Extranasopharyngeal angiofibroma of the nasal septum - uncommon presentation of a rare disease

Correia, Felipe Gustavo; Simões, Juliana Caminha; Neto, José Arruda Mendes; Alves, Maria Teresa de Seixas; Gregório, Luiz Carlos; Kosugi, Eduardo Macoto

doi:10.5935/1808-8694.20130118

Cited by 11 publications

(11 citation statements)

References 4 publications

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“…Angiofibromas of the nasal septum is extremely [2]. Site of origin of nasal septal angiofibromas (NSAs) previously described includes the anterior 1/3 of septum (cartilagenous septum), bony cartilaginous junction, as well as perpendicular plate of ethmoid [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]. This varied site of origin within the nasal septum suggests the possibility of the tumour arising from ectopic tissue due to migration error during development of the nasal septum [2].…”

Section: Discussionmentioning

confidence: 99%

Nasal Septal Angiofibroma in a Post-Menopausal Woman: A Rare Entity

Ewe

Dayana

Fadzilah

et al. 2015

JCDR

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A 67-year-old lady presented to the Otorhinolaryngology clinic with complaints of right nasal obstruction for the past 6 months. She had no symptoms of persistent rhinorrhoea, recurrent epistaxis, anosmia, facial pain, facial numbness, headache, epiphora and diplopia. She had neither accompanying ear or throat symptoms nor preceding history of trauma or infection. She was a non-smoker, with no known occupational exposure risk factors. Endoscopic examination revealed a firm, smooth surface lobulated red mass arising from the right anterosuperior septum impinging on the inferior turbinate. The left nasal cavity looked normal. The nasopharynx, oropharynx and larynx were otherwise normal. There were no palpable cervical lymph nodes. Our initial working diagnosis was pyogenic granuloma, septal turbinate or nasal lymphoma. We proceeded with an office biopsy of the mass to rule out malignancy.Biopsy of the mass resulted in minimal bleeding and haemostasis was secured. Proliferation of thin-walled vessels in dense fibrous stroma was seen in the biopsy specimen, and histologically the mass was diagnosed as an angiofibroma [Table/ Fig-1]. A computerized tomography (CT) scan with contrast revealed a localised welldefined small mildly enhancing soft tissue lesion measuring 0.8cm by 0.4cm by 0.8cm, confined to the right anterosuperior septum with mild deviation of the nasal septum to the right. The soft tissue ABSTRACTJuvenile angiofibromas (JAs) are well-characterised in literature, arising typically in the posterolateral wall of the nasal cavity of young males. Numerous theories have been proposed to explain the occurrence of this unique and rare tumour. Angiofibromas originating in other sites within the head and neck have been described but this is exceedingly rare, constituting less than 2% of all diagnosed cases. Extranasopharyngeal angiofibroma is a rare lesion, and more importantly, controversial. It is not known whether it is actually a relative of the well-known JA that is seen exclusively in adolescent males. We present the case of a post-menopausal woman with unilateral nasal obstruction who was unexpectedly diagnosed as nasal septal angiofibroma.

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Section: Discussionmentioning

confidence: 99%

Nasal Septal Angiofibroma in a Post-Menopausal Woman: A Rare Entity

Ewe

Dayana

Fadzilah

et al. 2015

JCDR

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“…In the recent literature, only 75 cases have been reported including their case series ( 4 ). There were five more cases of extra-nasopharyngeal angiofibromas reported in the literature since then ( 5 - 9 ). Only one parapharyngeal angiofibroma was reported in a 25-year-old male in the English literature ( 10 ).…”

Section: Discussionmentioning

confidence: 99%

Parapharyngeal Angiofibroma: A Case Report

Lee

2015

Iran J Radiol

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“…Angiofibromas outside the NA, extra-nasopharyngeal angiofibromas (ENAF), most frequently involve the maxilla2 but can also be found in the ethmoid, nasal cavities or nasal septum3, although these localizations are uncommon. Characteristics of ENAF tend to be quite different from an angiofibroma of the NA, including patient gender45, patient age2, prevalence, affected site, pathogenesis, and clinical and epidemiological features67, and some authors classify ENAF as a different disease89. Although management of ENAF is not fully codified, imaging, endoscopy, and clinical features are extremely helpful in diagnosis, and embolization has been used in selected cases10.…”

Section: Introductionmentioning

confidence: 99%

“…Various therapeutic approaches have been proposed, including radiotherapy (RT)8, endoscopic surgery, and preoperative embolization. The majority of arteriovenous malformations, including ENAF, are treated with embolization of the hypervascular lesion during arteriography combined with surgical treatment415.…”

Section: Introductionmentioning

confidence: 99%

Nasal septum angiofibroma: a rare condition with an unusual onset

Spinosi

D’Amico

Mezzedimi

et al. 2019

J Korean Assoc Oral Maxillofac Surg

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The characteristics of extra-nasopharyngeal angiofibromas tend to be different from angiofibromas of the nasopharynx according to patient gender, patient age, prevalence, affected site, pathogenesis, and clinical and epidemiological features. We report a case of an extra-nasopharyngeal angiofibroma in a 28-year-old man referred to the ENT Clinic for right-sided epistaxis, airflow impairment and nasal swelling. The right nostril was completely occluded works by a reddish-yellow mass that bled easily. The computed tomography scan revealed an “inhomogeneous solid lesion in the nasal fossa”. With the patient under general anesthesia, the formation in the anterior portion of the right side of the nasal septum was removed up to its vascular base. Although electrical cauterization efficiently controlled the bleeding, we abraded the sub-perichondral area to prevent further bleeding as well as recurrence. The histological exam report confirmed the diagnosis of angiofibroma. As in our case, epistaxis is commonly the presenting sign of angiofibroma. Yet its onset was peculiar, given that the bleeding started with a low impact trauma. The nasal swelling was also a relevant feature as well as the breathing impairment. Although uncommon, nasal septal angiofibromas should considered in patients with epistaxis.

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Extranasopharyngeal angiofibroma of the nasal septum - uncommon presentation of a rare disease

Cited by 11 publications

References 4 publications

Nasal Septal Angiofibroma in a Post-Menopausal Woman: A Rare Entity

Nasal Septal Angiofibroma in a Post-Menopausal Woman: A Rare Entity

Parapharyngeal Angiofibroma: A Case Report

Nasal septum angiofibroma: a rare condition with an unusual onset

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