Extranodal nasal type NK/T-cell Lymphoma: Elucidating clinical prognostic factors for risk-based stratification of therapy

Lee, Jeeyun; Park, Yeon Hee; Kim, Won Seog; Lee, Seung-Sook; Ryoo, Baek‐Yeol; Yang, Sung Hyun; Park, Keon Woo; Kang, Jung Hoon; Park, Joon Oh; Lee, Se‐Hoon; Kım, Kihyun; Jung, Chul Won; Park, Young Suk; Im, Young‐Hyuck; Kang, Won Ki; Lee, Mark H.; Ko, Young Hyeh; Ahn, Yong Chan; Park, Keunchil

doi:10.1016/j.ejca.2005.03.010

Cited by 148 publications

(130 citation statements)

References 21 publications

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“…20,40 Among pathology parameters, an adverse prognosis was correlated with a high Ki-67 labeling index and EBV DNA load but not with cellular morphology or the expression of CD56. 30,31,41 Pongpruttipan et al 8 suggested that patients with a T-cell ENKTL in the upper airway tended to have better survival although this did not reach statistical significance. In our study, the patients with a localized T-cell ENKTL tended to have a better prognosis than those with an NK-cell ENKTL, but the impact of cell lineage on prognosis was not statistically significant.…”

Section: Modern Pathology (2016) 29 430-443mentioning

confidence: 99%

“…A significantly better prognosis was reported for patients with an nasal ENKTL, compared with other sites. [29][30][31] The latter groups had an advanced stage at diagnosis, higher LDH levels, higher IPI scores, worse performance, and a significantly worse response to anthracycline-based chemotherapy. 32 A novel regimen containing L-asparaginase (SMILE) had a better effect than anthracycline-based chemotherapy.…”

Section: Modern Pathology (2016) 29 430-443mentioning

confidence: 99%

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Nasal-type NK/T-cell lymphomas are more frequently T rather than NK lineage based on T-cell receptor gene, RNA, and protein studies: lineage does not predict clinical behavior

et al. 2016

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Extranodal natural killer (NK)/T-cell lymphoma (ENKTL), nasal type, comprises NK or cytotoxic T cells. We evaluated the clinical impact of cell type and the usefulness of T-cell receptor (TCR) gene transcripts in distinguishing cell lineage. One hundred and eight cases of ENKTL were analyzed for TCR gene rearrangements using the BIOMED-2 protocol and for TCR gene expression using immunohistochemistry for TCR-βF1 and TCR-cγM1, and RNA in situ hybridization for TCR gene transcripts. Prognostic factors were analyzed. Among the 108 cases, 44 were monoclonal for a TCR rearrangement (40%) while 64 (60%) were undefinable. The monoclonal cases expressed TCR-βF1 in 14 out of 40 cases (35%) and TCR-cγM1 in 1 out of 44 cases (2%). The 64 undetermined cases expressed TCR-βF1 in 15 cases (23%) and TCR-cγM1 in 1 (2%). Thirteen of 40 TCR-β constant gene transcript-positive cases (33%) expressed TCR-βF1 and one of nine TCR-γ constant gene transcript-positive cases (11%) expressed TCR-cγM1. TCR gene transcripts were not useful in the distinction of cell lineages. TCR gene transcripts were positive in ENKTLs as well as in normal B cells and aggressive NK-cell leukemia. Based on gene rearrangements and immunohistochemistry for TCR, there were 60 T-cell type cases (56%), 32 NK-cell type cases (30%), and 16 cases with an undetermined cell type (14%). TCR protein was expressed in 30/60 T-ENKTLs (50%) in a variable fraction of tumor cells. There were no significant differences in clinical findings or overall patient survival between T-or NK-cell types of ENKTL, although those with a T-cell type tended to show a better prognosis for those with localized nasal lymphomas. Univariate and multivariate analysis showed that a non-nasal ENKTL, age 460 years, high level of lactate dehydrogenase, bone marrow involvement, and the absence of radiotherapy were independent prognostic factors.

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Section: Modern Pathology (2016) 29 430-443mentioning

confidence: 99%

Section: Modern Pathology (2016) 29 430-443mentioning

confidence: 99%

Nasal-type NK/T-cell lymphomas are more frequently T rather than NK lineage based on T-cell receptor gene, RNA, and protein studies: lineage does not predict clinical behavior

et al. 2016

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“…6 Furthermore, it has been suggested by several groups including ours that patients with extra-upper aerodigestive tract (EUNKTL) had poorer prognosis to conventional anthracycline-based chemotherapy. 7,8 Few reports have demonstrated promising results with highdose chemotherapy and autologous stem cell transplantation (HDC/ASCT) in NK/T-cell lymphoma patients as a salvage treatment. [9][10][11][12][13][14] It is inconclusive, however, from these studies, to consider HDC/ASCT as a standard treatment due to small cohort of patients.…”

Section: Introductionmentioning

confidence: 99%

High-dose chemotherapy with autologous stem cell transplantation in extranodal NK/T-cell lymphoma: a retrospective comparison with non-transplantation cases

Kim

Bang

Lee

et al. 2006

Bone Marrow Transplant

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“…El tratamiento en estadios precoces es la radioterapia mientras que en fases avanzadas se asocia quimioterapia. Se trata de un linfoma de alto grado, con sobrevida de 3 meses a 2 años y mortalidad hasta en el 82% de los casos 8 .…”

Section: Discussionunclassified

Linfoma T/NK extraganglionar tipo nasal: Caso clínico

et al. 2017

Rev. Otorrinolaringol. Cir. Cabeza Cuello

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Extranodal nasal type NK/T-cell Lymphoma: Elucidating clinical prognostic factors for risk-based stratification of therapy

Cited by 148 publications

References 21 publications

Nasal-type NK/T-cell lymphomas are more frequently T rather than NK lineage based on T-cell receptor gene, RNA, and protein studies: lineage does not predict clinical behavior

Nasal-type NK/T-cell lymphomas are more frequently T rather than NK lineage based on T-cell receptor gene, RNA, and protein studies: lineage does not predict clinical behavior

High-dose chemotherapy with autologous stem cell transplantation in extranodal NK/T-cell lymphoma: a retrospective comparison with non-transplantation cases

Linfoma T/NK extraganglionar tipo nasal: Caso clínico

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