Extranodal NK / T-cell lymphoma with cutaneous involvement: ‘nasal’ vs. ‘nasal-type’ subgroups- a retrospective study of 18 patients

Yl, Choi; Jh, Park; Jh, Namkung; Jh, Lee; Yuan, Jian‐Min; Es, Lee; Dy, Lee; Kt, Jang; Yh, Ko

doi:10.1111/j.1365-2133.2008.08922.x

Cited by 80 publications

(72 citation statements)

References 18 publications

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“…4,18 However, according to other investigators, 1,8,9,19 in our cases the exclusively cutaneous presentation observed in 4 cases was not associated with a better prognosis; all patients died despite the therapy with a 12-month survival rate of 40%. Case 5 had an early lymph node involvement with a very short survival rate.…”

Section: Follow-upsupporting

confidence: 47%

“…3 PC-ENK/T-NT lymphoma is rarer; from a review of the literature, only approximately 57 cases are reported and less than 20 cases were in Western countries. [4][5][6][7][8][9][10] However, its real frequency is difficult to establish correctly, because all required data are not always available.…”

Section: Enk/t-nt Lymphoma With Initial Presentation In the Skin Is Kmentioning

confidence: 99%

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Cutaneous extranodal NK/T-cell lymphoma: a clinicopathologic study of 5 patients with array-based comparative genomic hybridization

Berti

Recalcati

Girgenti

et al. 2010

Blood

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Section: Follow-upsupporting

confidence: 47%

Section: Enk/t-nt Lymphoma With Initial Presentation In the Skin Is Kmentioning

confidence: 99%

Cutaneous extranodal NK/T-cell lymphoma: a clinicopathologic study of 5 patients with array-based comparative genomic hybridization

Berti

Recalcati

Girgenti

et al. 2010

Blood

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“…This is the lower incidence of extranasal disease in our hospital. Referral bias is important since nasal and cutaneous disease may be referred initially to orolaryngology or dermatology center [6][7][8][9]. Because of the majority of patients with stage I/II of nasal NK/T lymphoma, RT alone is an important modality.…”

Section: Discussionmentioning

confidence: 99%

The clinical study of extranodal natural killer cell lymphoma, nasal type

et al. 2010

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To analyze the clinical characteristics, treatment of extranodal NK/T-cell lymphoma, nasal type, the term "nasal type" describes in the nasal cavity and also in the extranasal sites. There were 82 patients with nasal NK/T lymphoma (group 1) and 11 patients with extranasal NK/T lymphoma (group 2). In group 1, 4 patients gave up treatment. Five patients received radiotherapy (RT) alone. Fifty-seven patients were treated with combination of chemotherapy and RT. Sixteen patients received chemotherapy alone. Most patients (82.9%) had stage I/II disease and a high frequency (about one-third) of B symptoms. The CR rate was 53.8%. The OS rate was 62.8% (49/78 cases). Three patients died in relation to L-asparaginase. Three patients with late relapses occurred at 10 and 17 years from CR, respectively. In group 2, except that one patient received chemoradiotherapy, 10 patients received chemotherapy. Seven patients died. The OS rate was 36.4%. Our study suggested that nasal and extranasal variants of extranodal NK/T lymphoma, nasal type represented different clinical behavior and prognosis. For comparison, extranasal NK/T lymphoma is more aggressive and higher mortality than nasal NK/T lymphoma.

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“…Multidrug chemotherapy has not been shown to improve outcomes due to the very aggressive nature of this disease. Proposed treatment options include cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) or etoposide, prednisone, vincristine, cyclophosphamide and doxorubicin (EPOCH) [1,4,7] . Unlike nasal NK/T-cell lymphoma, mortality rates have not been well defined for non-nasal aggressive NK/T-cell leukemia/lymphoma but remain exceedingly high, especially within the first 6 weeks to two months, often due to multisystem organ failure [1-3, 5, 6, 9] .…”

Section: Discussionmentioning

confidence: 99%

Fatal pulseless electrical activity in an African American man with natural killer/T-cell leukemia/lymphoma and myocardial involvement

Topoll

Wilfong

Pildain

et al. 2015

CRIM

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A 50-year-old previously healthy man presented with acute shortness of breath, fever, and back pain. Physical examination was normal. He rapidly developed hypoxemic respiratory failure requiring mechanical ventilation and pancytopenia. An extensive infectious work up was negative. After a gallium scan showed increased uptake in the lungs, he underwent bone marrow biopsy and open lung biopsy. The lung and bone marrow biopsies revealed Natural Killer/T-cell lymphoma/leukemia. Immediately after the open lung biopsy, the patient developed cardiac arrest with pulseless electrical activity from which he could not be resuscitated. At autopsy, he had extensive NK/T-cell lymphoma involving multiple organs, including the heart, lung, bone marrow, adrenal glands, and lymph nodes. The heart was the most prominently affected organ with involvement of the cardiac conduction system.

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Extranodal NK / T-cell lymphoma with cutaneous involvement: ‘nasal’ vs. ‘nasal-type’ subgroups- a retrospective study of 18 patients

Cited by 80 publications

References 18 publications

Cutaneous extranodal NK/T-cell lymphoma: a clinicopathologic study of 5 patients with array-based comparative genomic hybridization

Cutaneous extranodal NK/T-cell lymphoma: a clinicopathologic study of 5 patients with array-based comparative genomic hybridization

The clinical study of extranodal natural killer cell lymphoma, nasal type

Fatal pulseless electrical activity in an African American man with natural killer/T-cell leukemia/lymphoma and myocardial involvement

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