Extramedullary Plasmacytoma Diagnosed by Fine Needle Aspiration Cytology

Cytodiagnosis of Extramedullary Plasmacytomas

“…Rarely do they present as localized disease. 7 EMPs are rare tumors and can be mistaken for lymphomas or carcinomas, depending upon the location. 6 The morphologic diagnosis of plasma cell tumors is [4][5][6][7][8][10][11][12][13][14] The utility of FNAC as a front-line investigative procedure for the diagnosis of plasmacytoma is highlighted by Bangerter et al 4 and Das et al 5 They reported the presence of anaplastic plasma cells in most cases of EMP.…”

“…Inflammatory or reactive plasmacytosis is often composed of a polymorphous collection of segmented and mononuclear leukocytes in varying proportions. 7 Immunocytochemical study and DNA ploidy by flow cytometry are useful to differentiate poorly differentiated plasmacytomas from immunoblastic lymphomas and poorly differentiated carcinomas. Neoplastic plasma cells, in the majority of cases, express monotypic cytoplasmic immunoglobulin and plasma cell antigens CD38, CD138 and Vs38c.…”

Letter to the Editor

“…Pai and Raghuveer [9] reported on 4 cases of EMPs diagnosed by FNA biopsy, but all these cases represented extraosseous manifestations of multiple myeloma. Bangerter et al [7], reported on the FNA cytologic findings of 18 patients with EMP, with 16 patients having multiple myeloma.…”

Plasmacytoma of the Breast

“…Fine needle aspiration biopsy has been performed in the evaluation of extramedullary plasmacytomas of the soft tissue, [17][18][19][20] lymph nodes 19,20 and bone, 19 thus avoiding open surgical procedures.…”