Extramammary Paget's Disease of the Perianal Region: A Review of the Literature Emphasizing Management

Bie, Mengjun; Wei, Zheng-Qiang; Tasleem, Mandarry Muhammad

doi:10.1111/dsu.12019

Cited by 40 publications

(36 citation statements)

References 51 publications

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“…Clinically, it shows a slowly expanding erythematous plaque frequently associated with pruritus and pain with occasional bleeding from ulcerated areas [2]. Minicozzi et al [5] found that 58% of cases were not associated with other neoplasia while 10% were associated with another synchronic or metachronic neoplasia, 1% was associated with adnexal neoplasia, and in nearly 30% of cases an intradermal spread of rectal carcinoma was found.…”

Section: Discussionmentioning

confidence: 99%

“…Minicozzi et al [5] found that 58% of cases were not associated with other neoplasia while 10% were associated with another synchronic or metachronic neoplasia, 1% was associated with adnexal neoplasia, and in nearly 30% of cases an intradermal spread of rectal carcinoma was found. For this reason, clinical evaluation should include sigmoidoscopy, cystoscopy, colposcopy and mammography [2].…”

Section: Discussionmentioning

confidence: 99%

“…The most reported are the use of photodynamic therapy, imiquimod 5% cream for topic use and even radiotherapy [2,4,7].…”

Section: Discussionmentioning

confidence: 99%

“…As noted in previous publications Perianal Paget's disease can be associated with synchronous or metachronous visceral malignancies [1]. This makes necessary to complete the study of the patient with a colonoscopy and imagery, such as CT scan [2]. And also imposes a long-term follow-up.…”

Section: Introductionmentioning

confidence: 96%

“…There are several non-surgical approaches described, such as radiotherapy, local application of imiquimod or interferon [2,4]. However, surgical treatment with negative margins is preferred when possible.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Surgical Treatment of a Perianal Paget's Disease: A Case Report and Short Review of the Literature

Nardi¹,

Daneri²

2016

J Hepatol Gastroint Dis

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Extra-mammary Paget's disease (EMPD) is a rare and slow progressive skin lesion located in the perineum, perianal region, groin, scrotum or vulva. Perianal Paget may be associated with synchronous or metachronous visceral malignancies which makes necessary a complete study of the patient. Clinical presentation varies and there has been proposed many types of treatments. This article presents a 71-year-old man with no medical history of relevance referred to our department with a perianal lesion that was diagnosed afterwards as a Perianal Paget Disease. Surgical excision was performed. The patient underwent uneventful recovery and the long term follow up is asymptomatic so far.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…The most reported are the use of photodynamic therapy, imiquimod 5% cream for topic use and even radiotherapy [2,4,7].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Surgical Treatment of a Perianal Paget's Disease: A Case Report and Short Review of the Literature

Nardi¹,

Daneri²

2016

J Hepatol Gastroint Dis

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Topical Combination of Fluorouracil and Calcipotriene as a Palliative Therapy for Refractory Extramammary Paget Disease

et al. 2019

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Inguinal and Scrotal Lesion

2015

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A man in his 60s presented for further evaluation of a right inguinal and scrotal lesion ( Figure 1). The rash initially started 4 years prior as a dime-sized, pink, scaly area in the right inguinal crease and was pruritic. Results of a biopsy at the time were consistent with lichen simplex chronicus, and treatment with topical steroids was initiated. Since then, the rash had failed to resolve and the affected area had increased in size to its present dimensions. The patient had a history of prostate cancer treated with prostatectomy 4 years previously without evidence of recurrence and melanoma of the posterior neck treated with wide local excision, in addition to non-insulindependent diabetes mellitus and hyperlipidemia controlled with oral medications. He does not smoke and has been in a monogamous marriage for more than 30 years. Examination revealed a multifocal scaly, pink-red beefy plaque in the right inguinal crease extending from the superior aspect of the scrotum to the gluteal crease measuring approximately 6 × 7 cm in total area with some areas of excoriation and superficial open wounds. An additional area of macular erythema extended superiorly along the inguinal crease toward the medial thigh. No lymphadenopathy of the inguinal region was noted.Quiz at jamaoncology.com Figure 1. Clinical photograph of a right inguinal and scrotal lesion.

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Extramammary Paget's Disease of the Perianal Region: A Review of the Literature Emphasizing Management

Cited by 40 publications

References 51 publications

Surgical Treatment of a Perianal Paget's Disease: A Case Report and Short Review of the Literature

Surgical Treatment of a Perianal Paget's Disease: A Case Report and Short Review of the Literature

Topical Combination of Fluorouracil and Calcipotriene as a Palliative Therapy for Refractory Extramammary Paget Disease

Inguinal and Scrotal Lesion

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