Extramedullary Plasmacytoma of the Trachea

Saxena, Renu; Nair, Rekha A.; Jacob, Priya Mary; Koshy, Sumod Mathew; Mathew, Arun Peter

doi:10.1007/s12105-013-0491-7

Cited by 13 publications

(16 citation statements)

References 14 publications

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“…With the assistance of adhesion molecules, pathologic plasmablasts may settle in soft tissue or in an extracellular connective tissue area, which is the origin of EMP 2. The etiology of these lesions is not well understood, but viral pathogenesis and chronic irritation have been suggested to be contributing factors 3,7. The median age of presentation of EMP is 55 years, with a male/female ratio of 3:1 6.…”

Section: Discussionmentioning

confidence: 99%

“…The median age of presentation of EMP is 55 years, with a male/female ratio of 3:1 6. The predominant site of EMP is the head and neck region, and tracheal involvement is rare, constituting only 0.1% of all malignancies 1,3…”

Section: Discussionmentioning

confidence: 99%

“…EMP constituteŝ4% of all plasma cell neoplasms, occurring mostly in the upper aerodigestive tract (UAD) but also rarely arising in the soft tissues, gastrointestinal tract, skin, and lymph nodes 2. The trachea is a very rare site of plasmacytoma, and no more than 20 cases were reported in the medical literature until 2014 3–5. Here, we report a case of multiple EMPs involving the trachea, laryngopharynx, and oropharynx that caused symptoms of airway obstruction as the first clinical manifestation.…”

Section: Introductionmentioning

confidence: 99%

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<p>Multiple extramedullary plasmacytomas of the trachea and pharyngeal tissue: a case report and literature review</p>

Tang¹,

Wang²,

Liang³

et al. 2019

OTT

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Extramedullary plasmacytoma (EMP) is an infrequent form of plasma cell dyscrasia that presents as a mass of monoclonal plasma cells located in extramedullary soft tissues with no skeletal component. EMP constitutes ~4% of all plasma cell neoplasms and occurs mostly in the upper respiratory tract. Here, we report a rare case of multiple EMPs involving the trachea, laryngopharynx, and oropharynx, which caused symptoms of airway obstruction as the only clinical manifestation. The patient was diagnosed by histopathology of the tissue from bronchoscopic resection and successfully managed with bronchoscopic intervention to treat lesions in the trachea and radiotherapy combined with surgical resection to treat lesions in the pharynx. There was no recurrence after 14 months of follow-up. Endoscopic intervention plays a key role in the rapid diagnosis and treatment of EMP involving the central airways.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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<p>Multiple extramedullary plasmacytomas of the trachea and pharyngeal tissue: a case report and literature review</p>

Tang¹,

Wang²,

Liang³

et al. 2019

OTT

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“…When an extramedullary plasmacytoma (EPT) is suspected, it is mandatory to exclude an MM and some kinds of non-Hodgkin lymphomas, particularly lymphoplasmocytic lymphoma and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (lymphoma). [ 4 5 ]…”

Section: Discussionmentioning

confidence: 99%

“…Less than twenty cases were reported in the medical literature until 2013. [ 4 5 ] Durris et al . reviewed 18 cases of tracheobronchial plasmacytoma with tracheal location in 13 of them.…”

Section: Introductionmentioning

confidence: 99%

Rare tracheal tumor

Stevic

Ercegovac

Stojšić

et al. 2018

Journal of Postgraduate Medicine

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Primary tracheal tumors are rare and trachea is an exceedingly rare site of extramedullary plasmacytoma (EMP). We report a case of solitary tracheal plasmacytoma causing symptoms of airway obstruction in a 59-year-old man. Flow/volume loop indicated the fixed central airway obstruction. Computerized tomography and bronchoscopy demonstrated a sessile tumor on posterior tracheal wall obstructing 80% of the lumen. Partial tracheal resection with T-T anastomosis was performed. Pathologic analysis of resected mass revealed EMP. Additional investigations excluded multiple myeloma. There are no signs of disease recurrence after 7-year follow-up.

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A Comparative Study of the Effects of Different Decellularization Methods and Genipin-Cross-Linking on the Properties of Tracheal Matrices

Zhong

Jiang

Sun

et al. 2018

Tissue Eng Regen Med

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BACKGROUND: Different decellularization methods can affect the integrity and the biomechanical and biocompatible properties of the tracheal matrix. Natural cross-linking with genipin can be applied to improve those properties. The goals of this study were to evaluate the effects of different decellularization methods on the properties of genipin-cross-linked decellularized tracheal matrices in rabbits. METHODS: The tracheas of New Zealand rabbits were decellularized by the Triton-X 100-processed method (TPM) and the detergent-enzymatic method (DEM) and were then cross-linked with genipin. Mechanical tests, haematoxylin-eosin staining, Masson trichrome staining, Safranin O staining, DAPI staining, scanning electronic microscopy (SEM), and biocompatibility tests were used to evaluate the treatment. The bioengineered trachea and control trachea were then implanted into allogeneic rabbits for 30 days. The structural and functional analyses were performed after transplantation. RESULTS:The biomechanical tests demonstrated that the biomechanical properties of the decellularized tracheas decreased and that genipin improved them (p \ 0.05). The histological staining results revealed that most of the mucosal epithelial cells were removed and that the decellularized trachea had lower immunogenicity than the control group. The analysis of SEM revealed that the decellularized trachea retained the micro-and ultra-structural architectures of the trachea and that the matrices cross-linked with genipin were denser. The biocompatibility evaluation and in vivo implantation experiments showed that the decellularized trachea treated with the DEM had better biocompatibility than that treated with the TPM and that immunogenicity in the cross-linked tissues was lower than that in the uncross-linked tissues (p \ 0.05). CONCLUSIONS: Compared with the trachea treated with the TPM, the rabbit trachea processed by the DEM had better biocompatibility and lower immunogenicity, and its structural and mechanical characteristics were effectively improved after the genipin treatment, which is suitable for engineering replacement tracheal tissue.

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Extramedullary Plasmacytoma of the Trachea

Cited by 13 publications

References 14 publications

<p>Multiple extramedullary plasmacytomas of the trachea and pharyngeal tissue: a case report and literature review</p>

<p>Multiple extramedullary plasmacytomas of the trachea and pharyngeal tissue: a case report and literature review</p>

Rare tracheal tumor

A Comparative Study of the Effects of Different Decellularization Methods and Genipin-Cross-Linking on the Properties of Tracheal Matrices

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