Extranodal lymphoma arising within the maxillary alveolus: a systematic review

MacDonald, David; Lim, Sean H.

doi:10.1007/s11282-017-0309-5

Cited by 10 publications

(9 citation statements)

References 76 publications

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“…2 Malignancies arising within the alveolus may initially present as dental infections. 3 Although the clinical examination is of paramount importance, it can only penetrate as far as the eye can see, the fingers can palpate, and dental instruments can probe, or to the extent that percussion and vitality testing can assess. To examine deeper, particularly into the bones of the jaws, requires radiography.…”

Section: Introductionmentioning

confidence: 99%

Incidental findings in a consecutive series of digital panoramic radiographs

MacDonald

2020

Imaging Sci Dent

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Purpose: The aim of this study was to determine the prevalence of incidental findings (IFs) on digital dental panoramic radiographs (DPRs) of asymptomatic patients attending a general dental practice. Materials and Methods: This was a retrospective study of 6,252 consecutive digital (photostimulatable phosphor) DPRs of patients who visited a Canadian general dental practice for a complete new patient examination. The IFs were grouped into dental-related anomalies, radiopacities and radiopacities in the jaws, changes in the shape of the condyles, and other findings in the jaws, such as tonsilloliths and mucosal antral pseudocysts. Their prevalence was determined. Results: Thirty-two percent of the DPRs showed at least 1 IF. The highest prevalence was found for dental-related anomalies (29% of all DPRs), of which impacted teeth were the most prevalent finding (24% of all DPRs), followed by idiopathic osteosclerosis (6% of all DPRs). A lower prevalence was noted for tonsilloliths (3%), and the prevalence of root tips, mucosal antral pseudocysts, and anomalies in condylar shape was approximately 1% each. Conclusion: The observed prevalence of 32.1% for IFs of any type underscores the need for a dental practitioner to review the entire DPR when a patient presents for an initial dental examination (or checkup) or for dental hygiene. Only a single IF (a central giant cell granuloma) provoked alarm, as it was initially considered malignant. Similarly, impacted teeth and suspected cysts need careful evaluation upon discovery to determine how they may be optimally managed.

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Section: Introductionmentioning

confidence: 99%

Incidental findings in a consecutive series of digital panoramic radiographs

MacDonald

2020

Imaging Sci Dent

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“…The most frequent symptoms of NHL arising within the maxillary sinus are pain, swelling, nasal obstruction, paresthesia and numbness [25,30]. The patient had few or no typical complaints, suggesting the presence of periapical inflammation and maxillary sinusitis localized to the left upper premolar region; therefore, a definitive diagnosis was hardly determinable.…”

Section: Discussionmentioning

confidence: 96%

“…The presence of extra nodal lymphomas of the jawbones is exceptional [10,30]. Since very little data are available on the pathogenesis and clinical behaviour of HGBL, NOS lymphomas are referred to as "grey-zone" lymphomas, and there is no consensus on their standard therapy [23].…”

Section: Discussionmentioning

confidence: 99%

High-Grade B-Cell Lymphoma Not Otherwise Specified (HGBL, NOS) in the Maxillary Sinus Mimicking Periapical Inflammation: Case Report and Review of the Literature

et al. 2021

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High-grade B-cell lymphoma not otherwise specified is listed as a new group in the WHO 2017 statement as a subtype of aggressive, mature B-cell lymphomas with a poor prognosis. To our knowledge, no description of this genetic type of maxillary lymphoma has appeared in the literature until now; thus, our case provides valuable data on its symptoms, clinical behavior, response to treatment and survival rate. The present report describes the early diagnosis and treatment of an extremely rare histological subtype of B-cell lymphoma, a case of high-grade B-cell lymphoma not otherwise specified, localized in the maxillary sinus and mimicking signs and symptoms of periapical inflammation. After chemotherapy, the presented patient showed complete remission without relapse and systemic spread. As far as we know, this is the first reported case of this rare type of lymphoma associated with the maxillary sinus. Considering that high-grade B-cell lymphomas are aggressive tumors with rapid growth and poor prognosis, which are often misdiagnosed in the early stages as inflammatory disease, it is relevant to highlight the importance of a detailed evaluation of clinical signs and radiological findings during diagnosis, especially if they contradict each other.

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“…3,4,15 Most lymphomas involving the jaws are frequently associated with teeth, either causing tooth displacement, mobility or pain. 9,16 This presentation can lead to inappropriate dental treatment due to inflammatory conditions, especially when the lesion was located at the tooth root apex. Consequently, dental extractions, endodontic treatments, periodontal therapy and the use of different medications were some of the initial treatment options in these patients, with a resultant negative impact on patients.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, any untimely delay in the recognition and diagnosis of these neoplasms may negatively impact the therapeutic management of affected patients. 9,10 Currently, the literature is scarce on describing the most common subtypes and radiological features of haematolymphoid malignancies affecting the OMF region. Therefore, this study aimed to analyse the clinicoradiological features of malignant haematolymphoid neoplasms affecting the jaws by assessing individual case reports available in the literature following a systematic review approach.…”

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confidence: 99%

Radiological aspects of lymphomas and leukaemias affecting the jaws: A systematic review

Gomes

Lima

Morais-Perdigão

et al. 2023

J Oral Pathology Medicine

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Background: This systematic review aimed to investigate the radiological features of lymphomas and leukaemias affecting the jaws.Methods: A systematic literature review was conducted using the electronic databases of PubMed, Web of Science and Scopus. Articles that contained sufficient radiographic examinations (periapical, panoramic or computed tomography images) for individual cases were included. Additionally, either immunohistochemical or molecular confirmation was required prior to inclusion. Three authors evaluated and described the image quality and radiological features.Results: From an initial 1079 articles screened, 129 cases were included, containing 88 tomographic, 76 panoramic and 26 periapical examinations. The quality of the majority of images was sufficient for evaluation. Diffuse large B-cell lymphoma, Burkitt lymphoma, leukemic infiltration, plasmablastic lymphoma and extranodal Natural killer (NK)/T-cell lymphoma, nasal type were the most common subtypes. Involved teeth presented with mobility in 37.2% of the cases and a provisional diagnosis of inflammatory/infectious dental disease was considered in 49.2% of cases. Computed tomography exams were available for 76% of the cases, with most presented with an osteolytic lesion with ill-defined borders. Periosteal reactions were uncommon. Conclusion:Lymphoma/leukaemia infiltrates of the jaw bones are usually of highgrade subtypes and rarely present with periosteal reactions.

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Extranodal lymphoma arising within the maxillary alveolus: a systematic review

Cited by 10 publications

References 76 publications

Incidental findings in a consecutive series of digital panoramic radiographs

Incidental findings in a consecutive series of digital panoramic radiographs

High-Grade B-Cell Lymphoma Not Otherwise Specified (HGBL, NOS) in the Maxillary Sinus Mimicking Periapical Inflammation: Case Report and Review of the Literature

Radiological aspects of lymphomas and leukaemias affecting the jaws: A systematic review

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