16 , 27 , 28 , 29 ]. A significant difference was noted in the prevalence of arthritis and osteoporosis between patients with CD and those with UC across the age groups, as shown in Table 1 .…”

Section: Discussionsupporting

confidence: 89%

A Study of the Epidemiology, Clinical, and Phenotypic Characteristics of Inflammatory Bowel Disease in the Northen-Central Region of Saudi Arabia

Al-Fawzan,

Al-Radhi,

Al-Omar

et al. 2023

Diagnostics

View full text Add to dashboard Cite

Background: Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), is becoming increasingly prevalent in Saudi Arabia. However, there is limited data on the characteristics and manifestations of IBD in this population. This study aimed to establish a multi-center database of patients with IBD in the Qassim region of Saudi Arabia to better understand the demographics, prevalence, and manifestations of IBD in this population. Methods: This retrospective study included patients diagnosed with IBD at three healthcare facilities in the Qassim region of Saudi Arabia. The patient’s demographic and clinical characteristics, disease location and behavior, age at diagnosis, medication use, related surgeries, and extraintestinal manifestations were recorded based on the Montreal classification. A total of 257 patients with IBD were included in the study, of which 126 had UC and 131 had CD. Results: Of the 257 patients with IBD, 134 (52.2%) were male and 123 (47.8%) were female. The mean age of patients with CD and UC were 28.74 (range 15–67) and 38.79 (range 15–75) years, respectively. There was a significant difference between all age groups (p < 0.005), with more patients aged over 40 years being diagnosed with UC. UC was most commonly classified as left-sided UC (E2) (60; 47.6%), while the most common location of CD was the ileocolon (L3) (76; 58%). Non-stricturing and non-penetrating CD was the most common behavior (B1) (70; 53.8%). Approximately one-third of the patients with Crohn’s disease developed perianal disease (70; 27.2%), with fistulizing Crohn’s being the most prevalent manifestation (40; 30.5%), followed by abscess formation (10; 7.6%) and fissures (9; 6.8%). The most common extraintestinal manifestation was arthropathy (15; 5.8%). Significant p-values were detected for UC and CD (p = 0.036). Conclusions: This study provides crucial insights into the demographics, patterns, and manifestations of IBD in Saudi Arabia. The findings highlight the need for improved diagnosis, management, and treatment strategies for IBD in this population. The establishment of a multi-center database will help to facilitate future research and improve patient care in Saudi Arabia.

show abstract

Section: Discussionsupporting

confidence: 89%

A Study of the Epidemiology, Clinical, and Phenotypic Characteristics of Inflammatory Bowel Disease in the Northen-Central Region of Saudi Arabia

Al-Fawzan,

Al-Radhi,

Al-Omar

et al. 2023

Diagnostics

View full text Add to dashboard Cite

show abstract

“…Ulcerative colitis and Crohn's disease are systemic diseases classified as chronic inflammatory bowel disease (IBD) (81). Periodontitis, aphthous stomatitis, and in severe cases, pyostomatitis vegetans are particularly pronounced in patients with Crohn's disease (81,82). Patients in the acute phase of the disease show a significantly higher degree of oral lesions (83).…”

Section: Gastrointestinal Diseases Ulcerative Colitis and Crohn's Dis...mentioning

confidence: 99%

Systemic Diseases with Oral Manifestations and Their Impact on Health-Related Quality of Life

Vujović

Desnica

Stanišić

et al. 2022

Experimental and Applied Biomedical Research (EABR)

View full text Add to dashboard Cite

Health-related quality of life is a multidimensional concept established to evaluate the physical, psychological, and social impacts of health conditions on individuals’ well-being. Various tools for measuring health-related quality of life can be categorized into two subsets: generic and disease–specific instruments. The oral cavity can be stricken by a broad range of local and systemic diseases and their systemic treatment modalities. The most common systemic illnesses associated with oral lesions are hematologic disorders, endocrinopathies, neurological disorders, gastrointestinal conditions, mucocutaneous and rheumatic diseases, and neoplastic processes. Their manifestations in the oral cavity are, in most cases, rather nonspecific but should not be overlooked. Oral health is one of the most important parts of overall health, thus it has been proposed that poor oral health may affect health–related quality of life. The presence of oral manifestations of systemic diseases has a negative impact on the daily functioning of patients, decreasing their overall well-being. This article will review the most common systemic diseases with oral manifestations and their impact on the health–related quality of life. Oral health researchers should put a stronger emphasis on the patient-reported quality of life as a primary outcome in future clinical trials. The significance of this area has still not been widely understood in the current dental literature even though it could help improve patients’ health-related quality of life.

show abstract

“…Inflammatory bowel disease can involve other organs of body in addition to gastrointestinal tract which is defined as extra-intestinal manifestations (EIM) 11 , 12 . The prevalence and incidence of EIMs varies between different organs.…”

Section: Introductionmentioning

confidence: 99%

A systematic review and meta-analysis of extra-intestinal manifestation of inflammatory bowel disease in the Eastern Mediterranean Region (EMRO) countries

Momayez Sanat,

Vahedi,

Malekzadeh

et al. 2024

Annals of Medicine &Amp; Surgery

View full text Add to dashboard Cite

Background: Inflammatory bowel disease which is subgrouped mainly to ulcerative colitis and Crohn’s disease is thought to be a multi-organ disease. Most organs can be involved in the disease course in addition to gastrointestinal tract involvement. In this systematic review we aimed to assess the prevalence of these manifestations in Eastern Mediterranean Regional Office (EMRO) countries. Method: The present systematic review and meta-analysis study was performed according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) guideline. Joanna Briggs Institute (JBI) Critical Appraisal Checklist was admired for the quality evaluation of the included studies. For determining the heterogeneity, we used Cochran test and I2 statistics. Result: Finally, 12 studies were included in our study. Based on the results of our study the prevalence of arthritis in ulcerative colitis and Crohn’s disease patients was 7.1% (95% CI: 2.6–18.2%) and 13.5% (95% CI: 2.6–47.3%), respectively. Prevalence of arthralgia in ulcerative colitis patients was 18.4% (95% CI: 14.3–23.3%). skin involvement prevalence was 9.9% (95% CI 4.7–19.6%) in inflammatory bowel disease (IBD) patients. ocular involvement prevalence was 7.2% (95% CI 17–25.8%) in IBD patients. PSC prevalence in ulcerative colitis and Crohn’s disease patients was 3.5% (95% CI: 1.7–7.3%) and 2.7% (95% CI: 1.3–5.5%), respectively. Conclusion: Based on the results of this study arthralgia and arthritis were the most common extra-intestinal manifestation of IBD followed by dermatologic and ocular involvements. This extra-intestinal manifestation can challenge the patients’ management and identifying their pattern is important during the disease course.

show abstract

Extraintestinal Manifestations of Inflammatory Bowel Disease in Middle Eastern Patients

Cited by 14 publications

References 33 publications

A Study of the Epidemiology, Clinical, and Phenotypic Characteristics of Inflammatory Bowel Disease in the Northen-Central Region of Saudi Arabia

A Study of the Epidemiology, Clinical, and Phenotypic Characteristics of Inflammatory Bowel Disease in the Northen-Central Region of Saudi Arabia

Systemic Diseases with Oral Manifestations and Their Impact on Health-Related Quality of Life

A systematic review and meta-analysis of extra-intestinal manifestation of inflammatory bowel disease in the Eastern Mediterranean Region (EMRO) countries

Contact Info

Product

Resources

About