Extralymphatic involvement in diffuse non-Hodgkin's lymphoma.

Abstract

Between 1961 and 1982, 543 patients with diffuse histiocytic, mixed, or undifferentiated lymphoma were treated at Stanford University, Stanford, Calif. Of this group, 281 (52%) had extralymphatic lesions and the 111 patients with stage IE and IIE disease were subjected to analysis. Most patients (94) had diffuse histiocytic lymphoma. Lymphangiography was performed in 77%, bone marrow biopsy in 91%, and diagnostic or staging laparotomy in 52% of the patients. All but five patients were treated with megavoltage irradiation and 35 patients received combination chemotherapy. Median follow-up was 4.0 years. Kaplan-Meier actuarial survival at five and 10 years was 46% and 36%, respectively. Freedom from relapse (FFR) at five years was 49% with no relapses beyond that point. The most common extralymphatic sites were the gastrointestinal tract, the head and neck region, and the lung. Prognosis could not be correlated with the specific sites of involvement. Patients with bulky disease (greater than 10 cm) or more than three sites of involvement had a significantly lower survival and FFR. There was no significant difference in outcome for patients treated with irradiation or combined modality therapy. Most patients (62%) relapsed in distant extralymphatic sites.

False-positive F-18 FDG uptake in PET/CT studies in pediatric patients with abdominal Burkitt's lymphoma

“…The revised European-American lymphoma classification is among the most widely used and focuses on the distinction between B and T-cell neoplasms [4][5][6][7]. The gastrointestinal tract is the predominant site of extranodal NHLs [8][9][10][11][12][13].…”

EUS in the Evaluation of Gastric Tumors

“…Patients with DLBCL tend to have a more advanced-stage disease at initial presentation and present with severe systemic symptoms such as abdominal pain, gastric outlet obstruction, bleeding, or perforation. 56,57 Upper endoscopy may reveal large, multiple ulcers or protruding exophytic tumors. Histologic examinations reveal confluent sheets or clusters of large cells that resemble centroblasts or immunoblasts.…”

Multifocal Extranodal Lymphomas: An Expression of Homing Phenomenon

“…The present data clearly indicate that extranodal lesion can occur at multiple extranodal sites either at the initial presentation or at relapse of the disease. Paryani et al, [6] Among the extranodal sites simultaneously occurring in individual patients, a consistent preferential in volvement of the extranodal site is frequently ob served. The reason for this tropism is not clear, but it is likely that it is closely linked to the homing process regulated by homing receptors on lymphoid cells and ligands on high endothelial venules [7][8][9].…”