Extranodal NK/T-Cell Lymphomas: The Role of Natural Killer Cells and EBV in Lymphomagenesis

Saleem, Atif; Natkunam, Yasodha

doi:10.3390/ijms21041501

Cited by 18 publications

(17 citation statements)

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“…Dentro de las células, el VEB persiste en forma episomal, no integrado al genoma del hospedero. El VEB tiene tres patrones de latencia; el patron tipo II es el más frecuente asociado a linfoma extranodal T/NK y está caracterizado por la expresion de las proteínas virales EBNA1 y LMP1 13 .…”

Section: Discussionunclassified

Linfoma extranodal de células T/NK, tipo nasal. Reporte de caso

Pérez-García¹,

Arellano-Mendoza²,

Fuentes-Nava³

et al. 2022

MCUT

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El linfoma de células T/NK es poco frecuente. Las lesiones cutáneas presentan una gran variabilidad clínica al momento de su presentación, desde neoformaciones tipo placa hasta nódulos o úlceras. Presentamos el caso de una mujer de 46 años que presentó perforación de paladar y nódulos y úlceras no dolorosas en el tronco y las extremidades inferiores. Se realizó abordaje diagnóstico, a descartar micosis profunda, y se realizó biopsia de piel con inmunhistoquímica que confirmó un linfoma de células T/NK extranodal de tipo nasal. Se inició tratamiento por parte de hematología con quimioterapia, pero la sobrevida fue de 4 semanas.

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Section: Discussionunclassified

Linfoma extranodal de células T/NK, tipo nasal. Reporte de caso

Pérez-García¹,

Arellano-Mendoza²,

Fuentes-Nava³

et al. 2022

MCUT

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“…Both SNK-6 and NK-92 cells are originated from ENKTCL patients, but significant differences exist concerning the expression level of latent membrane protein-1 (LMP-1), which is strongly expressed in SNK-6 cells and weakly expressed in NK-92 cells. LMP-1, as the oncogenic gene of EBV, can be detected in nearly all patients of ENKTCL 29 . Our study demonstrated that the RNA level of BCYRN1 was significantly higher in SNK-6 cells than in NK-92 cells, indicating a potential causal relationship between BCYRN1 expression and LMP-1, which warrants further investigation.…”

Section: Discussionmentioning

confidence: 99%

LncRNA BCYRN1-induced autophagy enhances asparaginase resistance in extranodal NK/T-cell lymphoma

Wang¹,

Yang²,

Wang³

et al. 2021

Theranostics

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Background: Asparaginase (ASP) is the cornerstone drug in the treatment of extranodal NK/T-cell lymphoma (ENKTCL), and the mechanisms of resistance to ASP remain largely unknown. Long non-coding RNAs play important roles in chemotherapy resistance in various cancers. However, the expression of BCYRN1 and its role in ENKTCL still remain unidentified. Methods: Lentivirus-mediated BCYRN1 overexpression and knockdown were performed in SNK-6 cells. Cell autophagy was analyzed by adenovirus expressing GFP-LC3B fusion protein. RNA pull-down and RNA Binding Protein Immunoprecipitation Assay were performed to investigate the relationship between BCYRN1 and p53. Western blot analysis was performed to assess the effect of BCYRN1 on different autophagy pathways. Finally, in vivo xenograft tumor model was constructed to analyze the effect of BCYRN1 on tumor growth and ASP resistance. Results: BCYRN1 was overexpressed in ENKTCL than normal NK cells, and patients with higher expression had significantly inferior progression-free survival (PFS). The IC50 value of ASP was significantly increased in BCYRN1-overexpressed SNK-6 cells and BCYRN1 overexpression could resist the inhibitory effect of ASP on proliferation. ASP could induce concurrent apoptosis and autophagy in ENKTCL, and the latter process was enhanced by overexpression of BCYRN1, mainly through affecting both PI3K/AKT/mTOR and p53/mTOR pathways. BCYRN1 could induce the degradation of p53 via ubiquitination, thus resulting in enhancement of autophagy and ASP resistance, which could be reversed by drug-induced autophagy inhibition. The effect of BCYRN1 on tumor growth and autophagy were confirmed in vivo xenograft model. Conclusions: It was found that BCYRN1 was a valuable prognostic biomarker in ENKTCL. BCYRN1 could promote resistance to ASP by inducing autophagy, which could be reversed by inhibition of autophagy. Our findings highlight the feasibility of combining autophagy inhibition and ASP in the treatment of ENKTCL.

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“…However, there was no significant difference in OS rate between patients receiving HSCT with LAHS and lymphoma ( p = 0.200), suggesting that LAHS patients in HLH remission status can achieve the outcome of patients with lymphoma, so the treatment of LAHS patients should focus on HLH in the early stage and HLH remission lymphoma treatment afterward. The prognosis of NK-derived lymphoid proliferative diseases (LPD) with or without EBV differs significantly, the former exhibiting a more aggressive course ( 31 ). Since most quantitative polymerase chain reaction (PCR) assays target encapsulated viral particles and circulating EBV DNA, viremia may reflect only tumor-shed DNA and not viral replication ( 32 ).…”

Section: Discussionmentioning

confidence: 99%

Clinical Features and Prognostic Risk Prediction of Non-Hodgkin Lymphoma-Associated Hemophagocytic Syndrome

Yao

Jin

et al. 2021

Front. Oncol.

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BackgroundMalignancies, especially lymphoma, are a common cause of adult secondary HLH and an independent risk factor for the prognosis of HLH patients.MethodsPatients with lymphoma alone or concurrent lymphoma-associated phagocytic syndrome (LAHS) admitted to Beijing Friendship Hospital from January 2016 to December 2020 were enrolled in this study.FindingsThere were 348 lymphoma patients, 104 concurrent with LAHS. The pathological type of lymphoma without LAHS was dominated by B-cell lymphoma, while those with LAHS were T/NK-cell lymphoma predominantly (p < 0.001). Superficial lymph node enlargement was more significant in patients with B-LAHS (p = 0.006), while patients with T/NK-LAHS had lower neutrophil counts (p = 0.005), lower fibrinogen levels (p < 0.001), higher transaminase levels, and more co-infection with EBV (p < 0.001). B-LAHS had significantly higher IL-10 levels than with T/NK-LAHS (p = 0.006), and NK/T-LAHS had significantly higher IP-10 levels than other T-LAHS (p = 0.008). Age, platelet count, IPI, history of NK/T lymphoma, and no remission of HLH were independent risk factors for prognosis in patients with non-Hodgkin lymphoma-associated phagocytic syndrome (NHL-LAHS), and a prognostic risk score model for NHL-LAHS was developed.ConclusionLAHS is a life-threatening disease with a poor prognosis. The prognostic risk score model for NHL-LAHS with a good fit and validation for the test has value for clinical application.

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Extranodal NK/T-Cell Lymphomas: The Role of Natural Killer Cells and EBV in Lymphomagenesis

Cited by 18 publications

References 50 publications

Linfoma extranodal de células T/NK, tipo nasal. Reporte de caso

Linfoma extranodal de células T/NK, tipo nasal. Reporte de caso

LncRNA BCYRN1-induced autophagy enhances asparaginase resistance in extranodal NK/T-cell lymphoma

Clinical Features and Prognostic Risk Prediction of Non-Hodgkin Lymphoma-Associated Hemophagocytic Syndrome

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