Extraintestinal Manifestations of Pediatric Inflammatory Bowel Disease

Greuter, Thomas; Bertoldo, Fabio; Rechner, Roman; Straumann, Alex; Biedermann, Luc; Zeitz, Jonas; Misselwitz, Benjamin; Scharl, Michael; Rogler, Gerhard; Safroneeva, Ekaterina; Ali, Raja Affendi Raja; Braegger, Christian; Heyland, Klaas; Mueller, Pascal; Nydegger, Andreas; Petit, Laëtitia Marie; Schibli, Susanne; Furlano, Raoul I.; Spalinger, Johannes; Schäppi, Michela; Zamora, Samuel Antonio; Froehlich, Florian; Herzog, Denise; Schoepfer, Alain; Vavricka, Stephan R.

doi:10.1097/mpg.0000000000001455

Cited by 97 publications

(97 citation statements)

References 36 publications

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“…We could, however, not compare and confirm these findings with results of other larger cohorts [41,42]. Lastly, the overall frequency of EIMs or extraintestinal complications was similar in all age groups of patients with CD and those with UC, and to those of earlier reports [40,[43][44][45][46].…”

Section: Discussioncontrasting

confidence: 83%

“…Only for a n e m i a ,i np a t i e n t sw i t hd i s e a s eo n s e ta tl e s st h a n1 7y e a r s , the requirement of TNFα, as a marker for more severe disease yielded a difference (0/16 without TNFα vs. 14/33 with TNFα, P = 0.01). When taking surgery as a marker of (25, 25 (40, 123 (39,(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44) 39 (42, 0.8 Abscess 1 (13, 18 (29, 75 (24,(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29) 18 (20,(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29) 0.5 Abdominal fistul...…”

Section: Patients With Crohn's Diseasementioning

confidence: 99%

“…5-ASA 14 (78, 52-94) 19 (76, 55-91) 188 (74,(68)(69)(70)(71)(72)(73)(74)(75)(76)(77)(78)(79)(80) 65 (72, 62-81) 0.9 Systemic CS 7 (39, 11 (44, 129 (51,(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57) 35 (39, 0.2 Imunomodulators 15 (83, 18 (72, 124 (49,(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55) 42 (47, 0.005, 0.2 a,c, *, 0.04 a,d, * Calcineurin inhibitors 0 (0, 0-19) 1 (5, 17 (7,(4)(5)…”

Section: Ulcerative Colitis Patientsmentioning

confidence: 99%

“…Extraintestinal manifestations [n (%, 95% CI)] Arthralgia 1 (6, 7 (28, 77 (30,(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37) 39 (43, 0.009, 0.1 a,d, * Uveitis 0 (0, 0-19) 2 (8, 16 (6,(4)(5)(6)(7)(8)(9)(10) 5 (6,(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)…”

mentioning

confidence: 99%

“…, * Any type of extraintestinal manifestation 3 (17, 12 (48, 96 (38,(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44) 42 (47,…”

mentioning

confidence: 99%

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Age at disease onset of inflammatory bowel disease is associated with later extraintestinal manifestations and complications

Herzog

Fournier

Buehr³

et al. 2018

European Journal of Gastroenterology &Amp; Hepatology

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Section: Discussioncontrasting

confidence: 83%

Section: Patients With Crohn's Diseasementioning

confidence: 99%

Section: Ulcerative Colitis Patientsmentioning

confidence: 99%

mentioning

confidence: 99%

“…, * Any type of extraintestinal manifestation 3 (17, 12 (48, 96 (38,(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44) 42 (47,…”

mentioning

confidence: 99%

See 3 more Smart Citations

Age at disease onset of inflammatory bowel disease is associated with later extraintestinal manifestations and complications

Herzog

Fournier

Buehr³

et al. 2018

European Journal of Gastroenterology &Amp; Hepatology

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Epidemiology of Musculoskeletal Manifestations in Pediatric Inflammatory Bowel Disease: A Systematic Review

Ali

Schmidt

Piskin

et al. 2022

ACR Open Rheumatology

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Objective Pediatric inflammatory bowel disease (p‐IBD) is a chronic relapsing gastrointestinal disorder of childhood with long‐term morbidity. Several extraintestinal manifestations are described, the most common being joint pain and/or inflammation. However, patient and disease characteristics, treatments, and outcomes of p‐IBD‐associated musculoskeletal disease are not well established. Our study aims to summarize the recent literature on the epidemiology of musculoskeletal manifestations in p‐IBD in the era of biologics. Methods A systematic search of PubMed, Embase, Cochrane Library, Web of Science Core Collection, and Cumulative Index to Nursing and Allied Health Literature databases was performed with relevant keywords. Studies in English published from January 1, 2000, to December 21, 2020, were included. In total, 3893 articles were identified and screened. Study and population characteristics and outcomes of interest were recorded. Risk of bias assessment was performed using the Joanna Briggs Institute Critical Appraisal Tools. Results Thirteen studies were included for full review, which were primarily single‐center observational studies with retrospective or cross‐sectional designs. The diagnostic criteria and definitions used for musculoskeletal manifestations varied. Musculoskeletal manifestation prevalence ranged from 2% to 35%. Only one study assessed the response of musculoskeletal manifestations to biologics. Risk of bias demonstrated heterogeneity in study quality. Conclusion This is the first systematic review of musculoskeletal manifestations in p‐IBD. Analysis was limited because of variability in study design and data‐reporting methods. Definitions varied among included studies, with a clear lack in standardization. Our study demonstrates the need for standardized assessment of musculoskeletal manifestations of p‐IBD and further research to explore optimal management to advance care for this group of children.

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Prevalence and clinical features of chronic uveitis in pediatric inflammatory bowel diseases: A nationwide study

Maniscalco,

Scarallo,

Aloi

et al. 2024

J. pediatr. gastroenterol. nutr.

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Inflammatory bowel diseases (IBD) encompass a group of chronic inflammatory disorders primarily affecting the gastrointestinal tract but capable of impacting various organs, including the eye, with uveitis being the most common ocular condition. We assessed uveitis prevalence and clinical features in a nationwide cohort of pediatric IBD. Among 4229 cases, six patients (four Crohn's disease, one ulcerative colitis, and one unclassified IBD) were identified, resulting in an overall prevalence rate of 141.8 per 100,000 patients. Uveitis onset varied: two before IBD, two after, and two concomitantly. Symptomatic uveitis occurred in 2/6 patients, with anterior involvement in all cases. Median follow‐up was 3 years (interquartile range [IQR]: 2–4.75 years). At the last follow‐up, 5/6 patients exhibited quiescent IBD, while 4/6 had inactive uveitis. One patient had ocular complications. Uveitis is a rare but potentially complicating manifestation of pediatric IBD.

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Extraintestinal Manifestations of Pediatric Inflammatory Bowel Disease

Cited by 97 publications

References 36 publications

Age at disease onset of inflammatory bowel disease is associated with later extraintestinal manifestations and complications

Age at disease onset of inflammatory bowel disease is associated with later extraintestinal manifestations and complications

Epidemiology of Musculoskeletal Manifestations in Pediatric Inflammatory Bowel Disease: A Systematic Review

Prevalence and clinical features of chronic uveitis in pediatric inflammatory bowel diseases: A nationwide study

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