Extranodal marginal zone B-cell lymphoma of Mucosa-Associated Lymphoid Tissue (MALT lymphoma) in ulcerative colitis

Abstract

Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) occurring in inflammatory bowel diseases, including ulcerative colitis (UC) and Crohn's disease, has been reported, although it is extremely rare. An 18-year-old man with a two-years history of UC underwent colon endoscopy, and was found to have active total UC ranging from anus to cecum. Six biopsies were obtained. The microscopic examinations showed severe infiltrations of atypical small lymphocytes. They showed hyperchromatic nuclei and increased nucleocytoplasmic ratio and scattered immunoblastic cells. Centrocyte-like atypical lymphocytes, monocytoid cells, and plasma cells were seen in some places. Vague germinal centers were present, and apparent lymphoepithelial lesions were seen. No crypt abscesses were seen, and there were few neutrophils. No apparent other findings of UC were seen. Immunohistochemically, the atypical lymphocytes were positive for vimentin, CD45, CD20, CD79α, CD138, κ-chain, λ-chain, and p53 and Ki-67 antigen (labeling index = 63%). They were also positive for CD45RO, CD3, and CD15, but these positive cells were very scant compared with CD20 and CD79α. They were negative for CD10, CD30, CD56, cytokeratin (CK) AE1/3, CK CAM5.2, CK34BE12, CK5, CK6, CK7, CK8, CK14, CK18, CK19, CK20, EMA, chromogranin, synaptophysin, NSE, S100 protein, CEA, CA19-9, p63, and HMB45. Without clinical information, the appearances are those of MALT lymphoma. However, with clinical information, making the diagnosis of MALT lymphoma was hesitated. It is only mentioned herein that atypical lymphocytic infiltrations indistinguishable from MALT lymphoma occurred in an 18-year-old male patient with a two-year history of UC.

Primary thyroid MALToma– a rare diagnosis of an unassuming thyroid nodule

“…Mucosa-associated lymphoid tissue (MALT) lymphoma is defined as extra nodal lymphoma composed of heterogeneous small B cells arising from marginal zone of MALT [1]. It most frequently occurs in the gastrointestinal tract mucosa (50%), head and neck (15%), lung (14%), skin (11%), thyroid (4%), and breast (4%) [1–3].…”

“…It most frequently occurs in the gastrointestinal tract mucosa (50%), head and neck (15%), lung (14%), skin (11%), thyroid (4%), and breast (4%) [1–3]. Primary thyroid lymphoma (PTL) is a rare form of malignancy, constituting about 2–8% of all thyroid malignancies and 1–2% of all extra nodal lymphomas [3,4].…”

Primary classical Hodgkin lymphoma (mixed cellularity) of stomach presenting multiple polyps

“…[1][2][3][4] Most of gastrointestinal lymphomas are non-Hodgkin lymphomas (NHL), and of those the most prevalent are MALT lymphoma and diffuse large B-cell lymphoma (DLBCL). [1][2][3][4] Hodgkin lymphomas are classified into the following two major categories: nodular lymphocyte predominant Hodgkin lymphoma and classical Hodgkin lymphoma (CHL).…”

“…[1][2][3][4] Most of gastrointestinal lymphomas are non-Hodgkin lymphomas (NHL), and of those the most prevalent are MALT lymphoma and diffuse large B-cell lymphoma (DLBCL). [1][2][3][4] Hodgkin lymphomas are classified into the following two major categories: nodular lymphocyte predominant Hodgkin lymphoma and classical Hodgkin lymphoma (CHL). Hodgkin lymphoma is characterized by the presence of typical Hodgkin cells (HC) and/or Reed-Sternberg giant cells (RSC) accompanied by various fibroinflammatory non-neoplastic reactions, which sub-categorize the CHL into the following four subtypes: lymphocytic predominance, mixed cellularity, lymphocytic deletion, and nodular sclerosis.…”

Primary follicular lymphoma of the prostate

“…[1][2][3] A group of B-cell lymphomas composed of small lymphocytes are characterized by relatively indolent clinical course. [4][5][6][7] These biologically indolent B-cell lymphomas includes the following five categories: small lymphocytic lymphoma/CLL (SLL/CLL), lympho-plasmacytic lymphoma (LPL), marginal zone B-cell lymphoma (MZBL) (aka MALT lymphoma), follicular lymphoma (FL), and mantle cell lymphoma (MCL). FL is thought to originate from germinal center B-cells, and is characterized by follicular or nodular structures, partially or totally, with a bcl-2 aberrant immuno-expression.…”