Extramembranous glomerulonephritis inchildren: Report of 50 cases

Habib, R; Kleinknecht, C; Gubler, Marie–Claire

doi:10.1016/s0022-3476(73)80063-0

Cited by 111 publications

(66 citation statements)

References 15 publications

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“…This MPGN-like lesion associated with dominant IgA deposition has been reported previously in children (Habib et al 1973(Habib et al , 1974Iitaka et al 2003). Iitaka et al (2003) reported a similar case, entitled "IgA-associated glomerulonephritis with membranoproliferative glomerulonephritis-like pattern in two children."…”

Section: Discussionsupporting

confidence: 75%

“…Second, primary MPGN usually shows low serum C3 associated with predominant C3 deposition. Hypocomplementemia is considered to be present in about 50% of cases at the initial onset time and 80-95% during the course (West et al 1965;Habib et al 1973;Iitaka et al 1995), whereas these patients showed no hypocomplementemia during the entire period. In the present patient, the lack of hypocomplementemia, intensive IgA as well as IgG deposition, and favorable prognosis do not positively support the diagnosis of MPGN.…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of IgAN is 30-40% of all biopsied patients or all patients with primary glomerulonephritis (Nakamoto et al 1978;Johnston et al 1992;Koyama et al 1997). However, infantile onset IgAN is rare (Habib et al 1973(Habib et al , 1974Koyama et al 1997).…”

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confidence: 99%

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Infantile Immunoglobulin A Nephropathy Showing Features of Membranoproliferative Glomerulonephritis

Kurosu

Oka

Hamaguchi

et al. 2012

Tohoku J. Exp. Med.

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Immunoglobulin A nephropathy (IgAN) showing predominant IgA and complement 3 (C3) deposition on the mesangium is an immune complex-mediated glomerulonephritis. This renal disease is the most common primary glomerular disease worldwide. However, infantile onset of IgAN is rare. In the present patient, urinary protein and occult blood were detected in a girl aged 1 year and 8 months on urinalysis at a nursery school. Despite being young, a kidney biopsy was performed for diagnosis and the correct choice of therapy. Glomerular mesangial cell proliferation and a double contour of the glomerular basement membrane (GBM) resembling a railroad track were noted on light microscopy. Therefore, the patient was diagnosed morphologically with membranoproliferative glomerulonephritis (MPGN), because mesangial hypercellularity and thickening of the GBM were identified. However, on immunofluorescent staining, the deposition of immune complexes mainly consisting of IgA, IgG, and C3 was noted in the mesangial region and glomerular capillary loops. On electron microscopy, electron-dense deposits were recognized in the subendothelial and paramesangial regions associated with mesangial cell interposition into the subendothelial space. Autoimmune diseases and infection-associated secondary glomerulonephritis were clinically excluded, because there were no relevant signs or symptoms. Steroid treatment was initiated and findings of urinalysis were normalized within 8 months. This patient was finally diagnosed with IgA nephropathy showing the features of MPGN. The present patient was the youngest among reported cases of IgA nephropathy, suggesting that early onset of IgAN is associated with an MPGN-like lesion. The present report provides information for pathogenesis of IgA nephropathy.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

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Infantile Immunoglobulin A Nephropathy Showing Features of Membranoproliferative Glomerulonephritis

Kurosu

Oka

Hamaguchi

et al. 2012

Tohoku J. Exp. Med.

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“…M embranous glomerulonephritis (MGN) is a chronic glomerular disease with nephrotic or nonnephrotic proteinuria (1,2). The characteristic histopathologic features of MGN are a diffusely thickened glomerular capillary wall that exhibits projections or spikes under light microscopy, fine granular staining for IgG and complement along the glomerular capillary wall on immunofluorescence microscopy, and electron-dense deposits (EDD) in the subepithelial area on electron microscopy (3).…”

