Extramedullary Hematopoiesis, Mediastinal Masses, and Spinal Cord Compression

Spinal Cord Compression in Homozygous Beta-Thalassemia Intermedia

“…The clinical presentation has been most frequently reported to occur during the 3rd and 4th decades of life, and only 4 of these cases [3][4][5] belong to the pediatric age group. A possible explanation for this phenomenon may consist in the rather long period of time required by the compensatory proliferative mechanism to become symptomatic and cause cord compression [4], Close et al [ 10] T5-T12 radiotherapy Sorsdahl et al [9] intermedia T5-T8 total none Hongladarom et al [7] T7-T9 none Cauthen et al [6] intermedia T4-T8 total none intermedia T4-T8 subtotal radiotherapy Luyendijk et al [18] homozygous T5-T7 subtotal radiotherapy Cross etal. [11] intermedia T4-T9 subtotal radiotherapy Cross et al [8] intermedia T6 subtotal radiotherapy Mihindukulasurya et al [8] T6 total none Prabhakar et al [ 1 ] homozygous T7-TI0 subtotal radiotherapy Issaragrisil et al [16] T4-T11 radiotherapy Abassioun and Amir-Jamshidi [3] T4-T11 subtotal radiotherapy Luitjes et al [ 17] homozygous T4-T8 subtotal radiotherapy David and Balasubramaniam [14] T4-T8 subtotal radiotherapy Ibrahim et al [5] homozygous T4-T8 subtotal none Mann et al [12] heterozygous T3-T8 subtotal transfusional Amirjamshidi et al [4] homozygous T9-TI0 total transfusional intermedia T5-T1I subtotal radiotherapy Present study intermedia T3-T8 total transfusional There is still a controversy regarding the optimal man agement of these patients.…”

Spinal Cord Compression in Myelofibrosis—a Case Report

“…Radiotherapy is reported to be well tolerated, with only one author (6) reporting significant toxicity [ myelosuppression) perhaps rebated to large radiation fields. Surgical morbidity is poorly documented, but complications, such as severe haemorrhage (2,7,8), in the context of often incompletely resectable disease would seem to recommend radiation as the primary treatment modality.…”

Obstructive uropathy due to extramedullary haematopoiesis in beta thalassaemia/haemoglobin E

“…An 18 year old woman with the diagnosis of beta thalassaemia/haemoglobin E since the age of 10 years presented with a slowly progressive enlarged pelvic mass of 2 months duration. She had received 6-10 units of packed red cells annually and the haemoglobin level ranged between 5 and 7 g/dl.…”