Extranodal <scp>NK</scp>/T‐cell lymphoma, nasal type: Clinical features, outcome, and prognostic factors in 101 cases

Su, Yi‐Jiun; Wang, Po‐Nan; Chang, Hong-Yeh; Shih, Lee‐Yung; Lin, Tung‐Liang; Kuo, Ming‐Chung; Chuang, Wen-Yu; Wu, Jin‐Hou; Tang, Tzung‐Chih; Hung, Yu‐Shin; Dunn, Po; Kao, Hsiao‐Wen

doi:10.1111/ejh.13126

Cited by 30 publications

(32 citation statements)

References 44 publications

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“…NKTCL appears most frequently in patients over the age of 60 years, although studies have shown that it can be found in both geriatric and pediatric patients. The mortality rate is higher than in other lymphomas and has poorer response rates to radiation and chemotherapy (3).…”

Section: Discussionmentioning

confidence: 95%

NK/T‑cell non‑Hodgkin lymphoma: Case report and review of the literature

et al. 2020

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Natural killer (NK)/T-cell lymphomas represent a rare type of lymphoid malignancy with mostly extranodal involvement, having NK cell or (rare) T cell lineage, classified by the World Health Organization into several subtypes which can involve the head and neck region, with the most frequent one being the nasal type. This article presents the case of a 31-year-old patient who presented at the Emergency Unit of Saint Andrew Emergency Clinical Hospital of Galati suffering from mycosis fungoides-like cutaneous lesions, associated with partial left eyelid ptosis of unknown etiology, as well as a poor health status with fever and respiratory failure. The final diagnosis was NK/T-cell non-Hodgkin lymphoma, possibly nasal type with medium sized T cells. The complexity of the rare diagnosis, associated with the unusual rapid patient evolution towards exitus 3 months after diagnosis, the intra-orbital metastatic involvement and the absence of a standardized treatment are case peculiarities, some of which are consistent with current literature data.

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Section: Discussionmentioning

confidence: 95%

NK/T‑cell non‑Hodgkin lymphoma: Case report and review of the literature

et al. 2020

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“…The prognosis of primary NK/T-cell lymphoma of the testis remains very poor and, even more so, in the nasal type. In a series of 101 patients of ENKTCL in Taiwan, published by Su et al ,5 5 years overall survival was 55% and 72% in patients with stages I–II. EBV DNA is a surrogate biomarker of the lymphoma load and should be followed during the course of the disease 10…”

Section: Discussionmentioning

confidence: 98%

“…NK/T-cell lymphoma typically presents with involvement of the nasal cavity, nasopharynx, oropharynx and paranasal sinus as primary sites in more than 80% of the cases, referred to as ‘nasal-type’. Even if most of the patients have the diagnosis at stage I/II, there is a high relapse rate after radiochemotherapy of more than 30% 5…”

Section: Introductionmentioning

confidence: 99%

Sinonasal relapses of a primary isolated extranodal NK/T-cell lymphoma of the testis

Hallak¹,

Cairoli

Bouayed

et al. 2019

BMJ Case Rep

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WHO first recognised extranodal NK/T-cell lymphoma (ENKTCL) in 2001, thanks to technical advances in anatomopathology and immunohistochemistry. It is divided into nasal and extranasal subgroups depending on the primary site. Primary isolated NK/T-cell lymphoma of the testis is rare. Typical recurrence sites of primary testicular NK/T-cell lymphoma are the gastrointestinal tract, lymph nodes, skin, spleen and central nervous system. Nasal relapses of a primary NK/T-cell lymphoma of the testis are very rare and according to our knowledge, no other case has been reported yet in the literature. The authors report the case of a 35-year-old Caucasian man relapsing twice in the nasal cavity 1 year after initial diagnosis and treatment of a primary isolated, stage IE, ENKTCL of the testis. We report the clinical and radiological presentation of the nasal relapses and the different modalities of treatment that were applied. Sinonasal relapses of an isolated primary NK/T-cell lymphoma of the testis are very rare. ENKTCL is a very aggressive entity, even at an early stage, therefore, requiring a multimodal treatment approach including chemotherapy and radiotherapy. New strategies to treat this disease are needed.

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“…Extranodal natural killer/T-cell lymphoma (ENKTL) is an aggressive and unusual subtype of non-Hodgkin lymphoma (NHL) that is associated with the Epstein-Barr virus (EBV) (1,2). The incidence of this disease is relatively high in East Asia and South America, while it is low in the Western world.…”

Section: Introductionmentioning

confidence: 99%

Proteomic Analysis of Cerebrospinal Fluid From Patients With Extranodal NK-/T-Cell Lymphoma of Nasal-Type With Ethmoidal Sinus Metastasis

Zeng

Zhao

et al. 2020

Front. Oncol.

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Objective: Extranodal natural killer /T-cell lymphoma (ENKTL) is an aggressive and unusual subtype of non-Hodgkin lymphoma (NHL) that it is related with the Epstein-Barr virus (EBV). CSF is considered as an ideal source of high-concenrtation disease-related proteins. We aimed at identifying the proteomic markers changes of CSF in ENKTL patients and used such changes to diagnose ENKTL. Materials and methods: In this study, CSF samples were acquired from hospitalization patients from the Cancer Center of West China Hospital, Chengdu, China. Comparative proteomic profiling are commonly used to do label-free liquid chromatography-tandem mass spectrometry (LC-MS/MS). And in this study the same method was used to characterize the variety of proteins in ENKTL patients and none-ENKTL people. Results: In the aggregate, 421 non-excrescent and functional proteins were identified among the samples. Of these proteins, 45 proteins quantified match the involved criteria. HRG, TIMP-1, SERPINA3, FGA, FGG, TF, FGB, APP, and AGT were significantly up-regulated. Discussion: We discovered that some proteins were significantly up-regulated. Also, these proteins themselves or with others proteins may be potential markers to diagnose ENKTL. The changes of proteomics may be a potential method to precisely identify the pathogenesis of the ENKTL.

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Extranodal NK/T‐cell lymphoma, nasal type: Clinical features, outcome, and prognostic factors in 101 cases

Cited by 30 publications

References 44 publications

NK/T‑cell non‑Hodgkin lymphoma: Case report and review of the literature

NK/T‑cell non‑Hodgkin lymphoma: Case report and review of the literature

Sinonasal relapses of a primary isolated extranodal NK/T-cell lymphoma of the testis

Proteomic Analysis of Cerebrospinal Fluid From Patients With Extranodal NK-/T-Cell Lymphoma of Nasal-Type With Ethmoidal Sinus Metastasis

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