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confidence: 99%

Segmental Membranous Glomerulonephritis in Children

Obana¹,

Nakanishi²,

Sako³

et al. 2006

Clinical Journal of the American Society of Nephrology

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Generally, idiopathic membranous glomerulonephritis (MGN) is a global glomerular disease that affects the whole of the glomerulus. However, idiopathic segmental MGN (SMGN) that shows IgG deposits in a portion of the glomerulus is encountered often. For clarification of whether SMGN is the same entity as idiopathic global MGN (GMGN), the two diseases were compared. From 1978 to 2004, 38 children (11 with SMGN and 27 with GMGN) received a diagnosis of idiopathic MGN. Immunofluorescence microscopy showed segmental granular IgG staining along the capillary loops in SMGN, whereas GMGN showed global staining. On light microscopy, SMGN showed segmental thickening of the glomerular basement membrane, with spike formation, whereas GMGN showed global lesions. The frequency of C1q deposits in SMGN was significantly higher than that in GMGN (91 versus 41%; P < 0.01). On electron microscopy, mesangial electron-dense deposits were detected in 10 (91%) cases of SMGN and also were found in the subepithelial and intramembranous area, whereas only six (22%) cases of GMGN had mesangial electron-dense deposits (P < 0.001). There were no significant differences in clinical features between the groups. Two children with SMGN underwent a repeat biopsy 3 yr after the first biopsy, and both patients again showed SMGN. At the final observation (mean observation time 7.5 yr in SMGN and 12.4 yr in GMGN), all children of both groups had a good outcome. In conclusion, these findings as a whole suggest that SMGN may be another glomerular disease entity with child predominance that is distinctive from GMGN.

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“…This network linked investigators in the United States and Europe and conducted remarkably informative studies of the value of renal biopsy as a tool and the correlation of biopsy findings with treatment and prognosis (18,29,30). The use of light microscopy, immunofluorescence, and electron microscopy techniques by the ISKDC and other groups permitted the clinicopathologic identification of several important renal disorders including membranoproliferative glomerulonephritis (31,32), IgA nephropathy (Berger disease) (33), and membranous nephropathy (34).…”

Section: Emergence Of Pediatric Nephrology As a Distinct Disciplimentioning

confidence: 99%

The Development of Pediatric Nephrology

Chesney

2002

Pediatr Res

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The following is the first article in this series. It Pediatric nephrology, as a discipline, arose from descriptive studies of childhood glomerulonephritis in Europe and the field of pediatric metabolism in the United States. While pediatric scientists before 1950 were concerned with fluid and electrolyte metabolism, regulation of intracellular and extracellular fluid, acid-base homeostasis, and parenteral fluid therapy, the defined field of nephrology developed after the Second World War around six major advances: ACTH and glucocorticoid therapy for nephrotic syndrome; renal biopsy to diagnose glomerular disease; the role of immunologic factors in glomerular injury; the use of dialysis as renal replacement therapy; renal transplantation as the optimal form of therapy in children with end stage renal failure; and recognition of renal disease in the etiology of 80% of cases of childhood hypertension. These discoveries led to focused research, the definition of specific training in nephrology, establishment of an American, European, and an International Society of Pediatric Nephrology, as well as an American SubBoard of Pediatric Nephrology, and the inception of a journal, Pediatric Nephrology, now in its 15th year. Major research themes have included developmental nephrology, transplantation immunology, and concerns about growth in children with renal disease. Many clinical entities have been described in detail, some of which are almost confined to children. The scientific basis of pediatric nephrology, ongoing patient care needs, and its technical aspects -renal biopsy, dialysis and transplantationassure its continuing future as a major pediatric discipline on all continents. (Pediatr Res 52: 770-778, 2002) I. THE ORIGINS OF INTEREST IN CHILDHOOD RENAL DISEASES: 1820 -1950The development of the discipline of pediatric nephrology arose from clinical research conducted in the 130-year period from 1820 to 1950. It was during this period that pediatric scientists became interested in the definition of glomerular disorders and in fluid and electrolyte metabolism, the maintenance of normal volume and tonicity and acid-base status, as well as the pathophysiology of such disorders as rickets and diarrhea (1-5) ( Table 1).Pediatric kidney disease was initially considered from a descriptive rather than quantitative perspective. Early treatises on kidney diseases in children were remarkably accurate in terms of their clinical descriptions of various renal disorders, particularly glomerular conditions. In the 11th edition of Eduard Henoch's classic text Kinderkrankheiten (6), he describes

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Extramembranous glomerulonephritis inchildren: Report of 50 cases

Cited by 111 publications

References 15 publications

Infantile Immunoglobulin A Nephropathy Showing Features of Membranoproliferative Glomerulonephritis

Infantile Immunoglobulin A Nephropathy Showing Features of Membranoproliferative Glomerulonephritis

Segmental Membranous Glomerulonephritis in Children

The Development of Pediatric Nephrology

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