Extralabel use of cabergoline in the treatment of a pituitary adenoma in a rat

Mayer, Jörg; Sato, Amy F.; Kiupel, Matti; DeCubellis, Julie; Donnelly, Thomas M.

doi:10.2460/javma.239.5.656

Cited by 21 publications

(22 citation statements)

References 30 publications

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“…[8][9][10][11] Prolactin secretion increases subsequent to a decrease in the secretion of dopamine from the pituitary gland in geriatric rats 12 and persistent low concentrations of progesterone, constant estrus, or cessation of ovulation in female rats. 7,13,14 In some laboratory rat strains, including the Sprague-Dawley, 12 Fisher, 15 and Wistar 16,17 strains, pituitary gland adenomas develop in > 80% of rats > 24 months old. Some geriatric rats with mammary gland fibroadenomas develop concurrent prolactin-secreting, lactotroph, pituitary gland tumors, but there is some debate whether those tumors are incidental findings given the high frequency of both tumor types in geriatric rats.…”

Section: Small Animals and Exoticmentioning

confidence: 99%

“…7,16 Prolactin-secreting adenomas are the most common type of pituitary gland tumor in laboratory rats. 12,16,17 Pituitary gland adenomas are classified as chromophobic, acidophilic, basophilic, or mixed on the basis of the staining affinities of the tumor cells. 12 Chromophobic adenoma is the most frequently classified type of pituitary gland tumor.…”

Section: Small Animals and Exoticmentioning

confidence: 99%

“…12,16,17 Pituitary gland adenomas are classified as chromophobic, acidophilic, basophilic, or mixed on the basis of the staining affinities of the tumor cells. 12 Chromophobic adenoma is the most frequently classified type of pituitary gland tumor. 7,12 In laboratory rats, pituitary gland tumors usually arise from the pars distalis, although tumors arising from the pars intermedia have been described, and pituitary gland carcinomas are rare.…”

Section: Small Animals and Exoticmentioning

confidence: 99%

“…12 Chromophobic adenoma is the most frequently classified type of pituitary gland tumor. 7,12 In laboratory rats, pituitary gland tumors usually arise from the pars distalis, although tumors arising from the pars intermedia have been described, and pituitary gland carcinomas are rare. 16 In companion rats, pituitary gland tumors have been reported in 3 females and 4 males 12,18 ; the tumor in one of the male rats was confirmed to be a prolactin-secreting pituitary gland adenoma.…”

Section: Small Animals and Exoticmentioning

confidence: 99%

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Description of the prevalence, histologic characteristics, concomitant abnormalities, and outcomes of mammary gland tumors in companion rats (Rattus norvegicus): 100 cases (1990–2015)

Vergneau‐Grosset

Keel

Goldsmith

et al. 2016

javma

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OBJECTIVE To describe the prevalence, histologic characteristics, concomitant abnormalities, and outcomes for various types of mammary gland tumors in companion rats (Rattus norvegicus). DESIGN Retrospective case series. ANIMALS 100 client-owned rats. PROCEDURES Medical records of companion rats that had an SC mass and were examined at a veterinary teaching hospital between 1990 and 2015 were reviewed. Information regarding the signalment, age at mass detection, reproductive sterilization status, histologic diagnosis of the SC mass, location of the initial and all subsequent SC masses, treatments administered, and clinical outcomes was extracted from each record and summarized. RESULTS 105 SC masses were initially detected in 100 rats. The most prevalent SC mass identified was mammary gland fibroadenoma (56/105 [53%]), followed by mammary gland carcinoma (13/105 [12%]). Overall, 26 of 105 (25%) masses were malignant. Sexually intact males were more likely to have nonmammary SC tumors than sexually intact females. In rats receiving no adjunctive treatment after excision of a mammary gland fibroadenoma (n = 16), a second fibroadenoma was detected 1 to 8 months after initial excision, at a median of 4.5 months after surgery. A concomitant pituitary gland tumor was identified in most rats with mammary gland fibroadenoma (21/28 [75%]) and other types of mammary gland tumors (10/17 [59%]). Fourteen of 35 (40%) rats with mammary gland fibroadenoma had concomitant reproductive tract abnormalities. CONCLUSION AND CLINICAL RELEVANCE Results suggested that, like other species, companion rats with SC masses should undergo a thorough diagnostic workup that includes histologic examination of the excised mass.

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Section: Small Animals and Exoticmentioning

confidence: 99%

Section: Small Animals and Exoticmentioning

confidence: 99%

Section: Small Animals and Exoticmentioning

confidence: 99%

Section: Small Animals and Exoticmentioning

confidence: 99%

See 2 more Smart Citations

Description of the prevalence, histologic characteristics, concomitant abnormalities, and outcomes of mammary gland tumors in companion rats (Rattus norvegicus): 100 cases (1990–2015)

Vergneau‐Grosset

Keel

Goldsmith

et al. 2016

javma

View full text Add to dashboard Cite

show abstract

“…Cabergoline, a prolactin inhibitor that suppresses pituitary prolactin secretion can be given orally. It has been successfully used in the reducing the size of a pituitary adenoma in a rat at a dose of 0.6 mg/kg PO q 72 h. 23 As in mammary tumors, rats fed on a restricted diet had the lowest incidence of pituitary adenomas and focal pituitary hyperplasia. 24 Chronic progressive nephrosis/nephropathy (CPN) is one of the more common causes of death in aged rats and the incidence has been reported as high as 75% in some strains (Sprague Dawley).…”

Section: Ratsmentioning

confidence: 99%