Extramedullary plasmacytoma of stomach

Abstract

A case report and an analysis of 12 additional reported cases of plasmacytoma of the stomach are presented. No specific clinical or laboratory findings characterized this disease. Grossly, the lesions resembled carcinoma and are classified as nodular, infiltrative, ulcerative, and polypoid. Like lymphoma, it may present a multinodular pattern with multiple ulcerations in roentgenograms. Surgery is the therapy of choice, followed by radiation. For disseminated Iesions, radiation and/or chemotherapy produce tumor regression. Plasmacytoma involved small and/or large intestines in 5 cases; esophagus was never invohed. Ten patients died in 5 years-6 of gastric plasmacytoma, 4 of postoperative complications. Five cases had disseminations; 2 showed bone involvement.LASMA CELL NEOPLASMS ARE USUALLY CLASSI-P fied as multiple myeloma when tumors are dispersed in the skeletal system; solitary myeloma or plasmacytoma when they appear as a single focus in a bone; extramedullary plasmacytoma when they involve extraosseous structures; and, plasma cell leukemia when abnormal plasmacytes invade the peripheral blood. Hellwigs reviewed 127 published cases of extramedullary plasmacytoma in 1943; he found the upper respiratory tract as the most common site, followed by the conjunctiva. Occurrences in the gastrointestinal tract and thyroid were extremely sparse. Plasmacytomas of the conjunctiva were found to be benign, frequently associated with trachoma, and occurring in young females, whereas, those found in the upper respiratory tract were malignant in about 50y0 of instances. Hellwigs emphasized the inconsistent correlation of the cytologic differentiation of the tumor with its clinical behavior. H e established as his criteria for malignancy destructive changes of surrounding tissues and metastases to lymph nodes and/or bone(s). In 1928, Vasiliu reported 3 patients with extramedullary plasmacytoma of the gastrointestinal tract. One patient had multiple lesions situated in the stomach, 3 small intes-From Mary Immaculate Hospital Div., Catholic Med-*

Radiologic Findings of Multiple Myeloma with Gastric Involvement: A Case Report

“…Patients with gastric myeloma have presented with nonspecific gastrointestinal symptoms such as epigastric pain, weight loss, and upper gastrointestinal bleeding (1-4). Pathologically, gastric myeloma is thought to originate from lymphoid follicles in the submucosa, or from plasma cells in the submucosa or mucosal lamina propria (5). Early gastric myeloma is confined to the mucosa or submucosa of the gastric wall.…”

“…Gastric myeloma can manifest in various forms: nodular, infiltrative, ulcerative, and polypoid (5), among which the nodular type is most common. In our case the infiltrative form occurred, manifesting as diffuse thickening of the anterior wall of the gastric cardia and along the greater curvature of the body.…”

Solitary extramedullary plasmacytoma in the retroperitoneum

“…Extramedullary plasmacytoma is relatively rare as compared with solitary plasmacytoma of bone and multiple myeloma [1][2][3]. Most cases of extramedullary plasmacytoma occur in the upper respiratory tract, oral cavity, or gastrointestinal tract [1,3,4]. In this report, we describe a solitary extramedullary plasmacytoma in the retroperitoneum in a young adult presenting with prominent obstructive jaundice and inferior vena cava thrombosis.…”

“…Plasma cell neoplasms are classified into four groups: solitary plasmacytoma of bone, extramedullary plasmacytoma, multiple myeloma, and plasma cell leukemia [1]. Extramedullary plasmacytoma is relatively rare as compared with solitary plasmacytoma of bone and multiple myeloma [1][2][3].…”

Polypoide Magenbeteiligung beim Plasmozytom

“…Des Weiteren finden sich okkultes Blut im Stuhl, Meläna und eine Eisenmangelanämie [5]. Endoskopisch stellen sich ulzerierende oder polypöse Läsionen dar.…”